A bottle of generic delayed-release Duloxetine (Cymbalta) 30 mg

Cymbalta was originally approved by the FDA in 2004 for the treatment of major depression. It is officially an SNRI-type antidepressant. In doctorspeak that means it is a serotonin-norepinehprine reuptake inhibitor and is somewhat similar to other antidepressants such as Effexor (venlafaxine) and Pristiq (desvenlafaxine).

The FDA also approved Cymbalta to treat nerve pain associated with diabetes in 2004. In 2007 the drug got a green light for anxiety and in 2008 the FDA agreed that it could ease the discomfort associated with fibromyalgia. It was also approved to treat musculoskeletal pain associated with arthritis and lower back pain in 2010. In other words, here was a drug that could relieve your blues and your aches and pains. And the drug company that makes Cymbalta (Lilly) has been aggressively marketing it as a good way to deal with chronic low back pain and osteoarthritis. Perhaps you have seen the commercials on TV promoting the pain relieving power of the drug with the slogan “Cymbalta can help.” It sounds almost too good to be true.

Ah…and there is the rub. Although there is a long list of serious side effects mentioned during the commercial, the video images seem quite reassuring and trump the scary message the FDA requires for this medication. So, let’s set the record straight. Here, without visual interference, are a list of potential complications associated with this medication.

Cymbalta (Duloxetine) Side Effects

  • Nausea, stomach pain, constipation, diarrhea, decreased appetite, vomiting
  • Dry mouth
  • Insomnia, anxiety, tremor
  • Dizziness, fatigue, sleepiness
  • Sweating, hot flashes
  • Blurred vision
  • Headache
  • Sexual dysfunction, lowered libido, erection difficulties, lack of orgasm
  • Liver damage
  • Serious skin reactions, rash, hives (requires immediate MD assistance!)
  • Glaucoma
  • Irregular heart rhythms
  • Bleeding problems
  • Blood pressure problems
  • Interaction with other drugs (leading to serotonin syndrome among other reactions)
  • Pneumonia
  • Seizures
  • Depressed mood, suicidal thoughts and behavior, suicide

Such a long list of side effects makes your eyes glaze over after the top 3 or 4. That is why we have included stories from real people so you can better understand what these complications feel like.

Even though such side effects are scary, there is another problem with Cymbalta. When people try to stop taking this drug they frequently report unpleasant withdrawal symptoms. An organization (QuarterWatch) that monitors the FDA’s database of serious adverse drug events has noted that:

“We observed a signal for serious drug withdrawal symptoms associated with duloxetine (CYMBALTA), a widely used antidepressant that is also approved to treat arthritis and back pain, anxiety, and fibromyalgia. In the first quarter of 2012 the FDA received 48 case reports of drug withdrawal identifying duloxetine as the suspect drug. They described a wide spectrum of withdrawal effects that began when the patients stopped the drug, including blackouts, suicidal thoughts, tremor, and nausea. Several cases involved hospitalization.

Probing deeper into the scientific record for duloxetine we found that withdrawal symptoms were reported in 44-50% of patients abruptly discontinuing duloxetine at the end of clinical studies for depression, and more than half of this total did not resolve within a week or two. In addition, we identified a serious breakdown at both the FDA and the manufacturer, Eli Lilly and Company, in providing adequate warnings and instructions about how to manage this common adverse effect.”

Doctors have taken to calling this “discontinuation syndrome.” These clinical words do not do justice to what it is like to stop antidepressants like Cymbalta, Effexor (venlafaxine), Paxil (paroxetine), Pristiq (desvenlafaxine) or Zoloft (sertraline) suddenly.

Sudden Withdrawal Symptoms

  • Brain “Zaps” (electric shock-like senstations in the brain)
  • Dizziness, light-headedness, vertigo, feeling faint
  • Headaches
  • Anxiety, irritability, hostility
  • Nausea, diarrhea, digestive upset
  • Tremor, hands shaking, nerve tingles, strange sensations
  • Fatigue, tiredness, lack of energy
  • Visual disturbances

Again, a list of symptoms does not do this problem justice. Below you will read some stories from people who have posted their comments to this website. We would love to hear your story, positive or negative. Share your experience with Cymbalta or any other antidepressant below.

