A bottle of generic delayed-release Duloxetine (Cymbalta) 30 mg

We have received so many complaints about duloxetine side effects that we have lost count. Far more disturbing are the number of people who tell us how hard it is to discontinue this drug.

Decades ago doctors might have told patients taking a drug like Cymbalta that if they experienced anxiety, irritability or strange sensations after stopping the drug, it was probably their underlying psychological problem returning. Now we know it is withdrawal from the medicine.

The History of Cymbalta:

Cymbalta was originally approved by the FDA in 2004 for the treatment of major depression. It is officially an SNRI-type antidepressant. In doctorspeak that means it is a serotonin-norepinehprine reuptake inhibitor and is somewhat similar to other antidepressants such as Effexor (venlafaxine) and Pristiq (desvenlafaxine).

The FDA also approved Cymbalta to treat nerve pain associated with diabetes in 2004. In 2007 the drug got a green light for anxiety and in 2008 the FDA agreed that it could ease the discomfort associated with fibromyalgia. It was also approved to treat musculoskeletal pain associated with arthritis and lower back pain in 2010.

In other words, here was a drug that could relieve your blues and your aches and pains. And the drug company that makes Cymbalta (Lilly) has been aggressively marketing it as a good way to deal with chronic low back pain and osteoarthritis. Perhaps you have seen the commercials on TV promoting the pain relieving power of the drug with the slogan “Cymbalta can help.” It sounds almost too good to be true.

Ah…and there is the rub. Although there is a long list of serious side effects mentioned during the commercial, the video images seem quite reassuring and trump the scary message the FDA requires for this medication. So, let’s set the record straight. Here, without visual interference, are a list of potential complications associated with this medication.

Cymbalta (Duloxetine) Side Effects

  • Nausea, stomach pain, constipation, diarrhea, decreased appetite, vomiting
  • Dry mouth
  • Insomnia, anxiety, tremor
  • Dizziness, fatigue, sleepiness
  • Sweating, hot flashes
  • Blurred vision
  • Headache
  • Sexual dysfunction, lowered libido, erection difficulties, lack of orgasm
  • Liver damage
  • Serious skin reactions, rash, hives (requires immediate MD assistance!)
  • Glaucoma
  • Irregular heart rhythms
  • Bleeding problems
  • Blood pressure problems
  • Interaction with other drugs (leading to serotonin syndrome among other reactions)
  • Pneumonia
  • Seizures
  • Depressed mood, suicidal thoughts and behavior, suicide

Such a long list of side effects makes your eyes glaze over after the top 3 or 4. That is why we have included stories from real people so you can better understand what these complications feel like.

Stopping Cymbalta:

Even though such side effects are scary, there is another problem with Cymbalta. When people try to stop taking this drug they frequently report unpleasant withdrawal symptoms. An organization (QuarterWatch) that monitors the FDA’s database of serious adverse drug events has noted that:

“We observed a signal for serious drug withdrawal symptoms associated with duloxetine (CYMBALTA), a widely used antidepressant that is also approved to treat arthritis and back pain, anxiety, and fibromyalgia. In the first quarter of 2012 the FDA received 48 case reports of drug withdrawal identifying duloxetine as the suspect drug. They described a wide spectrum of withdrawal effects that began when the patients stopped the drug, including blackouts, suicidal thoughts, tremor, and nausea. Several cases involved hospitalization.

Probing deeper into the scientific record for duloxetine we found that withdrawal symptoms were reported in 44-50% of patients abruptly discontinuing duloxetine at the end of clinical studies for depression, and more than half of this total did not resolve within a week or two. In addition, we identified a serious breakdown at both the FDA and the manufacturer, Eli Lilly and Company, in providing adequate warnings and instructions about how to manage this common adverse effect.”

Doctors have taken to calling this “discontinuation syndrome.” These clinical words do not do justice to what it is like to stop antidepressants like Cymbalta, Effexor (venlafaxine), Paxil (paroxetine), Pristiq (desvenlafaxine) or Zoloft (sertraline) suddenly.

