Glucosamine and chondroitin are popular supplements for joint pain, but several US studies of these compounds have been disappointing. Even though many people report benefit when they take glucosamine and chondroitin, randomized controlled trials have not shown these supplements to be better than placebo.
European Study Shows Benefit
A new randomized, controlled trial compared glucosamine and chondroitin to the prescription arthritis drug Celebrex, known generically as celecoxib. The study was conducted in four European countries and involved more than 600 subjects with painful knee osteoarthritis.
The clinical trial lasted for six months. At the end, both groups had only half as much knee pain as when they started. They also had less joint swelling and stiffness.
Why the Difference?
We have long wondered why veterinary and European research so frequently shows benefit from glucosamine and chondroitin, while the US trials nearly always reveal these supplements to be ineffective. The authors point out that the European versions of glucosamine and chondroitin are treated as prescription medications and carefully regulated. U.S. supplements may be less reliable.
Based on these results, glucosamine and chondroitin may provide anti-inflammatory pain relief for those who cannot tolerate non-steroidal anti-inflammatory drugs.
[Annals of Rheumatic Diseases, online, Jan. 14, 2015]
Those interested in other non-drug approaches to easing joint pain may wish to read our Guide to Alternatives for Arthritis.
