A bottle of generic delayed-release Duloxetine (Cymbalta) 30 mg

Cymbalta was originally approved by the FDA in 2004 for the treatment of major depression. It is officially an SNRI-type antidepressant. In doctorspeak that means it is a serotonin-norepinehprine reuptake inhibitor and is somewhat similar to other antidepressants such as Effexor (venlafaxine) and Pristiq (desvenlafaxine).

The FDA also approved Cymbalta to treat nerve pain associated with diabetes in 2004. In 2007 the drug got a green light for anxiety and in 2008 the FDA agreed that it could ease the discomfort associated with fibromyalgia. It was also approved to treat musculoskeletal pain associated with arthritis and lower back pain in 2010. In other words, here was a drug that could relieve your blues and your aches and pains. And the drug company that makes Cymbalta (Lilly) has been aggressively marketing it as a good way to deal with chronic low back pain and osteoarthritis. Perhaps you have seen the commercials on TV promoting the pain relieving power of the drug with the slogan “Cymbalta can help.” It sounds almost too good to be true.

Ah…and there is the rub. Although there is a long list of serious side effects mentioned during the commercial, the video images seem quite reassuring and trump the scary message the FDA requires for this medication. So, let’s set the record straight. Here, without visual interference, are a list of potential complications associated with this medication.

Cymbalta (Duloxetine) Side Effects

  • Nausea, stomach pain, constipation, diarrhea, decreased appetite, vomiting
  • Dry mouth
  • Insomnia, anxiety, tremor
  • Dizziness, fatigue, sleepiness
  • Sweating, hot flashes
  • Blurred vision
  • Headache
  • Sexual dysfunction, lowered libido, erection difficulties, lack of orgasm
  • Liver damage
  • Serious skin reactions, rash, hives (requires immediate MD assistance!)
  • Glaucoma
  • Irregular heart rhythms
  • Bleeding problems
  • Blood pressure problems
  • Interaction with other drugs (leading to serotonin syndrome among other reactions)
  • Pneumonia
  • Seizures
  • Depressed mood, suicidal thoughts and behavior, suicide

Such a long list of side effects makes your eyes glaze over after the top 3 or 4. That is why we have included stories from real people so you can better understand what these complications feel like.

Even though such side effects are scary, there is another problem with Cymbalta. When people try to stop taking this drug they frequently report unpleasant withdrawal symptoms. An organization (QuarterWatch) that monitors the FDA’s database of serious adverse drug events has noted that:

“We observed a signal for serious drug withdrawal symptoms associated with duloxetine (CYMBALTA), a widely used antidepressant that is also approved to treat arthritis and back pain, anxiety, and fibromyalgia. In the first quarter of 2012 the FDA received 48 case reports of drug withdrawal identifying duloxetine as the suspect drug. They described a wide spectrum of withdrawal effects that began when the patients stopped the drug, including blackouts, suicidal thoughts, tremor, and nausea. Several cases involved hospitalization.

Probing deeper into the scientific record for duloxetine we found that withdrawal symptoms were reported in 44-50% of patients abruptly discontinuing duloxetine at the end of clinical studies for depression, and more than half of this total did not resolve within a week or two. In addition, we identified a serious breakdown at both the FDA and the manufacturer, Eli Lilly and Company, in providing adequate warnings and instructions about how to manage this common adverse effect.”

Doctors have taken to calling this “discontinuation syndrome.” These clinical words do not do justice to what it is like to stop antidepressants like Cymbalta, Effexor (venlafaxine), Paxil (paroxetine), Pristiq (desvenlafaxine) or Zoloft (sertraline) suddenly.

Sudden Withdrawal Symptoms

  • Brain “Zaps” (electric shock-like senstations in the brain)
  • Dizziness, light-headedness, vertigo, feeling faint
  • Headaches
  • Anxiety, irritability, hostility
  • Nausea, diarrhea, digestive upset
  • Tremor, hands shaking, nerve tingles, strange sensations
  • Fatigue, tiredness, lack of energy
  • Visual disturbances

Again, a list of symptoms does not do this problem justice. Below you will read some stories from people who have posted their comments to this website. We would love to hear your story, positive or negative. Share your experience with Cymbalta or any other antidepressant below.

Should you wish to learn more about dealing with depression through some other strategies, we offer our Guide to Dealing with Depression. You will also find a whole chapter on prescribing mistakes doctors make when treating depression and fibromyalgia in our book, Top Screwups Doctors Make and How to Avoid Them.