Sudden Withdrawal Symptoms

  • Brain “Zaps” (electric shock-like senstations in the brain)
  • Dizziness, light-headedness, vertigo, feeling faint
  • Headaches
  • Anxiety, irritability, hostility
  • Nausea, diarrhea, digestive upset
  • Tremor, hands shaking, nerve tingles, strange sensations
  • Fatigue, tiredness, lack of energy
  • Visual disturbances

Again, a list of symptoms does not do this problem justice. Below you will read some stories from people who have posted their comments to this website. We would love to hear your story, positive or negative. Share your experience with Cymbalta or any other antidepressant below.

Should you wish to learn more about dealing with depression through some other strategies, we offer our Guide to Dealing with Depression. You will also find a whole chapter on prescribing mistakes doctors make when treating depression and fibromyalgia in our book, Top Screwups Doctors Make and How to Avoid Them.

Cymbalta Withdrawal Stories from Readers

– D.G. shares a tragic story:

“My lovely, young daughter-in law, who was about to celebrate her 29th birthday, was prescribed Cymbalta, Klonopin, and Ambien and has committed suicide.

“She told her physician and her therapist that she’d had thoughts of suicide but no one took her seriously. She suffered from depression, as well as an eating disorder, and had very low body weight. She also used alcohol.

“Please remind your readers of the potentially disastrous effects these chemicals can cause when taken carelessly or in combination with alcohol.”

This from – P.J.:

“I have been on Prozac over the last 20 years off and on and it finally stopped working. The last time I took it about 2 years ago I was taking the generic from Barr – the blue and white capsule. I was feeling as if I were in the deepest dark hole there ever was.

“My doctor put me on Cymbalta from which I had a lot of side effects such as palpitations, feeling constant dread, panic attacks, sweats, lightheadedness and general feeling of not being well.

“She added Abilify which put me over the edge. I was in the worst depression I have ever been in. Finally after living like this for several months, I asked to be put back on Prozac. I was taking the generic from Sandoz. When the prescription ran out I ended up on the big blue and white capsules from Barr.

“Over the last couple of weeks it has been constant crying spells, arguing with everyone and feeling pretty low. I talked to my doctor and she wrote the prescription for Sandoz only generic. The blue and white capsules are like taking a placebo. My doctor said she had had other patients who complained of the same thing and she had to write prescriptions for a certain generic or name brand.”

– R.P. says:

“I took Cymbalta for 3 days and thought I’d go nuts. I’m off it now and refuse to try any other drug like this. My main complaint was extreme hot flashes that estrogen wouldn’t help. I thought I’d be given Prozac, but was given Cymbalta instead. It was a rough 3 days and I stopped it last night. I am extremely tired yet cannot sleep at night. I think I was sweating even worse and my legs started feeling like I had Lyme disease again. And to be honest, within those 3 days of taking it, I didn’t contemplate suicide, but I had this crappy attitude of “who would care?”

– Nancy relates how hard it was to get off Cymbalta:

“It took me 18 months to get off Cymbalta, with no doctor’s help. I can hardly believe that doctors have no exit strategy for this dangerous drug. I had to find this out on my own from reading and as soon as I weaned off that – about a month, the tinnitus that had occurred decreased almost completely. No doctor told me this.”

— J.K. shares a parent perspective:

“My daughter experienced severe side effects when trying to come off Cymbalta – she had nausea, vomiting, lost peripheral vision for 24-48 hours, had shaking, etc. This was while she was doing a clinical in a hospital for college. Had she known she would have stayed on it until after clinical. I called the manufacturer and they acted like there were no such side effects from withdrawal.

“She too took apart the capsules and it took awhile, but finally she is free from that drug. I think it is a crime that the manufacturers don’t publish more detailed information concerning withdrawal. They could even make money selling a one month or two month step down prescription so individuals aren’t taking the capsules apart themselves.”