Should you wish to learn more about dealing with depression through some other strategies, we offer our Guide to Dealing with Depression. You will also find a whole chapter on prescribing mistakes doctors make when treating depression and fibromyalgia in our book, Top Screwups Doctors Make and How to Avoid Them.

Cymbalta Withdrawal Stories from Readers

“My lovely, young daughter-in law, who was about to celebrate her 29th birthday, was prescribed Cymbalta, Klonopin, and Ambien and has committed suicide.

“She told her physician and her therapist that she’d had thoughts of suicide but no one took her seriously. She suffered from depression, as well as an eating disorder, and had very low body weight. She also used alcohol.

“Please remind your readers of the potentially disastrous effects these chemicals can cause when taken carelessly or in combination with alcohol.”
– D.G.

“I have been on Prozac over the last 20 years off and on and it finally stopped working. The last time I took it about 2 years ago I was taking the generic from Barr – the blue and white capsule. I was feeling as if I were in the deepest dark hole there ever was.

“My doctor put me on Cymbalta from which I had a lot of side effects such as palpitations, feeling constant dread, panic attacks, sweats, lightheadedness and general feeling of not being well.

“She added Abilify which put me over the edge. I was in the worst depression I have ever been in. Finally after living like this for several months, I asked to be put back on Prozac. I was taking the generic from Sandoz. When the prescription ran out I ended up on the big blue and white capsules from Barr.

“Over the last couple of weeks it has been constant crying spells, arguing with everyone and feeling pretty low. I talked to my doctor and she wrote the prescription for Sandoz only generic. The blue and white capsules are like taking a placebo. My doctor said she had had other patients who complained of the same thing and she had to write prescriptions for a certain generic or name brand.”

– P.J.

“I took Cymbalta for 3 days and thought I’d go nuts. I’m off it now and refuse to try any other drug like this. My main complaint was extreme hot flashes that estrogen wouldn’t help. I thought I’d be given Prozac, but was given Cymbalta instead. It was a rough 3 days and I stopped it last night. I am extremely tired yet cannot sleep at night. I think I was sweating even worse and my legs started feeling like I had Lyme disease again. And to be honest, within those 3 days of taking it, I didn’t contemplate suicide, but I had this crappy attitude of “who would care?”

– R.P.

“It took me 18 months to get off Cymbalta, with no doctor’s help. I can hardly believe that doctors have no exit strategy for this dangerous drug. I had to find this out on my own from reading and as soon as I weaned off that – about a month, the tinnitus that had occurred decreased almost completely. No doctor told me this.”
– Nancy

“My daughter experienced severe side effects when trying to come off Cymbalta – she had nausea, vomiting, lost peripheral vision for 24-48 hours, had shaking, etc. This was while she was doing a clinical in a hospital for college. Had she known she would have stayed on it until after clinical. I called the manufacturer and they acted like there were no such side effects from withdrawal.

“She too took apart the capsules and it took awhile, but finally she is free from that drug. I think it is a crime that the manufacturers don’t publish more detailed information concerning withdrawal. They could even make money selling a one month or two month step down prescription so individuals aren’t taking the capsules apart themselves.”
– J.K.

“I just turned 52 today. I went on a very low dose of Zoloft about 8 years ago to treat generalized anxiety disorder. It really did help for a long time. I recently have been pretty depressed (however I can cover it up really well) and my psychiatrist switched me to Effexor which was terrible for me. Now I’m trying Cymbalta which has not done anything either except make me feel more anxious and headachy and weird.”

“I am a registered nurse and I do not understand what the long term effects of these meds are and I am concerned. I really want to get off and see what I can do naturally for myself.”
– P.C.

“Getting off Cymbalta is challenging but not impossible. I, too, experienced the light-headedness, dizziness, and “brain zaps.” I described it as being able to “hear my eyes move.” It sounded like the light sabers on Star Wars. Very strange and disconcerting.

