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Study to Compare Brand Name and Generic Antidepressant

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Q. Is there anything new on the generic version of Wellbutrin XL? My wife had done well on the brand name and then the Watson generic bupropion for several years. She was abruptly switched to Teva Budeprion last spring. Gradually, her depression returned. Within a month she was on the brink of suicide.

When I realized how severe her situation was, I ran out and purchased brand-name Wellbutrin. It took less than a week for her to return to her normal cheerful self.

I work for a pharmaceutical company and I would never have thought there could be such an issue with a generic. I reported her case to FDA's MedWatch, but I wonder if there will be any further study of this issue.

A. The FDA and Teva have come up with a plan to compare blood levels achieved with the generic antidepressant to those with the brand-name drug. Teva intends that this study will reassure people that anecdotes like yours are unrelated to its generic product. The protocol requires volunteers with depression to stay in a clinic for at least 24 days, but travel and a stipend are provided. Anyone who is interested in participating may get more information from California Clinical Trials: 818-254-1600.

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Took generic Wellbutrin XL and got depressed and forgetful. Switched back to Wellbutrin XL and all problems went away.

I also take antidepressants - fluoxetine and bupropion - and had been filling my prescriptions at a big-box chain store. I noticed recently when I picked up a refill that the color of the capsules for my fluoxetine had changed, but didn't pay much attention to it.

Within a week, I was literally climbing the walls and was becoming very depressed. Mentally, I started going through every single thing that could be causing this, and the only thing that was different, that I could come up with, was the possibility that the "new" fluoxetine could be the problem. I checked with the pharmacy and sure enough, they had switched to a new provider for their fluoxetine. The pharmacy was nice enough to give me the name of the previous provider (Barr), and I called around to different drugstores, eventually locating one that carried fluoxetine distributed by Barr.

Within two days of taking my "old" fluoxetine, I felt 100% better. With the next refill, however, even though the label said that the drug distributor was Barr, the capsule color was different. Once again, I could not tolerate the new form of fluoxetine, and after doing some research, found out that Barr had bought out another generic drug maker, and so technically, even though the label said "Barr" the drug was coming from another source. My doctor ended up switching me to a different drug entirely, and thankfully, I'm doing well on that.

I also experienced significant problems on generic Wellbutrin XL (purple pills). Not only did my depression symptoms resurface, but there was a significant effect on my sense of taste. I could no longer tolerate any naturally sweet foods, not just candy and cookies, but apples and tomatoes, indeed anything that contained sugar, including Town House crackers and country dijon mustard. Oddly enough, milk (lactose) tasted fine, but all foods containing sucrose and fructose caused an awful, disgusting aftertaste.

After an MRI determined that there was nothing anatomically wrong, my doctor rewrote my prescription to "brand name only" Wellbutrin XL. It's been several weeks, and, for the most part, my sense of taste has returned to normal, but some sweet foods still taste "off' to me. I think this must be a bad drug.

Teva's generic gave me a tremendous headache after a single dose. I thought it might be a fluke but it happened on three other occasions (same bottle, though).

A few years ago, my psychiatrist explained that generics are allowed to range from 80% to 120% of the stated dose. Recently he gave me a printed copy of the article, link shown below. We had no idea of the possible problems with generics as explained in the article. Looking back, I think I got into trouble when I switched from brand name Prozac to a generic prozac. I'm on another brand name drug now, but my mood instability and resulting problems may have been because of the switch to a generic.


http://www.self.com/health/2009/06/dangers-of-generic-drugs

I suffer from severe clinical depression and have taken 300 mg of Teva generic budeprion XL daily for 2 years. Last month my pharmacy switched from the generic manufacturer Teva to Actavis. The Teva product had worked fairly well (some nausea) but left a low level of depression symptoms.

After taking the pills manufactured by Actavis for about 10 days I noticed that I felt much more alert. My mood was better. I was doing a lot more and my thinking was clearer. It was at that point that I checked and found that the manufacturer had been changed from Teva to Actavis (apparently an Icelandic company??).

Note: My depression is longstanding and has been so severe that I stopped working and went on disability. The Teva generic did not bring me back to normal at any time. Has anyone else had a similar experience with the Actavis product? I still find it difficult to account for feeling so much better. Do these products deliver the medication into the bloodstream differently?

I tried the generic for effexor xr for 1 day and felt the difference rite away I called my Dr. and changed it back 2 the name brand the next day. Any one who thinks generic and brand name drugs are the same is wrong. Everyone knows that the insurance company is just greedy, they keep your money and you pay the price with your health!!

I was switched from Teva to Actavis and am experiencing severe depression symptoms. These are as bad or worse than any I've every had and I'm really worried. Short of paying the full price for Wellbutrin name brand, what recourse do I have with pharmacy or insurance company to get the Teva back or change to Wellbutrin name brand? They say it meets with FDA standards, but I'm having a psychological crisis and this is the only variable that has changed in my treatment. What can I do?