– P.C. Tells what it is like to switch around from one drug to another:

“I just turned 52 today. I went on a very low dose of Zoloft about 8 years ago to treat generalized anxiety disorder. It really did help for a long time. I recently have been pretty depressed (however I can cover it up really well) and my psychiatrist switched me to Effexor which was terrible for me. Now I’m trying Cymbalta which has not done anything either except make me feel more anxious and headachy and weird.”

“I am a registered nurse and I do not understand what the long term effects of these meds are and I am concerned. I really want to get off and see what I can do naturally for myself.”

– K.T. tells what it is like to try to stop Cymbalta:

“Getting off Cymbalta is challenging but not impossible. I, too, experienced the light-headedness, dizziness, and “brain zaps.” I described it as being able to “hear my eyes move.” It sounded like the light sabers on Star Wars. Very strange and disconcerting.

“The key is to do it very very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.

“Your doctor will probably be no help at all. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more. Be patient. I am completely off now and feeling GOOD.”

– Karen’s story:

“I was prescribed Cymbalta ‘off-label’ to manage fibromyalgia pain When I stopped taking it because it wasn’t delivering on the promised effect of reducing my pain, I became so horribly depressed that I required hospitalization as I had become SUICIDAL!

“I will NEVER take another anti-depressant for an off-label purpose….such as Elavil/amitriptyline as a “sleep aid” which is very commonly prescribed.

“I believe it should be criminal to prescribe ANY drug for a purpose other than the one it was approved to treat.”

– R.H. and Erectile Dysfunction:

“I’m a 76 year old man, my libido was very low. Taking Cymbalta for peripheral neuropathy added ED as a side affect of the drug. I had a testosterone blood test; it was 1/3 what the minimum should be. So I’m taking Androgel to raise testosterone levels and it is magic. I have great libido now and am working on minimizing the Cymbalta pills. In the meantime I have been prescribed Cialis for the ED. Each pill solves the sex problem for a couple of days.”

– M.O. on stopping Cymbalta:

“I have the exact symptoms as everyone else and it’s been a week. I only took Cymbalta for 2 months, but the side effects from stopping it are horrible. My doctor didn’t, nor did anyone else tell me, about any side effects and I did read the insert. Most of the time the listed side effects of meds don’t bother me, so I figured no problem.

“From reading other posts on this website and on other sites, the drug seems to affect every person the same way. I would never have taken it for my neck pain if I had known about the likelihood of side effects. The worst part for me is the dizziness, the brain zings and the sudden burst of tears for no reason. I would never take this drug again. I think the FDA needs to do longer studies on all drugs and be honest with their findings and that doctors should be honest and tell their patients what really happens when you take Cymbalta.”

Please add your own experience below in the comment section.

Revised 1/28/16

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  1. Teresa

    Have taken Duloxitine for a year for fibro. Started on 30 mg. Didn’t think it was helping so Dr put me 60 mg. I slept well but had awful nightmares. Then seemed to stop working. Fibro symtoms worse, weight gain, couldn’t sleep. Fatigue. Read about side effects. Told Dr. wanted to stop taking it. Gave me a script for two weeks worth of 30 mg. That was the extent of tapering. Have developed gaze-tinnitus and joint pain and fatigue is worse. Will never take chemicals again.

  2. Lisa

    I am 49 and have been on anti’s for about 15 years. I started experiencing some aches and pains around age 43 and my doc out me on Cymbalta. The drug seemed to take care of the aches and minor depression in one.

    I have been on it since and recently lost my script on a trip. After 2 days I started feeling the effects. I decided after being off of it for five days that the ill feelings I was having would be over in another week so I thought I would give my body and mind a detox and see how I would feel. After two weeks, I actually started to think I had a brain tumor or I was due for a stroke or heart attack.