“The key is to do it very very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.

“Your doctor will probably be no help at all. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more. Be patient. I am completely off now and feeling GOOD.”
– K.T.

“I took Cymbalta for fibromyalgia and have just stopped taking it because of acute liver and GI pain- yes, pain! My liver poured bile into my gut and protested loudly! Cymbalta worked great on the fibromyalgia, but I had to stop.

“I agree that doctors don’t always realize how prescription drugs can alter your life so we must continue to advocate for ourselves.”
– V.C.

“I was prescribed Cymbalta ‘off-label’ to manage fibromyalgia pain When I stopped taking it because it wasn’t delivering on the promised effect of reducing my pain, I became so horribly depressed that I required hospitalization as I had become SUICIDAL!

“I will NEVER take another anti-depressant for an off-label purpose….such as Elavil/amitriptyline as a “sleep aid” which is very commonly prescribed.

“I believe it should be criminal to prescribe ANY drug for a purpose other than the one it was approved to treat.”
– Karen

“I’m a 76 year old man, my libido was very low. Taking Cymbalta for peripheral neuropathy added ED as a side affect of the drug. I had a testosterone blood test; it was 1/3 what the minimum should be. So I’m taking Androgel to raise testosterone levels and it is magic. I have great libido now and am working on minimizing the Cymbalta pills. In the meantime I have been prescribed Cialis for the ED. Each pill solves the sex problem for a couple of days.”
– R.H.

“I have the exact symptoms as everyone else and it’s been a week. I only took Cymbalta for 2 months, but the side effects from stopping it are horrible. My doctor didn’t, nor did anyone else tell me, about any side effects and I did read the insert. Most of the time the listed side effects of meds don’t bother me, so I figured no problem.

“From reading other posts on this website and on other sites, the drug seems to affect every person the same way. I would never have taken it for my neck pain if I had known about the likelihood of side effects. The worst part for me is the dizziness, the brain zings and the sudden burst of tears for no reason. I would never take this drug again. I think the FDA needs to do longer studies on all drugs and be honest with their findings and that doctors should be honest and tell their patients what really happens when you take Cymbalta.”
– M.O.

Please add your own experience below in the comment section.

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  1. Amanda
    Knoxville, TN
    Reply

    I had my first panic attack when I was a senior in college. I thought it was a bad reaction to pot, ignored it, and fast-forward a few years later, I was diagnosed with Panic Disorder. Nearly 15 years after that, people still have a hard time believing that I have Panic Disorder; I’m successful, calm, manage a large company. . . none of that matters, and none of that has anything to do with my Panic Disorder.

    I was initially prescribed Effexor, which was awful for me – I felt drugged and hated it. I tried natural remedies – St. John’s Wort, Vitamin B, self-help guides. . . nothing worked. After reaching a terrible point, I was prescribed Paxil, which helped me a lot. I took Paxil for over a year, felt great, and stopped taking it. Within a year, the panic attacks were back, and I was prescribed Cymbalta 60 mg. Like Paxil, it worked for me, but it had the same terrible long-term side effect. . . no orgasm. I tried Wellbutrin, but that was as awful for me as Effexor. I went back to Cymbalta, took it for a couple of years, felt great again, and stopped taking it (3 days of “brain-zing” were normal for me.)

    Almost six years med-free, my attacks were back. I was put on the generic Cymbalta (Duloxetine,) and it took two solid weeks to get past the side effects. I don’t remember Cymbalta causing the same side effects, but that could be my brain playing tricks on me. I spent the first several days with a terribly dry mouth, sweating like a pig, and feeling anxious. By the second week, the dry mouth was better (still had a new, odd metallic taste in my mouth,) less sweating, but I still felt agitated (I don’t have nervous leg syndrome, but I imagine I was experiencing close to the same.) By the third week, almost all side effects were gone, and I felt panic free.

