Drug Library
Generic Name: Lisinopril
Brand Name(s):
Information updated: April 1, 2000
Overview
Prinivil is one of the more recent entries in a class of drugs called ACE
inhibitors.
The development of this group of medications almost reads
like a medical mystery. It all started with the venom of a poisonous Brazilian
snake.
The deadly jararaca caused severe hemorrhaging. An extract from
the venom was found to affect the kidney and ultimately blood pressure
regulation. This led to the creation of enzyme blockers in Capoten, Vasotec and
Prinivil which are revolutionizing the treatment of hypertension and congestive
heart failure.
Prinivil is prescribed to lower blood pressure.
Side Effects and Interactions
People with kidney problems must be monitored
extremely carefully, as Prinivil can make kidney function worse. Even normal
people should have their physician monitor the kidneys periodically.
Prinivil can cause a number of less serious but uncomfortable side
effects. Be alert for an annoying dry cough, skin rash, headache, tiredness,
chest pain, nausea, vomiting, diarrhea, muscle cramps, low blood pressure, nasal
congestion, heart rhythm disturbances and sexual difficulties.
Report
any symptoms or suspected side effects without delay.
There are a number
of compounds that can interact with Prinivil. In general it is important to
avoid potassium supplements, including low-sodium salt substitutes.
Diuretics such as Dyazide,
Aldactazide and Moduretic which preserve potassium can also cause dangerous
elevations in potassium.
Other drugs that can interact with Prinivil
include other diuretics, the arthritis medicine Indocin and lithium.
Check with your doctor and pharmacist to make sure Prinivil is safe in
combination with any other drugs you take.
Special Precautions
The very first dose of Prinivil you take may cause dizziness, especially for older people. Be especially careful until your body adjusts.
When you first start taking Prinivil, be alert for a rare, but serious reaction. Some people have experienced swelling of the face, lips, tongue and throat which can make breathing difficult if not impossible. This requires immediate emergency treatment.
African-Americans may be somewhat more susceptible to this unusual adverse effect. They are also less likely to get the full expected response to Prinivil.
If you are African-American, be sure to discuss benefits and risks with your physician.
Taking the Medicine
Prinivil may be taken with food or on an empty stomach. It should be swallowed at the same time
every day to maintain consistent levels in the body.
Do not stop taking Prinivil suddenly,
as this could lead to complications.
Tags:
Joe Graedon is a pharmacologist. Teresa Graedon holds a doctorate in medical anthropology and is a nutrition expert. Their syndicated radio show can be heard on public radio.
© 2000





Reader Comments
I was recently prescribed this medication. I developed a dry cough, brain fog and advanced dizziness within 2 weeks. I stopped taking it immediately. I have been unable to contact my Dr. but hope to soon.
I also went to askapatient.com to read what others have experienced. Not many had positive results. That makes me reluctant to continue using this drug.
Posted by: Carol | January 1, 2008 5:57 PM
I have been on Lisinopril for 5 weeks and symptoms are not subsiding. I was started on 40mg. but was reduced to 20mg because my bp dropped so low. The first 2 weeks I had flu-like symptoms and this lessened after the dose was reduced, however still have a loss of appetite. Headaches, particularly bad upon waking, leg and muscle cramps during the night, sore throat, nasal drainage, extreme vertigo to the point of falling down, depression, constipation and bloating along with gas, frequent urination, and a general feeling of being unwell. Heart palpitations, extreme tiredness. Should I go on???
I have decided to discontinue this med, and go back to the extremely expensive Avapro, along with fish peptides, which have allowed me to reduce the avapro by half if used in conjunction. Lisinopril seems to feel like a poison, and in my opinion, has not been studied on a large enough group for an extended period of time. I am a 46 year old, otherwise extremely healthy, woman. I have not been ill in 2 years - UNTIL I went on Lisinopril! It might be interesting to note, that I am also allergic to bee stings. This also, has not been studied!
Posted by: R. Allan | March 27, 2008 2:31 PM
I started experiencing allergic reactions (swollen mouth/tongue) about 3 years ago while taking Lisinopril. I discontinued that and also discontinued grapefruit juice and things seemed to calm down.
I was switched to Diovan for a brief time and did not experience any epidodes, but because of cost was then switched to Losartin 50 mg daily. I also take HCTZ 25 mg daily and Simvastatin 10 mg daily. I have still discontinued the grapefrut juice but now lately have had episodes of extreme tongue or lips/cheeks swelling. Benadryl seems to slowly take it down, but it is very concerning. Any ideas?
Posted by: Jim | April 20, 2008 12:28 PM
My husband has always been healthy, energetic and strong. A few years ago he was told he had high blood pressure. He ended up in the hospital and almost died because of the medication given (I can't remember the name now). He has not taken medication since until he went to the doctor with severe cough. Once again he was given a blood pressure med called Lisinopril/HCTZ along with antibotics. He got over the cough but just is not himself. He complains of weakness and fatigue and sleeps a lot which is so unlike him! I really wonder if taking this medication is safe.
Posted by: BG | June 29, 2008 2:13 PM
I am a healthy 50 year old female who has taken Lisinopril/HCTZ 20-25mg for about 6 months. My BP was quickly well under control. I have to wonder if some of the people commenting with these problems have a healthy diet, don't smoke, get exercise and maintain a healthy weight. I get somewhat light-headed at times, but no big deal. One glass of wine now makes me tipsy, so I just limit myself to one glass or less, and drink it very slowly. I don't know if the meds have anything to do with the low alcohol tolerance, but that is certainly easy to manage.