I have prescribed generic Wellbutrin for dozens of patients and I take it myself. Neither I nor my patients have had any problems with it. I am completely comfortable with this generic drug

I would like to add my experience with Wellbutrin- brand and generic. Wellbutrin SR (brand) was a godsend, started taking in 2001, really turned my life around. When the XL came out I took that and it was ok... then was put on XL brand and symptoms returned, like I was taking nothing, stopped taking it after 3 months, every day after 1 hour of taking it I had to stay away from people as it made me feel so horrible (mentally) & anxious.

Depression returned but not as severe, asked to go back on SR but given a generic, I gave it a few months but felt no better and Googled problem with Wellbutrin and told my Doctor what I had read online about percent of release of active ingredient in some generics- he put me on the SR brand, saying the insurance company wouldn't like it but too bad.

I am fine and will probably have to take it the rest of my life. My other meds-simvastatin & trazodone (for sleep)are generic and have had no problems.

I've been on the big yellow 300 mg Buproprion XL for about 6 months and my last refill was filled with Actavis (smaller white ones). While the old ones (TEVA, I believe) made me feel great, I've been doing poorly on Actavis. I thought that I had been given the wrong pills completely until I called the pharmacy and found out the manufacturer had changed.

I'm unsure if the side-affects are worse - I had assumed I was just ill with a mild flu or cold, but the headaches and nausea may be from the actavis pills. I certainly feel more unmotivated, lethargic, and sadder than since I started taking Buproprion.

It looks like many people have a worse reaction to the TEVA pills than brand name Wellbutrin and that there may be a different release rate. Perhaps my body deals better with the release rate of the TEVA pills than the Actavis. If only there was a way to specify a certain brand on a prescription, rather than just "no generic".

Without my knowledge my pharmacy switched my generic from Teva to Actavis. I thought the pills looked different but figured Teva changed them because all I was looking for on the bottle was generic for wellbutrin. Well by the end of the month, I was so discouraged I called my Doc.

I had gained five pounds and was having a terrible time with memory and concentration etc... Then I had to call around to find a pharmacy that could fill my script with Teva generic. It worked totally different for me than Actavis.

A friend was switched and also had a bad experience. I saw your article and recommended he call the CCT number you provided. He called and was scheduled for an appointment. So glad he called. Thanks for keeping us informed.

I was taking name brand Wellbutrin XL and CVS pharmacy didn't deviate from the doctor's name brand only recommendation, but when I switched over to mail order pharmacy and submitted the prescription form with the "do not substitute generic". Well, guess what they did anyway, claiming they had called my Dr's office and said they were given permission from my doctor.

I am literally ready to climb the walls. I can't stand it anymore. I was just fine on the name brand, but the generic just makes me seem like I'm not on anything and I'm depressed and i have no hope.

I was switched from Wellbutrin Sr to a generic about two months ago. A couple days after the switch I crashed bad, then after a week seemed to level off a little bit, but haven't been the same. I mentioned this to my doctor and he insists the generic is exactly the same as the brand name and that it must be something else. I find this hard to believe. Anybody else have this problem?

Me too!!! I'm doing terrible on the Actavis. I too feel more unmotivated, lethargic, and sadder. Crazy mood swings. I feel like I'm going nuts.

I don't know what to do-- I read that Teva releases faster in the first 2 hours. If that's the case, I'll break the Actavis pill. I'm on 300XL.

Teva works for me.

I've taken brand name Wellbutrin several times during the past years for seasonal depression. This time around I was given the generic Teva brand for Wellbutrin XL, 150mg x 2 a day. Had to stop taking it after one month due to severe insomnia, worsening depression, mood swings, constipation, & nightmares. Took a 'drug holiday' for a week then went back on the brand name Wellbutrin. After about 3 weeks I was back to normal and living life again.

Wow, who has the time to stay at a clinic for 24 days to test blood levels? I would gladly do it if the requirements were not so strict. Maybe, when there are two many "anecdotes like these", something is wrong and one needs to pay more attention... and be a bit more sensitive to the people whose well-being has been compromised by Budeprion.

I was fine on the Watson generic, but did not do well on Teva. Does anyone know what happened to the Watson version?

Teva is the worst and I can't believe nothing has or is being done about this generic..... it is soooo unfair to have to pay the full price for a medication like Wellbutrin XL that works so well for people. I was on Wellbutrin XL and was great!!! I eventually had to pay full price for Wellbutrin or switch to the Generic Teva so of course I switched to generic because I figured it couldn't be that bad.

Man was I wrong, I was having panic attacks, I felt like I was going to die, I couldn't sleep and I was a train wreck, not to mention I noticed my sinuses getting worse like my head was going to explode! I decided to not take anything at all, I felt better for a few months but I now realize I need the Wellbutrin XL back. What the hell am I gonna do, I can't afford to pay this huge fee every month.

