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911 Leaky Gut and an Immune System Run Amok

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click here if you cannot view audio player: PP-911Immune.mp3

Tune in to our radio show on your local public radio station, or sign up for the podcast and listen at your leisure. Here's what it's about:

Susannah Meadows's son was only three years old when he developed terrifying symptoms of a disabling disease, juvenile idiopathic arthritis. His parents were frantic to help him feel better, but conventional medicine was slow to go into effect. They decided to explore an alternative approach as well. Could dietary changes have an impact on an immune system gone awry? Find out about the clinical basis for the link between leaky gut and sore joints.

 Guests: Susannah Meadows is a journalist who writes the Newly Released column for The New York Times. Her article, "The Boy With a Thorn in His Joints," was published in The New York Times Magazine on February 1, 2013.

Leslie Mendoza Temple, MD, is Director of Integrative Medicine at North Shore University Health System in Glenview, IL, and Assistant Professor of Family and Community Medicine at Feinberg School of Medicine of Northwestern University.  Above photo is of Dr. Mendoza Temple.

The podcast of this program will be available the Monday after the broadcast date. The show can be streamed online from this site and podcasts can be downloaded for free for four weeks after the date of broadcast. After that time has passed, digital downloads are available for $2.99. CDs may be purchased at any time after broadcast for $9.99.



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  • Currently 4.5/5
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Did you enjoy this radio show? Average rating: 4.5/5 (115 votes)
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Considering a previous very interesting couple of shows on the microbial ecosystem of the intestines, this approach really makes very good scientific sense. The Professor from NCSU comes to mind. And the show about Fecal transplants also I think reinforces this approach.

Understand, I am not an MD, but my job is to maintain a huge digestive microbial mix to digest wastewater. We in the industry call it the Mixed Liquor :). It is essentially our job to make sure conditions are maximized to make sure a healthy mix of thousands of different microorganism. It is such a complicated ecosystem that no one really does not fully understand it, but one does know when it is working correctly and when it is not. When not, one then systematically tries to figure out what was changed.

Interesting stuff.

In my early 60's I developed arthritis in my hands, shoulders and knees.

I read Dr Esselstyn's book on Reversing and Preventing Heart Disease and decided to become a Vegan. Also I eliminated Gluten from my diet.

My Arthritis symptoms went away after I became a Vegan and stopped gluten intake. I did a Google search and discovered a research study in Stockholm Sweden that showed similar results.

This show was very informative and interesting. I really appreciate it!
I have had some issues that continue to return and after hearing some of the symptoms I will check it out with my doctor.

This show was very informative; the Dr. Temple's information was most helpful; Susannah Meadows' methodical approach to healing her son, which must have been truly an emotional rollercoaster ride, caught my attention. Excellent show. Your questions were on the mark, timely and unobtrusive. We needed for these folks to talk, and you let them do so. Very helpful.

Very informative show. I have ulcerative colitis and was only able to get it under control after following Brenda Watson's recommendations which included high doses of fish oil and probiotics. I am now starting to develop joint pain which I suspect may be ankylosing spondylitis. I will definitely be looking into Dr. Mendoza Temple's regimen for myself.

Excellent show! Thanks!

On the show, Dr. Leslie Mendoza Temple, MD, recommended 3 strains of bacteria for Shepherd (The Boy with a Thorn in His Joints): Lactobacillus Rhamnosus, Saccharomyces Boulardii, and Lactobacillus Acidophilus. I have found that many products contain Lactobacillus Acidophilus and Lactobacillus Rhamnosus, but do not contain Saccharomyces Boulardii. Jarrow makes a probiotic that just contains Saccharomyces Boulardii and MOS. Per the Jarrow website, "MOS is an oligosaccharide from the cell walls of S. cerevisiae that can discourage bacteria from adhering to the epithelial cells and reduce the proliferation."

So I have a couple of questions;
1. Would Dr. Leslie Mendoza Temple, MD, be willing to mention the brands of probiotics that her patients have had success with?
2. What does Dr. Leslie Mendoza Temple, MD think of MOS? Does the presence or absence of MOS affect the probiotic? If yes, how?

Leni Reed Nazare

It has taken me about 20 years, 4+ hospital facilities, innumerable Drs. to assemble the info in your excellent presentation & I can't express the depth of my Appreciation!!! I don't know how podcasts or streaming online function so I may have difficulty following thru with a backup.

My doctor is treating my cerebellar ataxia by working on my leaky gut. He also recommended a vegan diet. I regained a year of neurological health immediately, and have gained maybe 3 years of nero-health in 2 months. So this leaky gut may have neurological implications as well.

I have had the mannitol-lactulose test and was found to be highly positive for intestinal permiability.

I have struggled with fibromyalgia/chronic fatigue for close to 30 years and have had digestive disturbances my entire life with an irritable bowl diagnoses as well. I am on an elimination diet of sorts,i.e.; gluten-free, grain-free, even copper-free for a time, dairy-free as in no milk but I do have cheese with an emphasis on raw goat cheese.

I have two questions for Dr Mendoza-Temple: does cheese that is aged still have lactose so that it indeed needs to be eliminated on the diet? and has she ever had patients that developed severe skin irritation/itching in and around the anus/rectal and groin areas as a symptom connected with IP? Thank you!

I have recently caught your show on Leaky Gut Syndrome and really heard some valuable information. I have battled stomach problems for many years, been on Prilosec but wanted to get off these drugs. This is very hard to do as my old symptoms of heart burn and all that goes with it has came back.

It just makes me so mad how our AMA is so corrupt along with our law makers who pass these drugs on through just for the money they will make, knowing full well how dangerous lots of these drugs are for us. I think we should really watch who we elect to offices and get these corrupt people out of there.

At any rate I love Public Radio and have supported them and listened for the last 7 years, thanks to my great Guy friend who turned me on to the Public Radio stations. Keep up the good work.

I suffered from repeated urinary infections over many years, then the acute body pains started: I practically lived on antibiotics.

After a lot of research, I became vegan, started a regime of probiotics and omega-3s etc. Have not had a urinary infection in seven years.

Your program on Leaky Gut was fascinating and I learned a great deal.

In addition, I have been dismissed as a patient by three doctors because I refused statins!
I am not medical, just an aging woman who becomes incensed because doctors have stopped listening and all I seem to hear is, " well, at your age....!".

One may be aging, but that does not mean that we should be dismissed out of hand.
Thank you so much for your work. I am a big fan!

I'd like to hear medical evidence/info re: the relationship between H pylori, the powerful antibiotic regimen to eradicate it and subsequent Leaky Gut -- does the antibiotics used to kill H pylori lead to a permeable gut lining?

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