Posted by: CH | July 15, 2008 11:20 AM
I would like your advice on reducing cholesterol other than using than statin drugs, to which I have severe side effects. I have tried them all and have severe muscle soreness and know for a fact that it breaks down muscles. I am trying Metamucil daily in hopes this will help my problem. Lisinopril is my high blood pressure medicine and I am taking 40 mg. twice daily. I get plenty of fresh fruits, vegetables and low meat intake. I do aerobic swim classes twice weekly and take supplements. I would appreciate your spin on my problem on reducing cholesterol without poison drugs. Thank you.
Posted by: BH | July 28, 2008 8:15 PM
My husband began taking only 10mg of this medicine. He immediately started having dizziness, loss of appetite, increased urination and general feeling of weakness and confusion. After a few days even after decreasing dosage he has developed severe cramping diarrhea, severe leg cramps, chills, and mental confusion. He also has no appetite whatsoever. Called doctor and nurse said to decrease dose again but I think it is poisoning his system. This drug needed further testing in my opinion.
Posted by: LS | August 7, 2008 6:58 PM
I am a sixty year old African American woman I have been taking Lisinopril for about seven years and for about five years I have been suffering with severe leg cramps if I don't drink maybe 80 ounces of water a day and if I don't start early enough in the day the water won't help.
I have had different test and have been told that the water is the best remedy. I know there has to be a better solution. I am 5'7" tall and weigh 175 lbs.I watch what I eat most of the time. I was told If I lose some weight my blood pressure should go down and I may not have to depend on the blood pressure medicine. Is there anyone out there who can give me more advice
Posted by: sb | August 31, 2008 10:43 PM
I am a 53 year old African American female. When into see my doctor because of shortness of breathe upon climbing steps and tightness in my chest. Had an ECG in the doctor's office and she scheduled a stress the next day. From my resting Echocardiogram the doctor said that I had had ~ 20 -25% reduction in heart function (she called it a silence heart attack). My bp normally runs low and cholesterol level are good.
Then I had a catheter procedure to see if I had any blockages in my heart - no blockages. Since Sept 12, 2008 I was asked to take 5mg of Lisinopril once a day and 3.125mg of carvedilol twice. The doctor said that the combination of these two drugs would help prevent any farther damage to my heart as they look for what cause the attack.
Which they have not found yet. My experiences with these drugs so far have been leg and muscle cramps during the night, some vertigo, I just don't feel right. This is the first time in my life that I had had any type of illness of this nature. I have always been very health I am 5'8", 172.6 lbs. I was 183 on Sept 10th I welcome your comments. Thank you
Posted by: JWT | September 27, 2008 10:08 AM
I have been taking lisinpril for several years but for several months, I have a very dry mouth ; especially at night. Could this be from the lisinopril?I did develop a cough but it seemed to have cleared now.I have sensitivity with my teeth. This dry mouth started on my last prescription--it came from India????? I would appreciate your response.
Posted by: MGH | October 6, 2008 11:06 PM
I am a 30 year old African American Male who has been been taking Lisinopril with Tablup 20/5 for 2 years. Tablup is a diuretic. This medication worked for the first year that I was taking it and then it's effects wore off. I was then prescribed Amlopidine to take in conjunction with Lisinopril. That combo worked for about 3 months and then my BP was back in the 160/90 range.
I'll admit that I don't have the best diet, but I do exercise frequently with cardio and I play tennis.
On the good side, I only experienced one side effect with the Lisinopril and that was sleepiness. But it only lasted for a few weeks.
Posted by: NBL | October 30, 2008 4:44 AM
I have been on Lisinopril 20MG for about two years. I have been back to my doctor 4-5 times complaining about sudden increase in thick clear saliva that while during the day is manageable during the night keeps me or wakes me up from coughing. I find myself clearing my throat continually as well. This has made getting a good night sleep impossible. I have also had period of diarrhea mostly in later morning and afternoon after eating lunch. My doctor keeps on trying me on different allergy medicine and does not think it is the lisinopril. I have never had an allergy in my life! I too think I am being poisoned.
Posted by: JSR | October 30, 2008 9:25 PM
I've been on lisinopril/hctz 20-25 mg. for about 3 yrs. now. I am 55 yrs. old, and have experienced dry mouth, cough, lightheadedness, joint and muscle aches--takes me a while to be able to move after sitting a bit. I am so fatigued and have to push myself to get that walk in. I just want to lie on the sofa and go to sleep when I get home from work. When I first went on this medicine, I experienced numbness and tingling--especially after the doctor added the hctz.
I do not want to feel this way. My doctor tells me not to go off of this medicine. I've changed my diet to fruits and vegetables, walnuts, almonds,high omega 3's, eating coconut oil in place of butter and do not add salt to anything, am walking 2-4 miles four times a week. I truly think I have "white coat syndrome" because it is really high when go to the doctor to get it checked--158/85 when nurse takes it, but when doc comes in, he takes it and it has dropped 30 points. Please, I'm open for any suggestions other than what I'm already doing.
Posted by: jcp | November 18, 2008 9:25 PM