Cymbalta Withdrawal Stories from Readers

“My lovely, young daughter-in law, who was about to celebrate her 29th birthday, was prescribed Cymbalta, Klonopin, and Ambien and has committed suicide.

“She told her physician and her therapist that she’d had thoughts of suicide but no one took her seriously. She suffered from depression, as well as an eating disorder, and had very low body weight. She also used alcohol.

“Please remind your readers of the potentially disastrous effects these chemicals can cause when taken carelessly or in combination with alcohol.”
– D.G.

“I have been on Prozac over the last 20 years off and on and it finally stopped working. The last time I took it about 2 years ago I was taking the generic from Barr – the blue and white capsule. I was feeling as if I were in the deepest dark hole there ever was.

“My doctor put me on Cymbalta from which I had a lot of side effects such as palpitations, feeling constant dread, panic attacks, sweats, lightheadedness and general feeling of not being well.

“She added Abilify which put me over the edge. I was in the worst depression I have ever been in. Finally after living like this for several months, I asked to be put back on Prozac. I was taking the generic from Sandoz. When the prescription ran out I ended up on the big blue and white capsules from Barr.

“Over the last couple of weeks it has been constant crying spells, arguing with everyone and feeling pretty low. I talked to my doctor and she wrote the prescription for Sandoz only generic. The blue and white capsules are like taking a placebo. My doctor said she had had other patients who complained of the same thing and she had to write prescriptions for a certain generic or name brand.”

– P.J.

“I took Cymbalta for 3 days and thought I’d go nuts. I’m off it now and refuse to try any other drug like this. My main complaint was extreme hot flashes that estrogen wouldn’t help. I thought I’d be given Prozac, but was given Cymbalta instead. It was a rough 3 days and I stopped it last night. I am extremely tired yet cannot sleep at night. I think I was sweating even worse and my legs started feeling like I had Lyme disease again. And to be honest, within those 3 days of taking it, I didn’t contemplate suicide, but I had this crappy attitude of “who would care?”

– R.P.

“It took me 18 months to get off Cymbalta, with no doctor’s help. I can hardly believe that doctors have no exit strategy for this dangerous drug. I had to find this out on my own from reading and as soon as I weaned off that – about a month, the tinnitus that had occurred decreased almost completely. No doctor told me this.”
– Nancy

“My daughter experienced severe side effects when trying to come off Cymbalta – she had nausea, vomiting, lost peripheral vision for 24-48 hours, had shaking, etc. This was while she was doing a clinical in a hospital for college. Had she known she would have stayed on it until after clinical. I called the manufacturer and they acted like there were no such side effects from withdrawal.

“She too took apart the capsules and it took awhile, but finally she is free from that drug. I think it is a crime that the manufacturers don’t publish more detailed information concerning withdrawal. They could even make money selling a one month or two month step down prescription so individuals aren’t taking the capsules apart themselves.”
– J.K.

“I just turned 52 today. I went on a very low dose of Zoloft about 8 years ago to treat generalized anxiety disorder. It really did help for a long time. I recently have been pretty depressed (however I can cover it up really well) and my psychiatrist switched me to Effexor which was terrible for me. Now I’m trying Cymbalta which has not done anything either except make me feel more anxious and headachy and weird.”

“I am a registered nurse and I do not understand what the long term effects of these meds are and I am concerned. I really want to get off and see what I can do naturally for myself.”
– P.C.

“Getting off Cymbalta is challenging but not impossible. I, too, experienced the light-headedness, dizziness, and “brain zaps.” I described it as being able to “hear my eyes move.” It sounded like the light sabers on Star Wars. Very strange and disconcerting.

“The key is to do it very very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.

“Your doctor will probably be no help at all. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more. Be patient. I am completely off now and feeling GOOD.”
– K.T.

“I took Cymbalta for fibromyalgia and have just stopped taking it because of acute liver and GI pain- yes, pain! My liver poured bile into my gut and protested loudly! Cymbalta worked great on the fibromyalgia, but I had to stop.

“I agree that doctors don’t always realize how prescription drugs can alter your life so we must continue to advocate for ourselves.”
– V.C.

“I was prescribed Cymbalta ‘off-label’ to manage fibromyalgia pain When I stopped taking it because it wasn’t delivering on the promised effect of reducing my pain, I became so horribly depressed that I required hospitalization as I had become SUICIDAL!

“I will NEVER take another anti-depressant for an off-label purpose….such as Elavil/amitriptyline as a “sleep aid” which is very commonly prescribed.

