A bottle of generic delayed-release Duloxetine (Cymbalta) 30 mg

Cymbalta was originally approved by the FDA in 2004 for the treatment of major depression. It is officially an SNRI-type antidepressant. In doctorspeak that means it is a serotonin-norepinehprine reuptake inhibitor and is somewhat similar to other antidepressants such as Effexor (venlafaxine) and Pristiq (desvenlafaxine).

The FDA also approved Cymbalta to treat nerve pain associated with diabetes in 2004. In 2007 the drug got a green light for anxiety and in 2008 the FDA agreed that it could ease the discomfort associated with fibromyalgia. It was also approved to treat musculoskeletal pain associated with arthritis and lower back pain in 2010. In other words, here was a drug that could relieve your blues and your aches and pains. And the drug company that makes Cymbalta (Lilly) has been aggressively marketing it as a good way to deal with chronic low back pain and osteoarthritis. Perhaps you have seen the commercials on TV promoting the pain relieving power of the drug with the slogan “Cymbalta can help.” It sounds almost too good to be true.

Ah…and there is the rub. Although there is a long list of serious side effects mentioned during the commercial, the video images seem quite reassuring and trump the scary message the FDA requires for this medication. So, let’s set the record straight. Here, without visual interference, are a list of potential complications associated with this medication.

Cymbalta (Duloxetine) Side Effects

  • Nausea, stomach pain, constipation, diarrhea, decreased appetite, vomiting
  • Dry mouth
  • Insomnia, anxiety, tremor
  • Dizziness, fatigue, sleepiness
  • Sweating, hot flashes
  • Blurred vision
  • Headache
  • Sexual dysfunction, lowered libido, erection difficulties, lack of orgasm
  • Liver damage
  • Serious skin reactions, rash, hives (requires immediate MD assistance!)
  • Glaucoma
  • Irregular heart rhythms
  • Bleeding problems
  • Blood pressure problems
  • Interaction with other drugs (leading to serotonin syndrome among other reactions)
  • Pneumonia
  • Seizures
  • Depressed mood, suicidal thoughts and behavior, suicide

Such a long list of side effects makes your eyes glaze over after the top 3 or 4. That is why we have included stories from real people so you can better understand what these complications feel like.

Even though such side effects are scary, there is another problem with Cymbalta. When people try to stop taking this drug they frequently report unpleasant withdrawal symptoms. An organization (QuarterWatch) that monitors the FDA’s database of serious adverse drug events has noted that:

“We observed a signal for serious drug withdrawal symptoms associated with duloxetine (CYMBALTA), a widely used antidepressant that is also approved to treat arthritis and back pain, anxiety, and fibromyalgia. In the first quarter of 2012 the FDA received 48 case reports of drug withdrawal identifying duloxetine as the suspect drug. They described a wide spectrum of withdrawal effects that began when the patients stopped the drug, including blackouts, suicidal thoughts, tremor, and nausea. Several cases involved hospitalization.

Probing deeper into the scientific record for duloxetine we found that withdrawal symptoms were reported in 44-50% of patients abruptly discontinuing duloxetine at the end of clinical studies for depression, and more than half of this total did not resolve within a week or two. In addition, we identified a serious breakdown at both the FDA and the manufacturer, Eli Lilly and Company, in providing adequate warnings and instructions about how to manage this common adverse effect.”

Doctors have taken to calling this “discontinuation syndrome.” These clinical words do not do justice to what it is like to stop antidepressants like Cymbalta, Effexor (venlafaxine), Paxil (paroxetine), Pristiq (desvenlafaxine) or Zoloft (sertraline) suddenly.

Sudden Withdrawal Symptoms

  • Brain “Zaps” (electric shock-like senstations in the brain)
  • Dizziness, light-headedness, vertigo, feeling faint
  • Headaches
  • Anxiety, irritability, hostility
  • Nausea, diarrhea, digestive upset
  • Tremor, hands shaking, nerve tingles, strange sensations
  • Fatigue, tiredness, lack of energy
  • Visual disturbances

Again, a list of symptoms does not do this problem justice. Below you will read some stories from people who have posted their comments to this website. We would love to hear your story, positive or negative. Share your experience with Cymbalta or any other antidepressant below.

