Women who drink sweet beverages rich in the sugar fructose have a higher risk of developing gout. This inflammatory condition leads to painful joints caused by uric acid crystals precipitating in soft tissue. Fructose raises uric acid levels, especially in people who have a history of gout. Because high fructose corn syrup is inexpensive, it is widely used to sweeten soft drinks and fruit juice. The Nurses Health Study provided data from almost 80,000 women for more than 20 years. Dietary analysis shows that women who have two or more servings of sweetened soft drinks or juice daily have double the risk of developing gout.
[JAMA, Nov. 24, 2010]