Go Ad-Free
logoThe People's Perspective on Medicine

Antidepressants Cause Sexual Difficulties

Q. My husband has suffered from depression for years. It got really bad last winter and I finally convinced him to see a psychiatrist.
Ever since he started taking sertraline he is a different person. Things are so much better in every respect except one. When we make love he cannot reach orgasm. He tries and tries and cannot ejaculate. This is tremendously frustrating for both of us.
I suspect the sertraline might be responsible, but he is too shy to discuss this with his doctor. How could a medicine for your brain affect your sex life?

A. Antidepressants like duloxetine, fluoxetine, paroxetine, sertraline and venlafaxine can be helpful for many people who suffer depression. All of them, however, are capable of interfering with ejaculation. Women may also experience this side effect as an inability to achieve orgasm. These drugs modify brain chemicals, especially serotonin which seems to play an important role in sexuality.
Some urologists even prescribe these drugs for men who complain of premature ejaculation. They can slow down orgasm and prolong intercourse.
Our free guide to Drugs That Affect Sexuality. It discusses the sexual side effects of a number of commonly prescribed medicines for men and women. It also addresses libido and impotence.
Your husband should discuss his difficulty with his doctor. This side effect is not uncommon. Certain other antidepressants may be less likely to produce this complication. Bupropion (Wellbutrin) in particular seems to sidestep sexual problems. If anything it might improve matters.

Rate this article
star-fullstar-emptystar-fullstar-emptystar-fullstar-emptystar-fullstar-emptystar-fullstar-emptystar-fullstar-emptystar-fullstar-emptystar-fullstar-emptystar-fullstar-emptystar-fullstar-empty
0- 0 ratings
About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”.
Tired of the ads on our website?

Now you can browse our website completely ad-free for just $5 / month. Stay up to date on breaking health news and support our work without the distraction of advertisements.

Browse our website ad-free
Join over 150,000 Subscribers at The People's Pharmacy

We're empowering you to make wise decisions about your own health, by providing you with essential health information about both medical and alternative treatment options.