Should you wish to learn more about dealing with depression through some other strategies, we offer our Guide to Dealing with Depression. You will also find a whole chapter on prescribing mistakes doctors make when treating depression and fibromyalgia in our book, Top Screwups Doctors Make and How to Avoid Them.

Cymbalta Withdrawal Stories from Readers

“My lovely, young daughter-in law, who was about to celebrate her 29th birthday, was prescribed Cymbalta, Klonopin, and Ambien and has committed suicide.

“She told her physician and her therapist that she’d had thoughts of suicide but no one took her seriously. She suffered from depression, as well as an eating disorder, and had very low body weight. She also used alcohol.

“Please remind your readers of the potentially disastrous effects these chemicals can cause when taken carelessly or in combination with alcohol.”
– D.G.

“I have been on Prozac over the last 20 years off and on and it finally stopped working. The last time I took it about 2 years ago I was taking the generic from Barr – the blue and white capsule. I was feeling as if I were in the deepest dark hole there ever was.

“My doctor put me on Cymbalta from which I had a lot of side effects such as palpitations, feeling constant dread, panic attacks, sweats, lightheadedness and general feeling of not being well.

“She added Abilify which put me over the edge. I was in the worst depression I have ever been in. Finally after living like this for several months, I asked to be put back on Prozac. I was taking the generic from Sandoz. When the prescription ran out I ended up on the big blue and white capsules from Barr.

“Over the last couple of weeks it has been constant crying spells, arguing with everyone and feeling pretty low. I talked to my doctor and she wrote the prescription for Sandoz only generic. The blue and white capsules are like taking a placebo. My doctor said she had had other patients who complained of the same thing and she had to write prescriptions for a certain generic or name brand.”

– P.J.

“I took Cymbalta for 3 days and thought I’d go nuts. I’m off it now and refuse to try any other drug like this. My main complaint was extreme hot flashes that estrogen wouldn’t help. I thought I’d be given Prozac, but was given Cymbalta instead. It was a rough 3 days and I stopped it last night. I am extremely tired yet cannot sleep at night. I think I was sweating even worse and my legs started feeling like I had Lyme disease again. And to be honest, within those 3 days of taking it, I didn’t contemplate suicide, but I had this crappy attitude of “who would care?”

– R.P.

“It took me 18 months to get off Cymbalta, with no doctor’s help. I can hardly believe that doctors have no exit strategy for this dangerous drug. I had to find this out on my own from reading and as soon as I weaned off that – about a month, the tinnitus that had occurred decreased almost completely. No doctor told me this.”
– Nancy

“My daughter experienced severe side effects when trying to come off Cymbalta – she had nausea, vomiting, lost peripheral vision for 24-48 hours, had shaking, etc. This was while she was doing a clinical in a hospital for college. Had she known she would have stayed on it until after clinical. I called the manufacturer and they acted like there were no such side effects from withdrawal.

“She too took apart the capsules and it took awhile, but finally she is free from that drug. I think it is a crime that the manufacturers don’t publish more detailed information concerning withdrawal. They could even make money selling a one month or two month step down prescription so individuals aren’t taking the capsules apart themselves.”
– J.K.

“I just turned 52 today. I went on a very low dose of Zoloft about 8 years ago to treat generalized anxiety disorder. It really did help for a long time. I recently have been pretty depressed (however I can cover it up really well) and my psychiatrist switched me to Effexor which was terrible for me. Now I’m trying Cymbalta which has not done anything either except make me feel more anxious and headachy and weird.”

“I am a registered nurse and I do not understand what the long term effects of these meds are and I am concerned. I really want to get off and see what I can do naturally for myself.”
– P.C.

“Getting off Cymbalta is challenging but not impossible. I, too, experienced the light-headedness, dizziness, and “brain zaps.” I described it as being able to “hear my eyes move.” It sounded like the light sabers on Star Wars. Very strange and disconcerting.