    Bottom line – whatever your diagnosis or condition, try your meds. Share your condition. Research it, know it, share your knowledge… get those around you past the stigma of mental illness. Be ready for possible weird and scary side effects of your meds. Give them a chance. When they absolutely don’t work, they’re a nightmare, and I know it. Go back to your doc, and tell them “hell, no. Something else, please.” If you don’t have insurance or that option, research other options. Until we get everyone to take mental health issues as seriously as any other health issue, we have an uphill battle. Think about alcoholics a few decades ago – they didn’t have a substance abuse problem, they were “drunks” or “good for nothing.”

    You can be strong, successful, brilliant, fun, energizing, eclectic… you can be all these things and still have a mental illness. You can be none of these things and have a mental illness. Treatment is paramount: be it with the SSRIs, SNRIs, therapy, a combo of both, holistic meds… Whatever works for you. But no matter how alone/exhausted you feel, know that something WILL work for you!!!

  2. CJ
    United States
    Reply

    I have been on and off of anti depressants for 20yrs, the last 10 I have been on Cymbalta for fibromyalgia and low back pain (disc issues). When the generic came out I ended up extremely sick and back to suffering stroke like migraines, the Dr then put me back on Cymbalta brand which she then placed me on topamax to help with the migraines, oh BTW my hair started falling out and I had short term memory loss (real grand when studying college courses). I’m off of the Topamax. I no longer want to take the Cymbalta, but each time I’ve tried to come off of it I suffer from a multitude of side effects. I am beginning to think it also has something to do with me having to intermittently use urinary catheters. I started 2 months ago by opening the capsule and currently I’m taking 20 beads out per day. I’ve read hopeful stories on here, thank you. I’m afraid by taking the meds I have done long term damage to my system and it won’t be able to come back into balance. Any advice or guidance is appreciated.

  3. Donna
    Tennessee
    Reply

    Been on Cymbalta 60mg for 8 yrs. For depression. Wanted to come off meds due to changes in life. Dr put me on 30 mg for 2 weeks and then for two weeks a 30 mg every other day. Not sure how I’ve survived last 17 days especially going to work every day. But I will never take antidepressants again. Would rather cry! I’m just living one day at a time and praying for relief from this demon!

  4. Lindsey
    MN
    Reply

    Please read, need advice. I’m 20 years old and I was prescribed Cymbalta for depression about 4 months ago. The first few days were terrible with extreme hot flashes or even feeling hot the entire day. It also made my nightmares worse and just made my depression worse in general. 2 days ago I decided I needed to stop taking it so I quit cold turkey thinking it would be easy like the 2 other meds I have tried. I’m having brain zaps every time my eyes move from side to side. They are so intense my shoulders and chest muscles twitch. My nausea level is beyond a 10 but I can’t throw up. Now that I am reading all these comments I am scared that I will be like this for over a month. I can’t afford to stay on it though because every months worth costs $90 for me and I refuse to pay for something that makes me hate my life. If anyone has had experience quitting cold turkey and it was dangerous for them please let me know.

    • Mumin
      ohio
      Reply

      Sorry be careful with Cymbalta don’t stop without reducing the dose or you will suffer. It takes long time to leave your body. Go back to your doctor tell him otherwise you will suffer. I took it 4 year ago I did same as you I stopping suddenly I suffer very long time.

  5. Ech
    Southend
    Reply

    I have been taking duloxetine for 2 years. I have been on a reduced dose from 60mg to 30mg for 5 weeks and it’s horrible. I keep getting headaches, feeling so tired but not being able to sleep due to bad chest pain (only had chest pain since coming off). I feel irritable and anxious and can’t seem to calm down. Will be phoning the doctor later to see what they say. Will not be going back up but surely this can’t be right!

  6. Kyle
    Austin, TX
    Reply

    I have been on Cymbalta 120mgs for five years as someone who suffers severe anxiety and breakthrough pain. There was a time about 2 years ago when I wanted to try a different med, so I began Prozac and was off the cymbalta. For that entire month my heart hurt like I was going to have a stroke or seizure. For THREE years I have stayed on this med all because I am so scared to get off. I had tried by taking pellets out but it is such a long and hard process.

