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Zolpidem Has New Dose for Women

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The popular sleeping pill zolpidem was first approved by FDA in 1992 under the brand name Ambien. Last year nearly 40 million prescriptions for this medication were dispensed.

Last week, the FDA announced a change in dose for women. Instead of the usual 10 mg dose, women are instructed to stick to 5 mg of the instant release forms of zolpidem. The FDA has also suggested that women taking the slow release formulation of zolpidem (Ambien CR) not exceed a dose of 6.25 mg.

The reason for this change is a recognition that many women end up with higher blood levels that persist longer in the body. The agency has received more than 700 reports of "impaired ability and/or road traffic accidents" associated with zolpidem. The morning hangover effect may impact judgment and reaction times. Some men may also do better on the lower dose of this medication.

You can read some scary stories from readers about their experiences sleep-driving while taking this drug.

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15 Comments

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So, the dosage of something that, taken correctly, works very well for many people (including me) will be halved because some people experience problems. What about the issue of not getting sufficient sleep during the workweek? I've tried 5 mg and it doesn't work for me. What will I need next, the drug that keeps you awake for a workday?

I have taken ambien and later zolpidem 5 mg since 2008 with no adverse effects. I am an 88-year-old female.

Good grief! Can't people take a certain dosage and see for themselves if it works correctly or as needed, and adjust the dosage accordingly? Sheesh.

I'm wondering how long "longer" is. Without more specific information, this seems pretty arbitrary to me.

I have a 'script for the 10 mg pill, but generally 1/2 (5 mg) works for me.

Shouldn't this be prescribed by the individuals body weight? 10 mg for a 110 pound female is different than 10 mg for a 200 pound female.

I have been taking 20mg of ambien for over 15 years, I am the worlds worse insomniac, I wake up refreshed, ready to "tackle" the day, ambien has "saved my life and I will interview MDs who will agree we are ALL not the same, but we admits what helps us!!!

I am an extremely responsible person, I was "blessed" by the manufacturer that "discovered Ambien, I was such a "horrible insomniac, I took 20 mg for over 15 yrs without any issues, now, my marriage will be destroyed from lack of sleep, ? job suffer? on and on on, this should be a case-by- case basis, not "everyone grouped together!!! THINK OF WHAT YOU ARE DOING!!!

I think this is discrimination. I am 5' 9" and weigh 165 lb and am female. So I can only get 5 mg from the VA? I am a retired Air Force major and have been prescribed 10 mg a day for many years! What a surprise when I called my VA hospital and told them I was mistakenly prescribed 5 mg only to be told this BS by the VA pharmacy.
I told the VA pharmacist that this is discrimination and I will call the FDA. I think she thought I was crazy!

This morning I am tired, achy and angry. Because of my gender my poor health from lack of sleep is returning to what it once was before my doctor prescribed Ambien. The dosage of 6.25 mg is not working for me. I've always taken the 12.5 mg of medication responsibly, allowing 8 hours for sleep. I used to awake feeling refreshed and ready to go. Now I awake feeling tired from lack of sleep, my joints and muscles ache, my eyes are bloodshot and I'm angry.

Simply using gender as a determination for dosage is using a broad paint brush and irresponsible. Come on FDA you can do better.

Ive taken 10mg for years with no problems. I am 39yrs. and female. Now I have to take 5mg that just does not work. That's not fair. They should go off of weight.

I am in the same boat I have been taking 10mg for 10 years what now no sleep for me? Do we have any recourse or is this "just the way it is"?

I am a 65 yr. male having been on AMBIEN for about 10 years w/out any side effects.(12.5mgCR) extended release. While I researched this issue for my lady friend I was surprised @ the info re: slow release from the body into the next day which is apparently different than men. So I will tell her what I found out but I want to remind all forward thinkers that "Your doctor has a BODY OF KNOWLEDGE, but you have KNOWLEDGE OF YOUR BODY." We are not all the same. Use common sense with this.

I have been taking Ambien for about 2 years. For the prior 3 years I had no idea that you could take something to help you sleep. I woke up 30 to 40 times every night and that just became my new normal. Now with the help of Ambien I only wake up about 5 times a night. I have been taking 10 mg and my Doctor had told me to not take it 1 out of the 7 nights a week so my body won't get to used to it and in turn it will keep working. But on that 1 night a week with out Ambien I just laid in bed for hours. I usually fell asleep around 4 am but may times it was 7 am. So after 1 year of that I just took it every night. I have been on the new fda 5 mg only for the past 4 days and the 1st night I fell asleep at 5am 2nd night 4 am 3rd night 7 am and here I am at 5:30 a.m. looking on line to see and I the only one that with the new fda 5 mg only law can't fall asleep. I am so f------- a wake it's not funny and yet soooo tried after the 4 hours a night I am getting now. If 2 mg worded I would be happy to just take that. But maybe the fact that I am 210 pounds might be why. I guess if I loss 100 pounds maybe the 5 mg may work. lol NOT !!! So can any one tell me did the fda tell doctors this is recommended or is it the law ? Can a doctor order more that 5 mg for a woman if he knows 5 mg will not work ??????

I believe that people should listen to the doctor when they say to take this at bedtime not in the morning. I have a RSD. Bad nerve con. My doctor put in AMBIEN 12.75 Most of time pains is to bad that wakes me up. Now since the new law pass only for women 5mg. I was very upset because of my RSD. Now I have to take 5mg and with it two EQUATE PM. And 5mg DOES NOT DO GOOD ME.

I am 66 year old woman. My new doctor won't prescribe me Ambien, not even 5mg because I am over 65. I have been taking 5mg for 6 years, I always wake up refreshed with no side effects whatsoever. He gave me Restoril instead, because he said that's what they give patients in the hospital. This did a terrible job on me, I woke up with a terrible headache that lasted all day and I was so tired all day I could not function properly. This never happened to me with Ambien. Before I took Ambien I tried all kinds of over the counter herbs and potions and nothing worked as well as Ambien.

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