red apples

Q. I know that grapefruit juice is a problem with my blood pressure pill felodipine. I wonder about other juices like apple and orange juice. Will they affect this or my allergy medication fexofenadine? It is so hard to tell what is safe to eat or drink with your medicine.

A. Grapefruit juice can indeed cause problems with many medications including felodipine (Plendil), simvastatin (Zocor) and atorvastatin (Lipitor). Blood levels can rise and that may cause unanticipated side effects.
Other fruit juices may have the opposite effect on certain medications. Fexofenadine (Allegra) is an allergy medicine that might not work very well if taken with apple, orange or grapefruit juice. Such juices may dramatically reduce the absorption of fexofenadine. This could mean there is not enough medicine to relieve allergy symptoms for some people (Pharmacogenetics and Genomics, Feb., 2011).
Many people get in the habit of taking their medicine with juice. It is probably a better idea to take pills with water. This is especially true for antibiotics, blood pressure medicine and drugs to prevent organ transplant rejection.

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  1. Jennifer Y.

    I have been told not to let my son drink orange drinks or citrus drinks with his allergy pills. What exactly can he not have? His allergy meds are Loratadine tablets.

  2. JJ

    Is there a fexofenadine free allergy medicine? I (according to doctor-have a very ‘allergic nose’- however, each time I’ve taken that script- I break out in large welts on chest and torso.

  3. ds

    I knew grapefruit juice with Lipitor was a no-no, but never knew why. Thanks for the answer.

  4. WW

    Are there any foods or juices that I should avoid with Linsinopril/hydrochlorozide? I have recently started taking this for high blood pressure.

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