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Generic Name: Lansoprazole
Brand Name(s):
Information updated: April 1, 2000
Overview
Prevacid, like Prilosec, fights acid secretion by blocking the final step.
This so-called proton pump is prescribed for the short-term treatment of
duodenal ulcer, inflammation of the esophagus due to acid splashback, and for
rare conditions of abnormal acidity such as Zollinger-Ellison syndrome.
It is a delayed-release capsule that is extremely effective in reducing
stomach acid.
Prevacid should not be prescribed as maintenance therapy
to keep ulcers from coming back.
Side Effects and Interactions
Prevacid is well tolerated and side effects are
uncommon.
Diarrhea, stomach ache, and nausea have been reported.
Less common were muscle weakness, rash, chest pain, constipation,
gallstones, changes in blood sugar, and elevated liver enzymes.
Report
any symptoms or suspected reactions to your physician promptly.
Prevacid
interacts with very few drugs, but some other prescription medications require
acidity for absorption.
Prevacid can interfere with such medicines,
which include Nizoral, ampicillin, iron supplements, and Lanoxin,
among others.
Vitamin B12 also requires an acid environment for
absorption, and long-term use of Prevacid could result in low B12 reserves. This
may have consequences for the nerves and blood. Please discuss this with your
doctor.
The asthma drug theophylline
also may be affected by Prevacid.
People taking acid-suppressing drugs
such as Prevacid should not take enteric-coated peppermint
oil.
The enteric coating is designed to keep the oil from being absorbed
until it reaches the more alkaline lower intestine. But when there is very
little stomach acid, the enteric coating may dissolve prematurely, releasing the
oil into the stomach.
Be sure to check with your pharmacist and
physician about potential interactions before taking any other medication or
herb in combination with Prevacid.
Special Precautions
Animal studies have shown that Prevacid is associated with a dose-related increase in stomach cancers. It is not known whether this risk also applies to humans.
In addition, because it is so effective at reducing stomach acid concentrations, patients taking this medicine have higher levels of certain microorganisms in their stomachs than would normally survive there. Scientists do not yet know whether these bacteria have negative long-term consequences.
Regular supplementation with vitamins C and E might in theory provide protection against nitrosamines produced by the bacteria.
Taking the Medicine
Prevacid should be taken before meals. These delayed-release capsules should not be opened,
crushed or chewed.
If Carafate is needed, it should be taken at least 30 minutes before
Prevacid.
Joe Graedon is a pharmacologist. Teresa Graedon holds a doctorate in medical anthropology and is a nutrition expert. Their syndicated radio show can be heard on public radio.
© 2000