“The key is to do it very very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.

“Your doctor will probably be no help at all. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more. Be patient. I am completely off now and feeling GOOD.”
– K.T.

“I took Cymbalta for fibromyalgia and have just stopped taking it because of acute liver and GI pain- yes, pain! My liver poured bile into my gut and protested loudly! Cymbalta worked great on the fibromyalgia, but I had to stop.

“I agree that doctors don’t always realize how prescription drugs can alter your life so we must continue to advocate for ourselves.”
– V.C.

“I was prescribed Cymbalta ‘off-label’ to manage fibromyalgia pain When I stopped taking it because it wasn’t delivering on the promised effect of reducing my pain, I became so horribly depressed that I required hospitalization as I had become SUICIDAL!

“I will NEVER take another anti-depressant for an off-label purpose….such as Elavil/amitriptyline as a “sleep aid” which is very commonly prescribed.

“I believe it should be criminal to prescribe ANY drug for a purpose other than the one it was approved to treat.”
– Karen

“I’m a 76 year old man, my libido was very low. Taking Cymbalta for peripheral neuropathy added ED as a side affect of the drug. I had a testosterone blood test; it was 1/3 what the minimum should be. So I’m taking Androgel to raise testosterone levels and it is magic. I have great libido now and am working on minimizing the Cymbalta pills. In the meantime I have been prescribed Cialis for the ED. Each pill solves the sex problem for a couple of days.”
– R.H.

“I have the exact symptoms as everyone else and it’s been a week. I only took Cymbalta for 2 months, but the side effects from stopping it are horrible. My doctor didn’t, nor did anyone else tell me, about any side effects and I did read the insert. Most of the time the listed side effects of meds don’t bother me, so I figured no problem.

“From reading other posts on this website and on other sites, the drug seems to affect every person the same way. I would never have taken it for my neck pain if I had known about the likelihood of side effects. The worst part for me is the dizziness, the brain zings and the sudden burst of tears for no reason. I would never take this drug again. I think the FDA needs to do longer studies on all drugs and be honest with their findings and that doctors should be honest and tell their patients what really happens when you take Cymbalta.”
– M.O.

Please add your own experience below in the comment section.

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  1. Charlene
    Ft. Myers, Fl
    Reply

    Almost two years ago I was hospitalized for attempted suicide and after that I was put on Cymbalta for depression and pain from Fibromyalgia. I have also been on Gabapentin for pain, I still have much pain. Because I can’t work I have no income and am in the process of getting disability. I have no insurance, so my doctor arranged for Lilly to supply me with the Cymbalta. A couple of months ago I was able to get a free eye exam through the Kiwanis and the examiner told me my pressure readings were high and I may have glaucoma so I should see an eye doctor asap, of course, no insurance no can do. Two weeks ago I ran out of Cymbalta and hadn’t realized the year had passed , so now I have to wait for Lilly to re-certify me and send it to my doctors office, Thing is, I have been feeling so horrible since I ran out, I don’t know if I should go back on them when I have still been in pain anyway. My doctor said that if the two meds don’t help then I will have to start going to a pain clinic, again no insurance, no income, no can do. Since being out of Cymbalta I have not only been in pain, but have also had bad headaches, dizziness, lightheaded, blurred vision, heartburn, crying frequently for things as little as tv shows. I home school my grandson and have noticed being less patient with him and just angry in general. My daughter is a single parent and works hard to support the three of us. I already feel bad enough that I can no longer contribute financially, but to not be able to help as much with household things, just makes me feel even worse. I do get a few food stamps each month so I can at least pay for some of my own food, and on that subject, feel like crap, can’t eat much, and have gained almost a hundred pounds since going on Cymbalta! I am so miserable I just don’t no what to do. Any help out there? I am sorry for going on so long, I just needed to vent I guess.

