Print this page
Email a friendDrug Library
Generic Name: Propoxyphene napsylate and acetaminophen
Brand Name(s):
Information updated: April 1, 2000
Overview
Darvocet-N 100 is a popular pain reliever containing propoxyphene and
acetaminophen.
Propoxyphene, a mild synthetic analgesic, is almost as
effective as codeine. In combination with acetaminophen, it offers relief for
mild to moderate pain, such as that caused by a bad toothache or the aftermath
of minor surgery.
Side Effects and Interactions
Other side effects to be aware of include
headache, euphoria, abdominal pain, sweating and constipation.
Some
people experience shortness of breath, especially if they have asthma.
Other less common reactions include skin rash, disorientation, dry
mouth, visual problems and urinary difficulties. Report any such symptoms to
your physician promptly.
Long-term use of Darvocet-N 100 has drawbacks.
Like any narcotic, it may be habit forming if you take it regularly.
Do
not increase the dose on your own in a quest to achieve greater pain relief. But
don't play the hero by skipping doses during an acute crisis.
Pain is
more easily managed if it can be nipped in the bud instead of trying to play
catch up when it has gotten out of control.
Acetaminophen and
propoxyphene may both cause liver problems in large doses or over long periods,
so liver function should be monitored.
As kidney damage is also a
potential risk, your physician should evaluate your need for this combination
pain reliever periodically.
If you are taking any other medicines, check
with a physician or pharmacist.
Alcohol as well as certain
over-the-counter and prescription drugs can add to the sedative effect of this
analgesic.
Antihistamines, antianxiety agents, antidepressants and
sleeping pills can all cause drowsiness and might make this effect worse.
An anticonvulsant like Dilantin (phenytoin) could increase the risk of
liver trouble for patients on Darvocet-N 100.
Special Precautions
Like any narcotic, propoxyphene may make you drowsy. Do not drive or attempt any activity that requires coordination and judgment.
Older people may be more susceptible to this reaction.
Lightheadedness or dizziness could make walking dangerous. Standing up suddenly could make you feel faint.
Taking the Medicine
Some people react to Darvocet-N 100 with nausea or vomiting. Taking it with food may reduce stomach upset.
Nausea, dizziness and other common reactions may be less troublesome if you lie down for awhile.
Tags:
Bookmark/Share: 
Joe Graedon is a pharmacologist. Teresa Graedon holds a doctorate in medical anthropology and is a nutrition expert. Their syndicated radio show can be heard on public radio.
© 2000
Reader Comments
I had a severe car accident in 2004 that caused some nerve damage and disc problems in my back. The doctors wanted to put me on some really strong narcotics and I wouldn't have it. I did agree to be put on Darvocet N 100, and I have been taking that ever since for back pain. Now I am concerned about my liver. Are my worries justified?
Posted by: Debbie | March 23, 2008 9:33 PM