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Generic Name: Lisinopril
Brand Name(s):
Information updated: April 1, 2000
Overview
Prinivil is one of the more recent entries in a class of drugs called ACE
inhibitors.
The development of this group of medications almost reads
like a medical mystery. It all started with the venom of a poisonous Brazilian
snake.
The deadly jararaca caused severe hemorrhaging. An extract from
the venom was found to affect the kidney and ultimately blood pressure
regulation. This led to the creation of enzyme blockers in Capoten, Vasotec and
Prinivil which are revolutionizing the treatment of hypertension and congestive
heart failure.
Prinivil is prescribed to lower blood pressure.
Side Effects and Interactions
People with kidney problems must be monitored
extremely carefully, as Prinivil can make kidney function worse. Even normal
people should have their physician monitor the kidneys periodically.
Prinivil can cause a number of less serious but uncomfortable side
effects. Be alert for an annoying dry cough, skin rash, headache, tiredness,
chest pain, nausea, vomiting, diarrhea, muscle cramps, low blood pressure, nasal
congestion, heart rhythm disturbances and sexual difficulties.
Report
any symptoms or suspected side effects without delay.
There are a number
of compounds that can interact with Prinivil. In general it is important to
avoid potassium supplements, including low-sodium salt substitutes.
Diuretics such as Dyazide,
Aldactazide and Moduretic which preserve potassium can also cause dangerous
elevations in potassium.
Other drugs that can interact with Prinivil
include other diuretics, the arthritis medicine Indocin and lithium.
Check with your doctor and pharmacist to make sure Prinivil is safe in
combination with any other drugs you take.
Special Precautions
The very first dose of Prinivil you take may cause dizziness, especially for older people. Be especially careful until your body adjusts.
When you first start taking Prinivil, be alert for a rare, but serious reaction. Some people have experienced swelling of the face, lips, tongue and throat which can make breathing difficult if not impossible. This requires immediate emergency treatment.
African-Americans may be somewhat more susceptible to this unusual adverse effect. They are also less likely to get the full expected response to Prinivil.
If you are African-American, be sure to discuss benefits and risks with your physician.
Taking the Medicine
Prinivil may be taken with food or on an empty stomach. It should be swallowed at the same time
every day to maintain consistent levels in the body.
Do not stop taking Prinivil suddenly,
as this could lead to complications.
Joe Graedon is a pharmacologist. Teresa Graedon holds a doctorate in medical anthropology and is a nutrition expert. Their syndicated radio show can be heard on public radio.
© 2000