  2. kp
    douglas, Ga
    Reply

    Oh my!! I have been trying to be optimistic and trying to boost my courage to starting on 30mg Extended Release Duloxetine in a couple days. After reading all of these comments, I have just undone a lot of it. For me, the only problem has been that I took Paxil several years ago, and it was a nightmare about 5 hours after the 1st pill. Treatment was for panic anxiety disorder with some agoraphobia. Drs told me to never take another SSRI med like that. Well my Dr now feels this SNRI Duloxetine (cymbalta generic) will help my pain issues as I cannot take other pain meds, just advil. Also she feels it will improve my quality of life with the Panic Anxiety Disorder..but wants me to continue on with the Aprazolom that I have taken for years, cause it is the only thing that has ever helped me with no side effects. Dr says only side effect i probably will have is sedation. To me, that would be great if that is all. I just don’t want the horrible anxiety panic intensity, hot & cold flushing, and brain burning feelings that I had on the SSRI Paxil years ago. Took me 12 hours plus to get over that..just from the first dose. I am trying to be cooperative and get over the fear of these types of meds, yet Dr says it is not a SSRI and is an A-typical med. So….now…scheduled for 1st 30mg dose in two days… and oh my…..now I don’t know how long I should expect any bad, if any, side effects to appear. How long did it take for any to show up after the 1st dose? Sorry such a long rant..but really wondering. With the paxil it was like 4 or 5 hours before i felt the horrible devastation from the first dose. So….

  3. Julianna
    Pennsylvania
    Reply

    On the bright side I lost 6lbs in 48 hours. Horrific how it happened but still amazing. When I first started having the symptoms I seriously thought I had food poisoning. Then I remembered I didn’t take my meds and didn’t eat anything I normally wouldn’t. Whoooo, will never ever miss a dose again as long as I am stuck on this medicine. Might consider coming off of it.

  4. Julianna
    Pennsylvania
    Reply

    I have been taking cymbalta for almost a year more or less now. At first I was on the 20 mg and it was doing nothing for my nerve pain. We then upped it to the 30 mg. I still feel like it isn’t doing much but point is before I was on and off taking it never really had a problem. Recently the past couple of months I became almost religious about taking it every night. This week I didn’t take it two days in a row and I had the WORST withdrawal symptoms ever. Constant diarrhea, nausea, muscle pain, stomach cramping, crazy dreams, insomnia, restlessness, vomiting, etc. It has been absolutely awful.

  5. Jess b
    West yorkshire
    Reply

    I have just been given these to take along side another drug for depression and I have to say all these comments have made my mind up before I try them properly, I’m so glad I read up on this drug because I felt that my doctor at the hospital was not listening to me and did not really understand my mental health problems and was very insistent I took them. No way am I taking them now.

  6. Jo
    United States
    Reply

    I took Cymbalta for fibromyalgia…really helped, but could not afford a refill which was $500 for 90 days. Stopped it cold. After about a week, I started having all kinds of pain, weird feelings. I considered suicide, but didn’t want to leave my 2 little dogs, because there is no one to take care of them. I could not even attend church for more than a month.
    Now I am having electric-type pains in my shoulder…been almost unbearable for 3 days.

  7. Lisa
    Canada
    Reply

    I learned the hard way. I ran out of Cymbalta and forgot to refill, so I quickly had missed a couple doses. I ended-up in bed unable to walk because of the dizziness and nausea. I sent my daughter to pick-up my refill but could not keep it down. I tried taking gravol but couldn’t keep that down either. Finally, after 5 days in bed, I sent for gravol (for nausea) suppository. Of course no problem keeping the suppository ‘in’–within 45 minutes I could take my Cymbalta and by the next day my body was back to normal although 8 pounds lighter.

    Cymbalta has worked for me other than the few times that I forgot to pick-up my meds–you think I would learn. I did reduce my dose by 1/3 last year and had no problems.

