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Blood Pressure Pill Caused Puzzling Range of Symptoms

Q. I started taking lisinopril for borderline high blood pressure about a year ago. I have had a nagging cough, enlarged tongue and hoarseness for some time.

Last summer I came down with diarrhea that would not go away. My doctor ran tests and prescribed Lomotil. The tests showed nothing.

About a month ago I developed a rash, became adversely affected by the sun and had a very bad pins-and-needles sensation on my skin.

I went to still another doctor and after talking with me for five minutes she recommended I stop taking lisinopril. I was better from day one. Now the rash is gone, I have my strength back and my bowels are normal. I am symptom free and feel like a real idiot for not figuring this out myself. Tell people this medicine can cause some people trouble.

A. Many of the symptoms you experienced (cough, swollen tongue and throat, diarrhea, rash, photosensitivity and paresthesia, ie pins-and-needles) are side effects of lisinopril and similar blood pressure drugs. We wish doctors would recognize such side effects when patients report them. A swollen tongue or throat could become life threatening.

Borderline high blood pressure does not always require medication. As you discovered, such drugs can cause mischief. A thorough analysis by the Cochrane Collaboration found, however, that they don’t offer the expected benefits of protecting against cardiovascular disease and prolonging life unless blood pressure is actually high (Cochrane Library, Aug. 15, 2012).

We are sending you a copy of our book, Best Choices From The People’s Pharmacy, for more information about a variety of options for controlling blood pressure both with and without medication. Truly high blood pressure at or above 160 on the upper number or 100 on the lower number definitely requires drug treatment. If your blood pressure is borderline, though, you might be able to control it with the DASH diet or other approaches. 

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About the Author
Terry Graedon, PhD, is a medical anthropologist and co-host of The People’s Pharmacy radio show, co-author of The People’s Pharmacy syndicated newspaper columns and numerous books, and co-founder of The People’s Pharmacy website. Terry taught in the Duke University School of Nursing and was an adjunct assistant professor in the Department of Anthropology. She is a Fellow of the Society of Applied Anthropology. Terry is one of the country's leading authorities on the science behind folk remedies..
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