    I am going to my doc and will ask to go to 90, then 60, then take out pellets until I can get to 30, and then take out the pellets slowly. I expect it to take 2 years but I am no longer depressed and my anxiety is better managed by another med I’m taking. I never knew how dangerous getting off of it was until that month I felt like heart attacks would happen. My psychiatrist told me and then I realized. I had a “I’ll just take it forever” mentality but I am 23 and don’t want my liver to fail in a few decades. I don’t think Cymbalta should be on the market and I think they need tablets so people can dissolve them in water and taper. To me this med is the devil and it’s never ever worked on me. I want to try Lexapro but am limiting myself to maybe 20mgs max. And that’s only if I’m depressed again. My anxiety is being dealt with by benzo’s (Xanax and Valium which I will never get off of because the effects are terrible and every attempt has led to a seizure.) At least the stupid benzos have helped. And then the right way: seeing a psychologist!

  7. Jenny
    Reply

    Cymbalta is truly the worst drug that ever existed. I wish doctors would go on it and try to wean off. These symptoms described above don’t take time to set it. If that drug is not in my body within 24 hours I literally get the brain zaps and get sick. I’ve tried to wean off. It’s just too much. They put me on it bc I was about to begin a divorce and he thought it would be best to control my up and down behavior. Zoloft was much gentler. I have the craziest dreams the first night after not taking it. I have night sweats. Lilly should be responsible for what they’ve done.

  8. Sherry
    Denver
    Reply

    I was prescribed Cymbalta for Fibromyalgia and depression by a PA at a pain management clinic through a chiropractic office. I did not feel any improvement with this drug but she wanted me to “give it time”. The clinic abruptly closed down the pain management without notifying patients or referring to a new provider. I found a REAL pain management doctor who is also an Anesthesiologist. He wanted me to titrate off Cymbalta while titrating up on Savella. I feel much better on the savella, but the withdrawal off the Cymbalta has been a nightmare! I’ve had panic attacks, anxiety, weight loss, nausea, horrible hot flashes, chills, feelings of electrical pulses and the list goes on. I’ve been titrating down off Cymbalta for 5 weeks now and I feel like this will never end. I’ve contemplated going to the ER 3 times and have called my doctor in a panic. I’ve also started seeing a counselor because the Cymbalta titration threw me into serious, deep, dark clinical depression worse than anything I’ve ever experienced. At moments I’ve literally felt as if my mind is fracturing and falling apart.

  9. DJ
    Reply

    I wasn’t voluntarily taking myself off cymbalta, my mail order prescription company sent it to some other (unknown) address and told me that to get a month supply of ‘fill the gap’ pills at the pharmacy would be a cool $160. So I decided to stop taking it until my next shipment came in.

    The first week I didn’t even notice it. This second week has been hell on earth. I’m in need school and all I do is cry- before class, in breaks, at home, in the car- all for no reason at all. I’m all in edge and constantly have terrible thoughts racing through my mind.

    Just when I get a medication combination that manages my bipolar disorder (managed for over 6 months now) the damn insurance company rips that away from me. Now it’ll be another month before the medication re accumulates in my body and I will actually feel normal again.

  10. P.O.
    Louisville, KY
    Reply

    I had been on cymbalta (60 mg.) for several years. It helped my depression and I suffered no side effects. For the last several months, it seemed my depression had returned. I spoke to my doctor about this. He prescribed wellbutrin and told me to take both medications for a month or so until I felt better – which I did. Then he gave me strict instructions to decrease the cymbalta. He prescribed 30 mgs. daily for 2 weeks, then every other day for 2 weeks, then twice a week for 2 weeks. I have followed this program. Even doing this I have experienced some of the side effects – but not severely. I was very relieved when I read this article and the experiences of others, since I was feeling that there was something wrong with me. Now that I know these brain “zaps”, queazy feelings, anxiety, etc. is from going off cymbalta, I feel that I can handle it better. I never had these symptions with other antidepressants. This stuff is pretty serious. I’m thankful my doctor was aware of it.