    Tonight I got brave enough to Google the effects of getting off of this drug. I must say my reading has been bitter sweet. So thankful I prob don’t have a brain tumor but also discouraged at just how long these bad physical feelings might last. I think I’m going to start drinking a lot of water and popping Vit C several times a day to speed this detox up! Good luck to those of you going through this.

  3. Bonnie

    I’ve got dysthymia and fibro or might all be fibro. No problem taking Paxil or getting off of it. No meds for about 7 years. Depression got really bad and tried Cymbalta because hoped it would help with pain. It’s helped tremendously! More for pain than depression. So after 3 years I’ve stopped a week ago. Was going well. Today extreme joint pain. Will see if my arsenal of holistic remedies help. Remembering why I used to live on ibuprofen before Cymbalta. Not sure if this is withdrawal or returning to baseline.

  4. Kristen
    Austin, Texas

    I was on Cymbalta for approximately one year when my previous anti-depressant stopped working. On March 6, 2016 I stopped cold-turkey due to getting sick and not being able to swallow the medication for several days. My husband and I thought I might be pregnant, so getting back on Cymbalta to wean off was not even an option for me. I went into withdrawal and have been dealing with severe nausea, headaches, insomnia, occasional brain zaps, uncontrollable chills, and emotional instability. I think I am at day 47 now.

    I did not realize how many adverse side effects I had while taking Cymbalta because I attributed the vast majority of them to another medication I was taking for nerve pain and severe headaches. While on Cymbalta my resting heart rate was between 115 and 120 bpm. I gained 40 pounds despite eating a reduced calorie diet; I was so confused and hopeless. I felt I could not work out because it would send my heart rate soaring and I’d become dizzy and breakout in a sweat and have to lay down. This would happen when I would try to do some thing simple like make the bed or put on makeup and do my hair. Simple stuff, right? Ugh… I had horrific dry mouth, restless leg syndrome, heart palpitations, high blood pressure, vertigo, tinnitus. I no longer enjoyed life and knew death was at my doorstep. And I’m only 37.

    Had I not gotten sick on March 6, 2016 I would not be where I am today. Despite withdrawal, I have never been more hopeful in my life. I work closely with my psychotherapist, psychiatrist, primary care physician, in addition to a personal trainer to help me shed the body fat that is holding onto the Cymbalta, and an amazing woman who helps me safely detox using sea clay wraps and steam. I also attribute my success to those who have shared there experiences with this awful drug on the numerous forums I find in the middle of the night when I cannot sleep. It helps to know I’m not alone and more importantly that I’m not crazy.

  5. Betty

    I was given Cymbalta when I felt Lexapro (all generics) was not controlling my anxiety. I was to wean off Lexapro as I increased Cymbalta. I lasted two weeks when I called back the prescribing PA and the pharmacist asking about the side effects I was having. The worst being increased anxiety, panic attacks, loss of appetite, and terrible diarrhea. I couldn’t be far from a bathroom.

    They were surprised and said they hadn’t heard that. On my own, I immediately began to reverse what I had done, weaning off the Cymbalta and increasing back to the Lexapro. The ONLY thing that gave me some peace of mind was the testimonies about this drug. I am on my 4th day without Cymbalta, still depressed, anxious, and have diarrhea.

    I have since started going to a Naturalpath Dr. The response from his office when I told him no one wanted to blame the Cymbalta was, “do they live under a rock”? I’m looking forward to the days ahead when I find myself again, and I don’t feel like hiding under a rock. Not only is this humiliating, but embarrassing to explain my withdrawal from my normal activities.

  6. Susan

    I’ve been taking 60mg Cymbalta 1Xdaily for 8 years to treat fibromyalgia, hot flashes and interstitial cystitis pain. After talking to my sister about her failed trials to stop taking the drug, I tried to wean off it by taking it every other day. Thing went well for the first week but I then started sweating, began feeling nauseated, had dizziness, vomiting and severe diarrhea with bleeding.
    I went back on the drug because I couldn’t miss any more days at work.
    The doctors withdrawal plan was similar to the above, so I will try taking the capsules apart and slowly increase the number of tiny balls I remove over a 6 wk period.

