Certain drugs, including Benadryl and Cipro, appear to trigger restless legs syndrome in susceptible people. Be aware of diphenhydramine!
Some people find that tucking a bar of soap under the bottom sheet can ease restless legs syndrome, with its creepy sensations.
Restless legs syndrome can be mysterious. Most people do their best to cope with RLS. But did you know that some meds like antihistamines trigger RLS?