  11. Shelby
    Hawaii
    Reply

    Hi there, I have been taking Cymbalta for about 3 months now and was really hoping that it would help me with my Fibro symptoms. It didn’t help AT ALL!!! I however found a natural solution that has been working wonders for me!!! Thank God!!! So I decided to try and stop taking Cymbalta. Also Cymbalta can be very damaging to one’s liver and I have problems with my liver already. My Dr prescribed Cymbalta to me, know of my liver issues, without even warning me about this!!! I think that should be illegal as this drug could have sent me into liver failure. So I have been trying to wean myself off of this drug for a couple weeks now and have been having some off the worst withdrawal symptoms! I tried to stop cold turkey but knew I would end up in the hospital that way because the symptoms were so bad that I was curled on in a ball on the floor shaking and crying. My husband told me that I needed to wean myself off of it instead of going cold turkey. My symptoms have included: Extreme mood swings, migraines, head “zaps” (it feels like painful electricity shoots through my head to my upper back or visa versa), nausea, brain fog, chest pains that have put me in tears, trouble sleeping, body cramps, diarrhea, shakes/tremors, and a general feeling of discomfort and pain. This is a seriously horrible drug! If you are on this site and considering taking Cymbalta, please, I beg you, DON’T!!! I can’t believe this stuff can legally be prescribed!

  12. M.L.
    Toronti
    Reply

    I’ve had fibromyalgia since 2003 and managed the pain mostly through exercise and half a Flexeril when I was I huge pain… But then My dad had cancer and passed away and I developed anxiety as a result. I didn’t want to take any medication, but my doctor convinced me to take 30 mg of Cymbalta for my anxiety and Fibromyalgia. It was my worst decision ever! I took it only for two weeks and I was itchy all over my body. My brain also felt like it was dividing in two and I didn’t feel all that great. I didn’t feel anxiety though, so I guess it did help with that, but I decided to stop it after scratching myself so much. I haven’t taken it in 3 days and the itch is subsiding, but I have severe diarrhea… I strongly do NOT recommend this drug to anyone!

  13. Sharon
    Highfields australia
    Reply

    I have been told to stop Cymbalta 30mg. I did this cold turkey. Severe nausea, headaches, and anxiety r but a few of the side effects. I am not confident to drive at the moment. I thought my head was going to explode. Never had such bad headaches and nausea. I was not told to slowly come off the medication or that I would have any side effects. Had I known of the side effects involved, I would never have taken Cymbalta. Side effects worse than the depression. Severely affecting my daily life and family. Totally irrational at times. Can’t wait to feel human again. Tried lots of other antidepressants but had bad side effects. Cymbalta was the only one that did not give me incontinency as a side effect. Going to try diet, exercise etc and no meds if possible. Do not want to have to go off meds with side effects again. Brain zaps are the worst. Constant nausea is horrible. Putting off doing fun things because I do not feel well. It must be frustrating for my family. I am surprised my husband is still here.

  14. mya
    ohio
    Reply

    Cymbalta really does help me with my depression however if i forget to take it once, I’m sent right into withdrawal symptoms and the ones listed here are right on!! The “brain zaps” and dizziness are the worse!! I’m on 60 mg per day to manage my depression as well as my crohns and IBS with constipation. I cannot function digestively without it!

  15. Sarah
    Toronto
    Reply

    I am a 24-year-old female, and I have suffered from anxiety depression since my early teens. I first tried Cipralex for about a year, and all it did was make me feel sedated. My doctor then changed my prescription to Cymbalta and instructed that I take one 30 mg capsule a day for one week, then change to two 30 mg capsules a day. I could hardly handle the symptoms after the first week – could not get any sleep, was swimming in my own sweat every night, had horrible tremors, etc.