  8. Nancy
    Sarasota, Florida
    Reply

    I have tried to go off of Cymbalta in the past by gradually reducing the dosage, but even a slight change caused many withdrawal symptoms. I finally decided to stop taking the medication completely and have been experiencing these same symptoms for over three weeks. I know different people experience different levels of tolerance, but I can’t find any information on how long this drug takes to clear my body or what, if any, permanent damage may occur. I am glad I live alone and have retired because there is no way I could have done this and participated in society without it having affected relationships with people. Knowing the withdrawal symptoms has helped me to realize what is happening physically and mentally to my body, but the struggle goes on to cope with the pain, tears, nightmares, disorientation, anxiety, hostility, fatigue and feelings of hopelessness that continue to haunt me daily.

  9. Michelle
    Ohio
    Reply

    I suffer from osteoarthritis in my feet, knees, back, and neck. Due to the beginning stage of a stomach ulcer from self medicating with over-the-counter anti-inflammatories the doctor prescribed tramadol. I was able to take 1 every 6 hours. I started out with taking it about 1 every 8 hours but as time went on it seemed as though my pain was intensifying. So, I increased my daily dose to 1 every 6 hours. Eventually, I got to the point where I felt all over pain daily and wasn’t sleeping well. Then, my doctor prescribed a muscle relaxer to take at night. Still feeling poorly after about 3 months of this combination, she prescribed Cymbalta. She started me out on 30mg a day for 2 weeks and then increased it to 60mg a day. I have to admit, initially, it was the best thing she could have prescribed. The all over pain I was experiencing subsided, however, I began experiencing side-effects of the drugs (mainly blurred vision and sexual disfunction). The blurred vision did subside to some degree but over time I would find that I had trouble focusing. Some days would be ok, others would not. Due to the sexual disfunction, she had be degree my dosage to 30mg. Keep in mind, I’m still taking tramadol, the relaxer and now Cymbalta. Due to Cymbalta controlling my pain so much better, I decided to discontinue the tramadol. I really didn’t want to take all of these medications if I didn’t need to. Knowing full well that I couldn’t just stop at once, I put myself on a step-down process. I reduced my daily intake a little bit each week. As I did this process, I realized that I was having less and less overall pain. But, I was beginning to recognize that I had this over-all feeling of being unwell but, couldn’t explain why I just didn’t feel well. I stopped tramadol about 6 months ago and have recently weaned myself off of Cymbalta as well. The doctor had reduced my dosage to the now available 20mg capsule about a month ago due to continued side-effects. This allowed me to wean off of the medication fairly easily. Again, I stepped down to the 20mg and then stepped down to taking it every other day for a week, to every 2 days for a week, etc. I did not have any severe withdrawal symptoms by doing it this way. I highly recommend that if you want off of Cymbalta to reduce your dosage slowly and use a step-down process. My only symptom I seem to have right now is my vision is a little weird. I’m having difficulty focusing, especially my distance vision. I’m hoping this will subside once the medication is completely out of my system.

    In retrospect, I now realize that the majority of the over-all pain that led to the additional medications was mainly caused by the tramadol itself. And, now that I am off of the Cymbalta as well, the sick feeling or just feeling unwell has subsided and I’m feeling more like myself (finally). I do, however, still have the Osteoarthritis pain but am again trying to manage it with over-the-counter anti-inflammatories. I just try to limit how much I take and I take Omeprozol for my stomach related issues. The OA will be an on-going battle and a knee replacement is in my future even though I’m only 52. Living a sedentary lifestyle is not good for my over-all health, including my mental health. Finding a good orthopedic doctor with progressive ideals is key in realizing that joint replacement is best treatment for OA and allowing people to get back to a healthy active lifestyle.

  10. Linda
    Reply

    no comment at this time. Just reading and feeling very sick as have been waiting for Prior Authorization because of new insurance since last week.

  11. Elizabeth
    PA
    Reply

    I have been on cymbulta for sometime now and I am always so afraid to run out because the one withdrawal affect I notice is HORRIBLE nightmares! So bad I am afraid to even sleep! After reading others comments it really makes me think about this medication. I sweat day and night like crazy, have swelling every morning and weird feeling/pain in my arms and sometimes legs for the first few hours of each day, wired heart beats often, I can’t even think of everything off the top of my head but here I am again without my cymbulta for now only 2 days and I have been woken in the middle of the night by another horrible nightmare, hands, arms, legs, feet swollen and all feel funny, eyes feel like there floating and I just feel odd, and not to mention I’m afraid to go back to sleep! Does anyone else have this problem?

