Q. Getting off Cymbalta is challenging but not impossible. I experienced light-headedness, dizziness, and “brain zaps.” These felt like being able to hear my eyes move. It sounded like the light sabers on Star Wars–very strange and disconcerting.
The key is to reduce the dosage very, very slowly. Take the capsules apart and begin by removing 5 or 10 of the tiny balls inside. Do this for a week or so, then slowly increase the amount you remove each week or two as you can tolerate it.
Your doctor may not be of any help. Mine wasn’t. He instructed me to wean off over a two to three week period and I almost lost my mind. I did it myself over about a YEAR or more.

A. We appreciate your detailed description of how you got off Cymbalta (duloxetine). The FDA does not require manufacturers of antidepressants such as citalopram, duloxetine, paroxetine, sertraline or venlafaxine to provide detailed instructions on gradual withdrawal. We think this is a serious oversight since “discontinuation syndrome” is common and challenging.

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  1. Deborah jordan

    I took a chance after researching getting off Cymbalta. For years I was on 120 mg. a few months ago I got down to 30 mg no problem. But I could not stop the 20 mg. I experienced brain zaps, dizziness, tinnitus. And other awful side effects. I started 7 days ago, taking the beads out of the capsules. 7 a day. My only side effect I have is a little feeling of anxiety, and muscle aches. Hopefully I get through this, I’m getting off it for good. I feel this is the best way for me.

  2. Semo

    I am trying to get off the generic version of Cymbalta and am in the beginning stages now. I am in my mid 40’s and have been on it now for a couple years due to depression. I have noticed since trying to skip a day or two and take my 30mg tab, which i’ve been steady on with no increases, that I get stomach tremors and can see my skin move on my lower stomach area. I have never had any other side effects other than my sex drive drop to zero and i am married and used to be a sex maniac. Now I enjoy just laying in bed after work and going to sleep.

  3. Karen

    Need to wean off Cymbalta.

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