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Generic Name: Divalproex sodium
Brand Name(s):
Information updated: April 1, 2000
Overview
Depakote is an anticonvulsant prescribed for control of seizures alone or
together with other drugs.
It is also approved for preventing migraine
headaches and for treating manic episodes in people with bipolar disorder.
Side Effects and Interactions
The most common side effects associated with
Depakote include nausea, drowsiness, dizziness, weakness, vomiting and diarrhea.
These may fade after a few days or weeks.
Do not drive, operate
machinery or undertake any activity that requires close attention.
Other
reactions that have been reported include constipation, abdominal cramps, change
in appetite, rash, hair loss, tremor, headache, unsteadiness, hallucinations,
confusion, depression, agitation, lupus, changes in menstruation, and urinary
difficulties.
Report any such symptoms to your physician promptly.
Special Precautions
Depakote must not be prescribed for people with liver disease or reduced liver function.
Weakness, lethargy, feeling bad, swollen face, loss of appetite, and vomiting are possible early warning signs of liver failure due to Depakote and should be brought to the immediate attention of the physician.
Very young children under two years of age are especially vulnerable to liver damage from Depakote.
Depakote has been linked to birth defects. It should be used by women who are pregnant or who may become pregnant only if the benefits to the mother clearly outweigh the risks to the fetus.
Taking the Medicine
Depakote tablets and Depakote Sprinkle are usually taken two or three times a day.
Take them in the same way every day. Depakote may be taken with food, especially if it upsets your stomach.
Carry identification (Medic-Alert) if you are taking Depakote as an anticonvulsant.
Joe Graedon is a pharmacologist. Teresa Graedon holds a doctorate in medical anthropology and is a nutrition expert. Their syndicated radio show can be heard on public radio.
© 2000