  12. Mike
    Reply

    I’ve been on 60mg if Cymbalta for 4 months to treat anxiety and depression. Other than the occasional hot flash I’ve had no side effects and my quality of life compared to a year ago is so much better. As far as an exit strategy my psychiatrist already has plans to slowly wean me off once she feels that I am ready.

  13. Joan
    Manitoba
    Reply

    For a year and a half, I took Cymbalta for severe depression, PTSD.
    After counselling, doctors and many trips to the phys. I decided it was time to wean off Cymbalta. Under the doctors care. I weaned off 60 mg daily to 30 mg for 2 weeks. Than to 30 mg for 2 weeks, than to 30 mg every second day for another 2 weeks. My final dose was last Sunday with Celebration in hand. Today is Thursday, four days of being Cymbalta free. I woke up very light headed, feely dizzy, and forgetfulness all morning. If this is the only side effect to weaning off of it. So be it. I am determined not to let a drug run my life. I will update my weaning experience. April 16, 2015

  14. Sarah
    Minneapolis, Minnesota
    Reply

    I was given cymbalta for my ankle pain. At first I was given 30mgs and tolerated somewhat ok. After doctor increased to 60 (after a month) i started having body twitching and jerking. It was so bad it was hard to sleep . I decided I have had enough so while on vacation, I decided to stop this medication. I tried weaning by not taking it and then take a pill then stop. I had the worst withdrawal symptoms EVER. first came insomnia. I couldn’t sleep for anything!! Then after day four, I got severe nausea. I could barely speak. I was so severely sick. I was shaking and needed to puke all day. For three days. It felt as though my insides were failing. 100x worse than any hangover. I took this medication for about two months.
    This should not happen. This is a terrible withdrawal. I may not be a drug addict and know what they go through when they try to get clean. I feel like now I understand what that talk about when they the withdrawal is worse than the drug itself. Never had a reaction that bad.
    I also don’t take any other medications daily. Cymbalta was the only one I took everyday.

  15. Nikki
    Uk
    Reply

    I have been taking 90mg cymbalta for about 6 years for chronic back pain and deep depression due to the constant pain- I started feeling in credibility sick recently after taking it with upset stomach feeling agitated and finally being physically sick – serotonin syndrome I I have been diagnosed with so I have had to stop it dead.

    The withdrawal is horrendous my doctor has no explanation why it happened now and I am scared to take anything other than my pain patches and lyrica. I am suffering with upset tummy sickness brain zaps confusion feeling trembles and basically not with it- I have been given amititripoline bus cannot bring myself to take it after feeling so ill after taking cymbalta. Has anyone else experienced serotonin syndrome after taking this drug for so long?

  16. C A
    Canada
    Reply

    I was on 30 mg of cymbalta for 2 weeks then one week at 60 mg. could not tolerate the side effects which included tinnitus, heavy sweating, increased anxiety , nausea, diaherra, insomnia, mental confusion, muscle twitches , fatigue. Decreased the dose to 30 mg for a week, then discontinued. I’ve been off it for 5 days and I feel terrible. The tinnitus is driving me nuts and the other symptoms have not gone away. I really hope the constant buzzing in my ears stops soon. Terrible experience

    • christine
      United States
      Reply

      I have also been on cymbalta for years. I came to this site because I am increasingly having more symptoms. Depression is bad with crying spells getting worse. I’m nauseated and take medication for GERD. My memore and attention span are getting pretty bad. I have trouble sleeping so I was prescribed klonapin and also used to supplement the cymbalta for anxiety. At first cymbalta worked but now I’m thinking it’s causing more problems than its worth. As for helping with pain it does absolutely nothing. I have always wanted to get off the meds but afraid the panic attacks would start again. I can’t go there again. I am wiped out during the day. Just feel exhausted and yawning by mid-day but not really sleepy. I appreciate the suggestion to take a few balls out of the capsules over a long term period. I think I will try this and see how it goes. I wasn’t able to work with the crying spells and feeling like people didn’t like me and that I’m worthless. I had to quit my job. I am now trying to apply for jobs again and have to get myself together. If I miss my cymbalta just one day I have trouble breathing and anxiety levels are getting higher on it. I think this is my signal to get off now.

