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Generic Name: Quinapril
Brand Name(s):
Information updated: April 1, 2000
Overview
Accupril is one of a group of drugs that includes Vasotec and Capoten.
These medications are called ACE inhibitors because they affect an
enzyme (angiotensin-converting enzyme) important in regulating blood pressure.
Accupril is often used to treat high blood pressure; it may also be
prescribed in combination with other drugs to treat some types of heart
failure.
Side Effects and Interactions
ACE inhibitors, including Accupril, can reduce
kidney function, particularly in people who already have kidney problems.
Regular monitoring is essential.
People on Accupril may experience
dizziness, fatigue, a dry persistent cough, nausea or headache.
Other
side effects reported include chest pain, palpitations, back pain, drowsiness,
constipation, hair loss, dry mouth and impotence.
In rare cases a
serious blood disorder has developed. Report any symptoms to your physician
promptly.
There are a number of compounds that can interact with
Accupril.
In general it is important to avoid potassium supplements,
including low-sodium salt substitutes.
Diuretics such as Dyazide,
Aldactazide and Moduretic which preserve potassium can also cause dangerous
elevations in potassium when taken with Accupril.
Other diuretics may
also interact with Accupril. So might the psychiatric drug lithium.
Accupril should not be taken at the same time as tetracycline, since it
can reduce absorption of the antibiotic.
Check with your doctor and
pharmacist to make sure Accupril is safe in combination with any other drugs you
take.
Special Precautions
The first few doses of Accupril you take may cause dizziness or fainting, especially for older people. Be especially careful standing up until your body adjusts.
When you start taking Accupril, be alert for a rare, but serious reaction.
Some people have experienced swelling of the face, lips, tongue and throat which can make breathing difficult if not impossible. This requires immediate emergency treatment.
African-Americans may be somewhat more susceptible to this unusual adverse effect. They are also less likely to get the full expected response to Accupril.
If you are African-American, be sure to discuss benefits and risks with your physician.
Accupril should be avoided during pregnancy, especially second and third trimesters.
Taking the Medicine
Accupril should be taken on an empty stomach, at least one hour before or two hours after a meal.
Do not stop taking Accupril suddenly, as this could lead to complications.
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Joe Graedon is a pharmacologist. Teresa Graedon holds a doctorate in medical anthropology and is a nutrition expert. Their syndicated radio show can be heard on public radio.
© 2000
Reader Comments
I have had problems with rising blood pressure since being switched to quinapril from accupril. Does anyone else have info on this?
Posted by: mary | April 23, 2008 2:52 AM