  7. Karen

    I was on Cymbalta for chronic pain, depression and anxiety for about a year. What a big mistake. My mind was totally off, and I didn’t feel like me. I was agitated, had suicidal thoughts, and rage. Once I read about this drug and dug a little deeper, I realized it was the Cymbalta. That’s when I called my doc to wean me off.

    It’s been since January that I have been on this path to hell (withdrawal). First it was the nausea, sweats, insomnia (I haven’t slept well since I went off this garbage). I feel like a walking zombie most days, afraid to drive from lack of sleep. The brain zaps are frequent throughout the day(10+), and my upper body from my chest up, feels an odd sensation, and for some reason am getting frequent chilling sensations, like I have the flu With the few nights I got to sleep I would wake up with severe anxiety, like a brick was on my chest. Luckily, I self-talked myself out of it and realized it was from the drug, redirected myself to something productive, and it passed. My doc gave me the 2 week plan to wean myself off of this nasty drug.

    After following her two-week protocol, I realized she didn’t know about the withdrawal symptoms. So as I said, I looked online for answers. I created my own schedule to wean based on the numerous online posts. I did one (30 mg.) every other day for 3 weeks, then down to 2 pills every 4th day for three weeks and that’s where the side effects really kicked in. After that I needed a refill, got the refill and said that’s it I am done. As of today, the most important benefit of getting off this drug is that my mind is clear, suicidal thinking is non-existent, agitation gone, rage gone. My brain feels different in a positive way, and my verbal “filter” is back. It’s weird but I feel I have control, except for the side effects, of course.

    Doc wanted to put me on Gabapentin for sleep and pain. Another winner full of side effects, withdrawal issues, and rapid weight gain among a handful. No way. The only advice I can give others is: please read the package insert or do an online search on the risks and benefits of each drug you need to take. Don’t blindly follow your doctor, I didn’t know about the risks of withdrawal and it was never communicated. Be your own advocate.

  8. colette
    Nova Scotia

    Hi, I have been taking cymbalta for almost 5 years due to chronic back pain. I have stopped taking the medication not by choice just waiting for my Dr to return. It has been day four without them and I am starting to feel the aweful scary affects. I I had of known this medication was so difficult to stop I would have much rather suffered with the pain.

  9. Shirley
    Los Angeles

    I only took the drug for approximately 6 weeks. I’ve lived with fibromyalgia for about 20 years, and although the pain can be debilitating at times, I try all options for alternative medicine, exercise religiously, and limit my bad eating to a few times a month.

    My biggest issue has been the inability to sleep, so for about 10 years I’ve switched from Ambien to Lunesta. It concerned me that I had been on these drugs for so long, so I went to the doctor to try talk about alternatives, I was prescribed Cymbalta and Lyrica, but none of the drugs helped me sleep. So I decided that adding two more medicines was not the best idea.

    I am working on getting off of them, and the side effects are awful. I feel like my brain is shaking in my head. I feel off-balance when I stand up suddenly, and I am constantly feeling like I’m on the down-turn on a roller coaster. I hope this is the worst of it.

  10. Judy

    I have been on Cymbalta for over 5 years. I didn’t think it worked until I had to stop taking it abruptly until my new RX plan covered it. I am so physically ill I cannot function. The nausea is unbearable. I am constipated, I have a bladder infection. My head is spinning. All of my joints ache and my fibromyalgia is the worst I can remember. I want to bite off heads, so tired yet I cannot sleep. I will never be without it again. And everything makes me cry. I am 64 years old and I am ready to die. Thank goodness the pharmacy is shipping it out as soon as possible. To me it is the one medication I have to take.