“I believe it should be criminal to prescribe ANY drug for a purpose other than the one it was approved to treat.”
– Karen

“I’m a 76 year old man, my libido was very low. Taking Cymbalta for peripheral neuropathy added ED as a side affect of the drug. I had a testosterone blood test; it was 1/3 what the minimum should be. So I’m taking Androgel to raise testosterone levels and it is magic. I have great libido now and am working on minimizing the Cymbalta pills. In the meantime I have been prescribed Cialis for the ED. Each pill solves the sex problem for a couple of days.”
– R.H.

“I have the exact symptoms as everyone else and it’s been a week. I only took Cymbalta for 2 months, but the side effects from stopping it are horrible. My doctor didn’t, nor did anyone else tell me, about any side effects and I did read the insert. Most of the time the listed side effects of meds don’t bother me, so I figured no problem.

“From reading other posts on this website and on other sites, the drug seems to affect every person the same way. I would never have taken it for my neck pain if I had known about the likelihood of side effects. The worst part for me is the dizziness, the brain zings and the sudden burst of tears for no reason. I would never take this drug again. I think the FDA needs to do longer studies on all drugs and be honest with their findings and that doctors should be honest and tell their patients what really happens when you take Cymbalta.”
– M.O.

Please add your own experience below in the comment section.

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  1. BF
    Austin, TX
    Reply

    I took Cymbalta 7 months for lower back pain. The highest dose was 160mg 2/day. I went through most of the normal side effects while I was taking the medication. I also experienced sleepwalking, inability to remember my dreams, memory lapses, muscle spasms when I lay down, and incontinence.

    Since the medication didn’t improve the pain I decided to discontinue Cymbalta. I used the recommend titrate method to discontinue. During the titrate time span I experienced even more withdrawal symptoms. One of the worst was the brain “zaps”, it felt like there was a fly stuck in my brain buzzing trying to get out. My dreams have come back unfortunately they are very vivid nightmares. I hadn’t had a nightmare since I was a child. The only thing I can say is being on Cymbalta is a horrible experience. There has to be a better way to get rid of back pain. I wish everyone the best of luck during their experience.

  2. Lisa
    Canada
    Reply

    I tried this medication for three days. It was horrible. Like others have said I thought I was loosing my mind. I went back on my original anti-depressant. My daughter is on it, she also had a seizure shortly after starting this drug, Now I wonder if they could be related as know one can determine why she had the seizure, The seizure that caused her accident and changed her life completely. I have tried to get her doctor to change the medication but the doctor does not want to do that. Now I have a lot of questions and not a lot of answers. This is a wicked drug. LL

  3. shane
    Kearney ne
    Reply

    I’ve been on cymbalta for 2 years my inc needed a pre-approval for it now for some reason I’ve only been off it for 3 days and the withdrawals are horrid. I feel really funny and dizzy. But for the most part it has really helped me.

  4. Stephanie
    Tallahassee
    Reply

    Wow…. who knew. I had knee replacement surgery in December and forgot to get my Cymbalta refilled. A few days later I felt like I had a sleeping disorder. If I stopped moving I fell asleep, I had no energy and overall felt like crud! Then a friend went through the list of meds and that is when I realized I had not refilled my Cymbalta. Started back and was fine. Now after reading this I am wishing I had not! I am taking Cymbalta for nerve pain in the feet…want to come off of it because it’s not doing any good. Guessing I better hold on for the ride and pre-warn everyone around me and apologize ahead of time.

  5. JB
    TX
    Reply

    I am glad I had a bad experience with Cymbalta the first time I took it. They gave to me for arthritis and lower back pain. I was feeling like I had the flu. Body aches, lethargic, muscle cramps, nausea, to name a few. Do not like this at all. I called Dr. and nurse responded by offering to lower dose, I said no thanks, and asked if I should go to emergency or to Dr. and she said just normal side effects. Hmmmm, glad I didn’t take this long after reading all the comments with withdrawal and other issues.

  6. H L
    Los Angeles
    Reply

    I took 60mg of Cymbalta for back/sciatic pain for the past 4 years or so. It never did help with the back pain, but it did help with rage/anger issues and also with obsessive food issues, so I was fine with taking it, as I felt that I did have a benefit. However, that benefit has diminished to the point where I am now trying to get off of the drug. I went down to 30mg with no side effects, but in dropping down to 20 mg, I seem to have most of the ones listed – hot flashes, bursting into tears at news stories, dizziness, upset stomach, etc. My thought was that if I was going to have these side effects from the 20mg dose, I might was well just stop taking the effing stuff. So, I’ve not taken any for the past 2 days. After reading the comments here, I’m unsure of how to proceed. I just want to get this crap out of my system. Any thoughts? How long do the cessation side effects last – on average? Thanks.