      • Claire
        United States
        Reply

        I think you perfectly pinpointed EXACTLY what I’m dealing with on Cymbalta right now. How long have you been on it and has it been the same dosage? I’m currently on 90 mg and have been for the past couple years but I feel like these spells of crying/feeling low are just now starting and getting worse!

  17. Oncomom
    South Africa
    Reply

    I was prescribed Cymgen (drug name in South Africa) in 2012 for severe depression after my little boy was diagnosed with cancer. I started off on the 30 mg dosage, which I took for 2 weeks, and it was then increased to 60mg per day. I felt an immediate improvement and took it for 2 years. For the past couple of months I’ve been trying to wean off it (following my doctor’s instructions on how to come off it), but have been suffering from debilitating withdrawal symptoms. I decreased the dosage from 60mg to 30mg per day for a month, then took the 30mg dosage every alternate day for a few weeks, and am now taking a 30mg tablet every third day. My withdrawal symptoms include brain zaps, headaches, constant and extreme nausea, stomach cramps, chronic tiredness, dizziness, shaking, memory lapses, irritability, mood swings, suicidal thoughts, and nightmares. Although I found it a great drug for depression (however, it does have extreme side effects, of which I suffered from several), I would definitely not recommend it to anyone as it is so difficult to come off it.

  18. lynnette
    florida
    Reply

    I was taking cymbalta for my leg pain for about a year. For 11 months it worked wonderful except during those times of the month. My perscription ran out on a Thursday but I had a appointment that friday. I ended up missing it. By saturday I was extremely tired and dizzy and when I tried to nap I had nightmares. I also woke up aching in my bones everywhere , not just my legs. Yesterday I called my doctor to see if stopping the cymbalta like that was causing my symptoms. He didn’t know but said “no more cymbalta” a weird thing was the first nightmare consisted of me dreaming I was having seizers and feeling like I was suffocating. My little girl has epilepsy and sever apnea. I chalked it up as subconscious but now I know cymbalta played a part and wonder if I was having “brain zaps” no suicidal thoughts or aggression, I am just severely exhausted. And this is day 5 without…..

  19. SBM
    Georgia
    Reply

    I was prescribed Cymbalta by a neurologist after battling chronic migraines for 5 years. I have been on 20mg a day for 5 or 6 months. Cymbalta has been a wonder drug for managing my migraines…but has wreaked havoc on my body.

    The doctor who prescribed Cymbalta also prescribed 2 other drugs that I quickly found out increased risk of serotonin syndrome. When I increased my dosage to 40 mg a day per his orders, I experienced a rash, chest pains, high blood pressure, etc. and had to see emergency care. I was desperate so I continued Cymbalta, but studied up on the drug interaction warnings (and sent FDA articles to my neurologist).

    After taking the drug for 3 months, I began having severe abdominal pain…CT scans, ultrasounds, radio isotope injections, etc…even had my galbladder removed and NOTHING helped. After having a cystoscopy to check my ureter and bladder for inflammation, tumors, stones and finding nothing again…I began wondering about Cymbalta side effects.

    I did research and found folks who experienced unexplained abdominal pain. I am weaning myself off now. So far, it is manageable…although I have run into a couple of walls and almost fallen and I am having extreme dry mouth and difficulty sleeping. I am willing to keep going through this, and risk returning to the hell that was my life with daily migraines, to get off this drug.

    One doctor I saw referred to Cymbalta as being the closest thing he’s ever seen to rat poison. I was desparate for relief from Migraines and so I laughed him off. After thousands of dollars in medical expenses, unnecessary surgery, and months of pain and worry, I wish I had listened more closely.

    Good luck to you out there.

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