  11. Julia

    I have learnt a hard and painful lesson, I didn’t realise my repeat prescription for Cymbalta has run out, I missed 2 doses before I got into any GP to get a script. I have never felt so awful and ‘wrong’…….dizziness, feeling like I may faint, strange sensation in my head…..well described as ‘brain zaps’ by others, and feeling like I may vomit. I plan to wean myself off it, if this is how mt body responded after 2 days without it I dont want it……scary stuff.

  12. John

    I have been off Duloxetine for the last two days when my script ran out and was feeling quite lightheaded and borderline dizzy this morning when I woke up. I am going to be calling in for my third refill. I have been taking a half dose for 2-3 months now. My PCP backed me down to a half dose after taking a full dose resulted in feeling totally spaced out and tired all day to the point I really couldn’t function well at work. It’s hard for me to notice any prominent benefits of this drug, but the withdrawals are certainly noticeable from my brief 3 month experience. I’d love to read more on the physiology of how this drug actually interacts with my body. I’m going to try to do a nine month round of it according to my doctor’s plan, but I am on the fence so far simply because I did not want to take a drug that reacted like this where I couldn’t get off of it easily. It’s certainly not an addictive drug but the side effects are real. It is quite a funky feeling even after just 2 days off, and I certainly did not want that effect when taking a drug to help cope with depression. Ashland City

  13. Brenda
    Euless, TX

    I must be one of the fortunate ones. I have been on Duloxetine for a year now with no side affects or problems. It has helped me tremendously.

  14. judy
    beverly oh

    i was put on dulexitine for nerve pain tingling numbness in feet took them for while till i started first not being able to rember things dierra voiting crying couldn,t get out of bed called dr she said stop medicine call her in 2 weeks systoms were getting worse fellt like there was no hope dr finally called me in to check my medicine which she did not talk about effects of medicine she just wanted to change my ampotripoline to higher mg just avoided all questions about duloxitine whic i found out was cynbalta still sick but wont take tht medicine anymore

  15. valinha

    For nearly 7 years I have been taking 60mg Cymbalta. Side effects are terrible. I have tried to quit at once for 3 times and have not been able.
    I’ve been slowly lowering the dose for 3 months and now I’m taking 10mg and almost did not get withdrawal symptoms.

    During the 7 years of consumption of this drug I have suffered from nausea, vomiting, indigestion, diarrhea, constipation (which took me to the hospital with an intestinal obstruction subjected), fluid retention, weight gain (20 kg), fatigue, insomnia, lack of empathy, depression, anxiety, mood swings, aggressiveness, lack of interest, lack of ambition, my libido has disappeared (I have come to feel disgusted by any physical contact), lack of concentration, memory failures short term…

    I have come to feel grateful to be out of work in recent years, because I believe that it would be impossible to keep a job in this way.

    My husband is a wonderful person who bears the situation as best he can. My daughter barely knows me otherwise, is 10, and do not even know how to explain that her mother was not this human waste that now she sees.

    I must admit that some of these symptoms are still prevalent, but most of them have been disappearing with the gradual reduction of the drug.
    The times I’ve tried to quit abruptly have not been able to resist the withdrawal symptoms that seemed that instead of decreasing, were increasing day after day

    • sandi
      Decatur, IL.

      I have been on 90 mg. for years. My Dr. only faxed 60 mg. to the pharm. and I thought oh well I less pill to take. Boy was I wrong. After a few days my legs turned to jello, I couldn’t walk, my fingers bounced up and down on the key board and the brain zaps were awful. It doesn’t do anything for my depression or my severe arthritis. I want off of it but I am scared.

  16. Steve
    Kuna Idaho

    I was put on cymbalta by doctor after suffering a spontaneous brain bleed for depression, nine months latter I decided to wean off cymbalta by taking every other day due to I’m taking Wellbutrin also . I ended up in ER last night due to the brain zaps they did a CT scan, blood work and a spinal tap to find what’s causing the brain zaps of electricity and headaches with no resolve, came home in pain zaps still there and finally fail asleep, woke up at 2am and was thinking maybe there is side effects of not taking cymbalta, sure enough there is. I feel better knowing what’s causing brain and eye zaps of electricity but at same time how long will I have them.