  7. Jacky
    United States
    Reply

    I have been on Cymbalta for 5 years. I began with the name brand and then was required by my prescription insurance two years ago to switch to generic form. My first two weeks taking the drug were extremely unsettling. It was prescribed for my depression, anxiety poor self image. I was confused and anxiety level was very high. I had difficulty with relationships with family and coworkers. My dose was increased and that seemed to decrease my anxiety and poor self image. Since take the drug I have very low sex drive. This has had adverse effect on my marriage. I have difficulty achieving orgasium and don’t like to be touched sexsually. I continue to have problems with relationships. I do not dream at all and feel as though my whole body is desensitized from environmental stimulation. I take risks such as speeding and drinking and driving that put me in dangerous situations. I have short term memory loss and transpose number and letters when I write od read them. My doctor has asked when I plan to go off the drug but I am very leery to go off it. I recently moved from the Midwest to a tropical environment. Having more sunshine has helped me greatly. I will eventually go off the drug but don’t know when. I really miss enjoying sex and dreaming.

  8. Tabitha
    WV
    Reply

    Long story short: I started taking Cymbalta in December for fatigue & fibromyalgia. After looking up the side effects last week & noting that I was experiencing quite a few (multiple severe headaches [almost daily], fatigue, sweating, & severe dry mouth) I decided to quit taking it. 2 days after doing thus I started having SEVERE dizziness, sweating, more headaches, & feeling like the world was constantly spinning out of control (vertigo/fainting feeling). This does decrease majorly after being in a relaxed position for a few minutes but increases drastically as soon as I move or stand up. DO NOT STOP TAKING THIS MEDICINE WITHOUT A DOCTOR’S CONSULTATION!!! I feel like I’m going crazy because the world is constantly spinning out of control. I don’t know how long these withdrawal symptoms will last but I pray they will end soon!!!

    • stephanie
      il
      Reply

      Please keep me updated, as I feel the same way. I was on this med for a month I hated it, affected my irregular heart beat. Now I stopped taking it cold turkey 3 days ago and started zoloft. Feeling dizzy, sick to stomach, and feel hung over like my eyes can’t keep up my head. Ugh my Dr. felt I didn’t need to wean off cause of my heart. She told me to hang on. I asked how people with full time jobs can do this? I am going for a message tomorrow. I have faith in God and pray each day gets better. Xanax helps also. She told me 5-7 days.

  9. Helen
    Reply

    Let me add an addendum to my previous post. I want to continue cymbalta. It works for me. However, being forced to stop it abruptly has really caused some intense side effects. I don’t know about anyone else but I take 90 mg qd, which is a pretty hefty dose.

  10. Helen
    Buda, tx
    Reply

    I’ve been on cymbalta for, oh I think about 2 years. It has been a life saver for me as I attempted suicide twice and spent 4 days on life support before starting cymbalta. However, my spouse and I went to our lake house for a couple of days and lost a piece luggage that had his HTN meds and my cymbalta in it. I notified my psychiatrist’ front office and was assured that the issue would be addressed. It has been 5 days now and my face is as red as a cardinal, I’m irritable, weepy, and have GI problems, visual blurriness and intractable insomnia. I ache all over. Believe me I will address this with my physician.

  11. David
    Australia
    Reply

    When I first started on Cymbalta for fibromyalgia and to help with RA, I read the paper work that comes with the prescription and noted the side effects of being on the drug, but there was nothing on just what might happen if you stayed on for an extended period, or had to stop taking the medication.
    At first my results were excellent with improved pain control, an increased feeling of well being, and good diarrhea management. Major side effect was inability to orgasm, despite keeping a strong erection for well over an hour!
    As I have been on the drug for over 4 years I have noticed quite a number of side effects for myself which appear cumulative – they will not be obvious in the short term trials that the company ran to get approvals.
    Firstly the slow development of tiredness. I was getting to the point where like a number of people on this site I could fall asleep anywhere, and at work in front of my computer, and while a 10 minute nap sometimes helped by the time I decided to come off the drug I could sleep all day. As a manager this was very difficult, so I had to change positions to help deal with this.
    Secondly like others I experienced brain zaps – but mine are more like a red hot needle suddenly being thrust into my brain! and with the constant ringing in the ears. these things are depressive in their right.
    Thirdly despite eating really healthy my cholesterol levels, triglycerides and blood pressure went up and have stubbornly refused to come down despite being on three drugs for hypertension.