    I kept pushing through at 30 mg a day hoping it would kick in eventually, and I found it worked surprisingly well after about a month. I had less anxiety and more energy than usual, which I used to keep myself busy with my studies (college student). The side effects became less noticeable over time, and I had my first full night’s rest on the day I went back to see my doctor. I gave her a status report and she shakes her head at me – tells me, “30 mg shouldn’t do anything for me.” She didn’t take me seriously at all – as if 30 mg of Cymbalta merely had a placebo effect. So she sent me home, telling me to start taking 60 mg and to see her in another month, which I did.

    The side effects were x10 worse. I thought my heart was going explode in my chest. My body shook uncontrolably. I couldn’t even sit still let alone get any sleep. I had to change my bed sheets every night because they would be drenched in sweat. I immediately stopped taking Cymbalta after just 3 days of 60 mg. Coming down from the drug, I had extreme fatigue, headaches and nausea. I did not get out of bed for an entire day. After two days of misery I picked up 30 mg to try and find some “normalcy” again.

    Since I have been prescribed 60 mg capsules now, I have taken to twisting them open and emptying its contents by half. Realizing how horrible the discintinuation symptoms were encouraged me to come off of it entitely. Gradually I am reducing the amount of pellets I leave inside the capsules. I decided to write this comment here and now because I had fogotten to take my reduced dose for a couple days now, and I had violently woken myself up from a disturbing dream – which has happened multiple times in my attempts to come off of Cymbalta. I wanted to see if anyone else had had disturbing dreams as a discontinuation symptom

  16. John
    Manchester UK
    Reply

    Hi,

    I’ve had an ongoing problem with depression since I was a teenager and landed up on Prozac for around 6 years and that stopped working and the withdrawal from that was extremely difficult…yet I had to go through that alone and it ended with me going to hospital! Worst experience of my life and the most scariest! I was put on Duloxetine as a result and have been on this for about 2 years …I started with 90mg which eventually helped and I felt like myself again but still I get that stupid twitching side effect, dry mouth etc! I went down to 60mg for a while and that was okay and thought I could do with going down to 30mg…which I managed to do but most days I feel so ill and my mind just doesn’t seem to function! I forgot things easily, it affects my speech – and I’m in a good job working in a good company but feeling this way can’t be my life! I went to the Drs and that didn’t help..I was told to go back to 90mg…she didn’t care and was prescribed more medication! I want to get rid of taking this drug as from experience withdrawals are a nightmare and this one seems to be the worst! Now if I carry on feeling sick, out of sorts, can’t function what are my options? Back to 60mg…? How long before I can feel normal again???? On 60mg I seem to feel a lot better but this isn’t the answer is it? I’m so easily confused and I need to be on top of the game at work otherwise I can forget about succeeding further! What can I supplement to help me through this? If not attempted no drug days as that would finish me! I’m stuck between a rock and a hard place! Feel depressed or feel somewhat normal with the meds knowing that eventually it’s not going to work anymore and then I’m up rubbish street again!

    • Debra
      Mississippi
      Reply

      Oh my God, I’ve been thinking that I was going insanely crazy, can hardly write, can’t think, so dizzy, thought about suiside at least 3 times, have cried uncontrollably, screamed awful hateful things at me husband, done nothing but move from couch to bed.. Was taken off Cymbalta one week ago. Thank God I found this site. Thank you for your story and helping me at least understand that it is side effects, and will fight through the effects, to rid myself of this horrible medication. AND be very careful in the future to KNOW everything about a drug before I take it.

  17. Katie
    Rowlett, TX
    Reply

    I have been on Cymbalta for the last 6 years for clinical depression that I have suffered for since I was diagnosed at age 16 and fibromyalgia at the age 32. I took Zoloft for years and was able to get off for a few years and then when my depression symptoms came back in my late 20’s my physician and counselor I had been going to for years suggested Cymbalta. To me it was a miracle drug!!! I am very diligent about staying up to date on my refills, however the few times I had to go 1 or 2 days without it….miserable, mood swings and full body pain. My issue now is I am 35 and want to start a family, but terrified to stop the medication and it is not an option to take if pregnant.

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