  17. Karol
    St Louis Missouri

    I have been taking Cymbalta for over 10 years with minimal side effects. I lost my insurance one month ago and was unable to fill prescription 2 weeks later. First week post Cymbalta wasn’t too bad. Then it started, some time Sunday, mild brain zaps, dizziness and pain. By Monday I couldn’t get out of bed. Any movement caused continual zaps and dizziness, the pain was ongoing and increasing in intensity. Tuesday the tremors started, hot flashes, chills and severe mood swings. Tuesday night I went to bed in tears, exhausted from this withdrawl. Its late Wednesday now, I have spent the day researching options to cope with this, not finding any answers. I have never used recreational drugs but am considering thc edibles, no idea if it will help but I am desperate to get relief, I can’t live like this. The tremors are so bad right now it is taking forever to type this. I need help, I need answers.

  18. Mary
    Whitinsville MA

    I started taking Cymbalta shortly after my husband passed away. When I reached three a day I noticed it was a co-pay of $50. and asked my physician if there was anything else I could take. She told me I should stay on it because there wasn’t anything comparable for my symptoms. About a year ago I dropped my pills to two and six months later one. I noticed the tremors and many of the other withdrawal symptoms but attributed them to age fibromyalgia and arthritis. The last pill put my symptoms over the top. I cry about everything, scream about everything and am a miserable human being. Right now I’m being tested for diverticulitis but wonder if the flu symptoms and pain could be withdrawal. I’m so sick of being sick !!!

  19. Sharon

    I was prescribed Duloxetine for serious anxiety & for serious crippling pain caused by Fibromyalgia & serious crippling pain caused by Osteoarthritis.

    I am a very very intelligent lady.

    I had been on my Sertraline for 10 years & it did nothing at all for me.

    I have been on Duloxetine for 4 weeks now & I can’t stop crying I feel so alone & I feel like I’m in a very deep black hole that I can’t get out of.

    I have an emergency appointment on Monday to tell the nurse I will no longer need Duloxetine she can keep them!

    I’ve experienced every side effect that this drug has & to me that tells me the bad well out weighs the good.
    I’ve been so anxious.
    I’ve had trouble sleeping.
    I sweat like crazy.
    I have muscle spasms.

    And I’ve had suicidal tendencies where on Thursday night I laid my dosette on my bed & I told a helpline that I thought if I took them all I wouldn’t be in serious crippling pain any more.

    Plus I wouldn’t feel so anxious & I wouldn’t be crying all the time.

  20. Laura

    I was on 60mg of cymbalta for 4 years of which I suffered horrid diareah continually when the gastro could not figure out what was causing it I done my own research to find cymbalta could be the cause. I was originally put on it for mild depression and fibromyalgia then was diagnosed with multiple sclerosis. I decided to wean myself by way of taking the capsules apart o done this over a 6 week spand was the worse six weeks of my life was not sure who the person I was racing thoughts brain zaps palpitations no sleep ect… But the diareah slowly subsided I am free from cymbalta 4 months and suffer horrid cognitive, memory problems to the point where I can’t work full time cause I become what I call special in the head within about 5 hours into my day and I suffer from not having even the thought process to even tell myself to eat. Not sure if this is gonna be life post cymbalta what I can say is this didn’t happen until weapon off of. I feel as tho cymbalta has taken pretty much my life as I knew it away and replaced it with a living hell for not just myself but my family as well 😩 It’s a drug that definitely needs to be banned period it’s destroying people’s lives I now only take 10 mg of elavil at nite to sleep and it’s been very successful and I can say I can go days without taking the elavil and have no side effects from not taking it are there any current law suits that people can sign up for that are against the manufacturer of cymbalta I want on board if for nothing else but to be part of making a statement as a patient that’s life has been forever changed

  21. Donna
    South Carolina

    I was on 60 mg. For 4 months. It was added to another medication with the hope of controlling chronic migraines. No luck. Terrible side effects–weight loss, fatigue, metallic taste, to name a few.