    So after reading a media report from the University of Western Australia on the number of people who were experiencing side effects form anti-depressants I have been running my personal experiment on withdrawal.

    Its very important to know how this drug works in the body. The half life is very low, so the body gets rid of it very fast – in 24 hrs you have only about 1/8th of the starting dose and by 48 hrs its effectively all gone. I have done quite a bit of reading on serotonin and it seems possible that Cymbalta long term use might reduce the bodies ability to make serotonin in the gut (where 90% is made). When you go of the drug the body cant suddenly switch back to making serotonin so you end up with less circulating serotonin and the body taking more away (remember its a re-uptake inhibitor) – double whammy! and all the discontinuation syndrome effects can happen very quickly. Its probably not unlike some illicit drugs in this respect, but you don’t end up with a craving – just feeling so horrible that the Cymbalta is worth taking to feel good again.

    I had already experienced the Discontinuation syndrome, as to have orgasm required me to go off the drug for 48hrs. And the effects where quickly apparent. Diarrhea, headaches, scary dreams (almost nightmares) in which I had no control of the scene being played out (I have had control of my dream state since the age of 16). I could quite regularly kill 20+ people and have no qualms about it!
    So to stop I started reducing my dose from 60mg to 30mg daily.
    On 30mg the effect was very noticeable – the tiredness disappeared, and I started sleeping at night. the blurred vision which I had put down to old age started to go, and the brain fogging stopped and my thinking power was let go like a dam wall breaking.
    I was on 30mg for a week or so when I told my doctor what I was doing and he prescribed a lower dose of the duloxetine, which I took for another two weeks.

    I have now been off the Cymbalta for 4 weeks and have found it both easy and difficult at the same time. I have much more energy, work is much easier with not wanting to fall asleep continuously, and I can orgasm much more quickly. The bad dreams went away after few days, but the waking up with headaches then started and requires pain killers most days (as an ex-migraine sufferer who had the full blown syndrome, the current headaches are almost tolerable). And the blood pressure and pulse rate increase then started. After having stable BP for quite a few years I can wake up after a full nights sleep and now have 170/95 and a resting heart rate of 100 bpm! And I now have asthmatic type coughing.

    But before doing the withdrawal I started a probiotic strategy of 13 species of bacteria twice daily and with lots of fibre mainly from eating wholemeal bread, pasta and supplementing with 4-5 pieces of fruit. The rationale is that the Lactobacillus and Bifidobacteria are important in re-establishing the serotonin production in the gut. I also started magnesium supplementation daily as this helps with fibro in some people.

    Overall I think I am winning short term, but have no idea how long the discontinuation syndrome will last for (the ringing in the ears has not stopped yet). I do think the pro-biotic use is having an effect, as my diarrhea is largely gone and the fibro pain is really reduced, along with a major reduction in RA symptoms.

    Given we are all genetically unique, and how we interact with a drug is then unique, its not surprising that the effects, while on the drug and while withdrawing, are different in type, magnitude and duration for each of us. So there will always be those people it helps with little negative consequence, but many who have to experience the bad effects.

    Perhaps the FDA in the US should impose a compulsory test whereby all new mind altering drugs are tested on the Executives and marketing managers of companies seeking to market the drug, with independent monitoring of the consequences. We might get better drugs with fewer side effects, or more honesty in the claims being made about the drugs!

    Keep well

  12. Donna
    United States
    Reply

    After being on CYmbalta for 2 years I realized that the drug was no longer doing what it was supposed to do….treat my depression. It had in fact felt worse. My head was constantly in a fog. I felt depressed all the time. The only thing I can say positive was that it seemed to help with my arthritis. I was constantly agitated. I felt like my anxiety was going through the roof. Palpitations so bad I thought my heart was coming out of my chest. I could go on and on. I mentioned all this to my Dr and to my dismay he casually said if I felt that way I could simply stop taking it. Well, let me start by saying there is nothing simple about this. I am in day 7 with no end or relief in sight from this evil monkey on my back. I can only say I will conquer this and never ever take it again. If only I had been warned…. I wish you all luck in your endeavor to get rid if this drug out if you bodies. God Bless

    • Cindy
      New Jersey
      Reply

      I have now been off Cymbalta for 7 days. I am finding it hard to function while dealing with brain zaps, nausea, headaches, crying, and sweats followed by chills. I am praying that these symptoms subside soon. My insurance company advised my doctor that I had been taking it too long, (4 years), and that I should stop. I had also noticed that it wasn’t helping. I have been very lethargic, and gained quite a bit of weight. I am trying to take plenty of walks, drink lots of water and get a lot of rest. This does seem to help the symptoms a bit, but life goes on, and I have a lot to do. I will NEVER take one of these drugs again!

