Q. I know that grapefruit juice is a problem with my blood pressure pill felodipine. I wonder about other juices like apple and orange juice. Will they affect this or my allergy medication fexofenadine? It is so hard to tell what is safe to eat or drink with your medicine.
A. Grapefruit juice can indeed cause problems with many medications including felodipine (Plendil), simvastatin (Zocor) and atorvastatin (Lipitor). Blood levels can rise and that may cause unanticipated side effects.
Other fruit juices may have the opposite effect on certain medications. Fexofenadine (Allegra) is an allergy medicine that might not work very well if taken with apple, orange or grapefruit juice. Such juices may dramatically reduce the absorption of fexofenadine. This could mean there is not enough medicine to relieve allergy symptoms for some people (Pharmacogenetics and Genomics, Feb., 2011).
Many people get in the habit of taking their medicine with juice. It is probably a better idea to take pills with water. This is especially true for antibiotics, blood pressure medicine and drugs to prevent organ transplant rejection.