    I decided on my own that I wanted to stop the medication. The doctor recommended that i cut back to 30 mg for 1 week, then stop taking it completely. I haven’t taken it for 3 days and I am sicker today than I was yesterday–so sick I couldn’t even get out of bed. Dizziness, nausea, brain zaps, uncontrollable crying. My eyes feel so weird–my peripheral vision seems off.

    I am waiting for a call back from my neurologist. I am wondering if I should tough it out and not take any cymbalta, or if I should break open a capsule and take 15 mg. For a week or so, then get off. Any suggestions?

    • Terry Graedon

      Donna, we hope you got through this and heard from your doctor.

    • valinha

      For nearly 7 years I have been taking Cymbalta. Side effects are terrible. I have tried to quit at once for 3 times and have not been able. I’ve slowly lowering the dose for 3 months and now I’m taking 10mg and almost did not have withrawall symptoms

  22. Anna

    I switched to cymbalta for about a little over a month (30mg for 15 days, 60mg for 10 days and another week back to 30 days). The back pain disappeared once at 60mg, my mood was better, more stable and less anxious, but I had terrible stomach pain, night sweats, insomnia, feeling very tired and lethargic. I was also starting to feel more depressed so I ended up stopping and it has been 2 weeks so far. The withdrawals are just plain horrible. Day and night sweats, vivid dreams, feeling dizzy all the time and weak like my blood sugar was always low (but I know its ok its just an overall feeling), and the worst are these brains zaps as if I had my fingers in an electrical plug 24/7, also feeling as if my brain is floating in my head and every noise makes it move around. I am also having a very hard time to concentrate or focus. After a week off these meds I started being very irritable and angry quickly, or I cry easily. From what I read it could last 4 weeks – if I am lucky!!! What a strong and terrible drug. There should be 1 to 5-10-15mg available to help with the withdrawals! Or not be prescribed ever.

  23. Michael
    Hitchin UK

    I have been suffering from AMD for two years now. My eye Consultantn injected me with with Lucentis. From that moment I started to feel dizzy. As I had medical insurance I mentioned to the eye Consultant each time I saw him that I thought the problem was due to Lucentis. each time he dismissed this. During the last two years I saw six different consultants and on each occasion they dismissed out of hand the possibility that Lucentis was the cause.

    Finally I was prescribed 30mg Dulexetine. The side effects were awful. I wrote to the Consultant saying that I was stopping these tablets forthwith. He replied that I must take these tablets for a period and things will improve. After three months I was no better so I did some research on Lucentis. One of the side effects was headaches and giddiness. When I presented these documents to the Consultant he just said we will use Eylea. He should have changed this drug to Eylea when I first started to complain.
    It appears hospitals are not telling people about this side effect with Lucentis. One nurse tried to cover up by saying it’s better to have headaches and giddiness than having poor sight in one eye.

    My GP carefully worked out a plan to stop Dulexetine. A week after finally stopping Dulexetine I had an awful reaction. I am now living with constant headaches and dizziness. What annoys me is the fact that this drug is given for depression and suicidal thoughts. I do not suffer from these symptoms. Although Eylea injections seem to work My general health has been ruined by Dulexetine. With all the side effects it produces Elli Lilley the drug manufacturer should be banned from marketing this drug in the UK

  24. Helga
    Houston, TX

    I have been on Cymbalta for about 2-3 months and have NEVER felt not one tenth of the symptoms I am feeling from this crappy medication. I recommend that you remove this OFF the market because it causes more harm than good based on how I feel and the reviews I have read here. The nausea and dizziness is UNBELIEVABLE!!!!!!!!! I have been off it for one week and am wondering how long it takes to be completely back to normal? I will tell everyone I know and my doctor to not take this medication nor prescribe it to anyone.

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