    • Deb A
      Canada
      Reply

      Do not just stop this drug. I went from 60 mg to 30 mg with no problem but then my Dr. said to take 30 mg everyother day for 2 weeks but that didn’t work. The roller coaster effect of drug then no drug was unbearable. So I weaned myself by getting empty capsules from a health food store and splitting the capsules in half, then in quarters and then none over a 2 month period. I have been off the drug for a week, but if it has a half life of 48 hours my body sure doesn’t know it. I still feel all the side effects of being on the drug, without the benefit of pain relief for my arthritis. Asked my husband to be on alert for any extreme behaviour on my part as everything I’ve read leads me to believe it can get worse again. Good luck, as we are all going to need it!

  13. Joann
    SOUTHERN CA
    Reply

    This is the my 1st time to EVER post a BLOG of any sort. I feel my story MUST be told:
    I will start by sharing that I am a Medical Director for a Medical Corporation and work with patients that suffer from severe depression and other brain disorders. With that said, I am acutely aware, from conducting patient In-Take consultations, the side effects individuals report from taking antidepressant trials.

    What I was not experienced in was actually taking an antidepressant medication trial.

    Background:
    I was diagnosed with Polymyalgia Rheumatica in 01/2014. My Endocrinologist prescribed Cymbalta for the chronic pain. I started on 30mg and increased the dosage to 60mg. After gaining 25 pounds and found the drug to be ineffective, I discussed with my Internist reducing the dosage to 30mg. After 4 weeks of taking 30mg, against my better judgement, I stopped taking Cymbalta 30mg.

    Here is what I experienced sometime shortly after stopping:
    – woke up completely disoriented
    – could not THINK!
    – experienced BRAIN FOG
    – difficulty navigating through my well known computer programs
    – could not comprehend simple emails
    – SEVERE memory loss
    – was very disoriented while driving; couldn’t figure out how to travel routes that I traveled for 35 years
    – SEVERE headaches
    – difficulty speaking
    – VERY irritable, impatient
    – mood swings
    After symptoms persisted I contacted my Internist several days later and reported that I thought I had a stroke or TIA. She said go immediately to the hospital. I did not, so she ordered a STAT brain MRI with/ w/o contrast.
    My MRI was normal. So I went to the Endocrinologist who originally prescribed the Cymbalta for my pain and the Internist who reduced my dosage. Both were not aware of ANY side effects from stopping Cymbalta! My Endocrinologist, who I had a great report with, became distant a very disinterested in my horrific experience. Suggested I get a 2nd opinion, when all I was seeking was will this go away or is there permanent residual side effects from taking Cymbalta.
    One month post stopping Cymbalta:
    – no longer disoriented
    – BRAIN FOG has cleared
    – driving and computer tasks are back to normal
    – still have daily MODERATE headaches
    – memory returning
    – NEW development- 3 days ago developed SEVERE pain in my mouth, radiating up into my cheek and ear. Went to dentist, normal x-rays. Was referred to an ENT specialists, diagnosed with severe mandibular neuralgia, nerve inflammation. Pain is so severe that I am taking a narcotic every 4 hours, to just be somewhat out of the severe pain zone, and prednisone three times daily. Can only ingest liquids and purred food. Have no idea if this is Cymbalta related, but seems suspect as it is occurring while I still have the Cymbalta headaches.

    In closing I think it is malpractice for physicians to order a drug and have absolutely no clue of the side effects and what a patient can experience post terminating the drug therapy. I have spent a great deal of time, money going to 3 specialists and diagnostic imaging, PLUS suffering extreme side effects that mimicked having a stroke. I am most grateful that it was not a stroke, but this is by far the worse experience I have been exposed to in my 57 years as a patient. Mind you it didn’t help with my Polymyalgia Rheumatica!
    I think this drug has potentially brain damaging side effects and should be pulled from the market by the FDA. If a drug can cause this type of reaction after stopping, it is very powerful and results in very obvious changes to brain chemistry.

    I hope this provides help as to what to expect when stopping Cymbalta. HOPEFULLY YOU NEVER START taking Cymbalta.
    VERY DANGEROUS DRUG!

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