I was put on Wellbutrin XL for weight loss. Years ago I had been on Buproprion the generic and did great. This time they put me on the TEVA Budeprion. I knew that sounded odd. Never heard of it and I'm an RN. Awful side effects, Headache at 5pm every night until the next am dose, terrible taste in mouth, tired all the time... and no weight loss after 2 weeks, Will ask Dr. Tues for new script for DAW. I gained 40 lbs over a year in spite of eating high protein 1200 cal diet and hrs of exercise a day. I am so discouraged! I had hoped I would also like many lose weight on Wellbutrin

I started off on the generic (Teva) Wellbutrin XL 300 mg about 7 months ago. I never took the brand name so I do not have any experience comparing the two. Teva Wellbutrin worked seemed fine for me. It was a large yellowish pill with a strange cool feeling in my throat for a while after taking.

For 4 months I took the Teva yellow pill. 3 months ago Target gave me small round pills that was the size of an aspirin (no idea what generic this was?). Then, two months ago I switched my pharmacy to Walgreens and the again the pills looked completely different (medium white oval and did not have the cooling sensation) and I saw that it was made by Actavis now.

I feel like the Actavis version is doing more harm than good for me. I feel lethargic, horrible mood swings, an empty/numb feeling most of the time, and unmotivated. Watson, I believe, merged with Actavis, but I am not sure what happened to Teva. Anyone else having issues with their Wellbutrin generics being changed?

In the previous post, I meant to say did Watson, Actavis, or Teva merge? Or do certain pharmacies just carry one generic brand or another? I just don't want to be bounced around from one generic to another which seems to be the current case.

I have never been on Wellbutrin, but I started on the Actavis Buproprion XL 150 4 days ago. So far, I have felt nothing like I thought I was going to feel. I have felt spacey, lethargic (fell asleep after work), tremor, and no increase in energy or sex drive. My chronic pain got worse, and last night I woke up several times feeling deep sadness/hopelessness. I had a vivid nightmare where my family was taunting me and wanting me to hang myself.

I hope this negative experience is only due to the generic version of Wellbutrin, and I will try the brand name as soon as I can.

In January 2007 I switched from Wellbutrin XR to the Teva brand. My depression worsened, with lethergy, crying jags, loss of motivation, lowering of my ability to focus or stay focused. I did not relate it to the Teva brand, continued on the generic brand, eventually, lost my job 6 months later. Upon losing my health care coverage, I was unable to purchase the medication. Within weeks, my depressive symptoms slowly cleared and I felt better than I had in months, even though I was now dealing with job searching in a very bad job market.

Here is the irony of this whole situation. The job I lost was with Teva, all because of their product, which I felt compelled to use. Talk about messing up someones life on a major scale.

Have been taking Teva Bupropion xl 300mg tablets for 2 years. My pharmacy has switched to Actavis South Bupropion xl 300mg. These pills actually made my jaw bones hurt, depression increased, confused, constipated, could not even finish any tasks. Gained 20 pounds since taking these pills while working out 3 times a week, eating less, no sodas at all. These are not the right pills for me. I am going to contact my pharmacy to find out how to get my prescription changed back to Teva and have my insurance cover it.
I talked to the pharmacist to make sure they had not given me the incorrect medication.

Yes.. I was on watson and then went to actavis and was glad because the other one had a bad smell.. I think around that time I started getting these bad headaches everyday!!I have spent so much money and have no answers. I hope this is answer... Thank you for telling your story.

Sincerely,
Janet T.

I have been taking fluoxetine for a long while (20mg/day) and doing well. My pharmacy @ Kaiser switched to Teva brand of fluoxetine and I have been experiencing what I call "breakthrough irritability" and feeling uneasy and antsy and felt like my old negativity was returning. After speaking with a friend who used to be a pharmacy tech she explained that health care companies sometimes switch manufacturers as they bid less. So I have called Kaiser and they are willing to "send out for a special order" for me to get my previous generic company for fluoxetine.

Then, I found this site and I understand. Part of me wonders if it is in my head as I read some blogs on here and some people actually prefer Teva over another company??? What gives?? How might I get this Teva fluox. checked out to see if it is "live or memorex"???!!!!!! Thank you~BW

Have taken brand Wellbutrin XL for 7 years - have just got my first teaching job out of college, and have found out that my insurance will not pay for brand name Wellbutrin - no way/no how - no matter what the doctor says/does/appeals - it is $575 for 3 months - I cannot afford it, and cannot take generic.

Anyone else in this situation, and how did you handle it - switch to generic SR? Order from Canada? So upset over this...

I had the same experience with Medco mail order pharmacy, which my insurance requires me to use for maintenance drugs to be covered. I called Medco and they told me they will continue to ask my doctor to switch me to generic Wellbutrin, despite the fact that it caused rapid heartbeat severe enough to put me in the hospital.

Their typical procedure is to fax an "authorization form" to the doctor's office, which looks suspiciously like a refill request, but in tiny print at the bottom it says it authorizes them to switch to generic. It's ridiculous - my doctor's office showed it to me. Fortunately, my doctor has instituted a policy of refusing to deal in any way with Medco, by phone or fax, and will only issue paper prescriptions to be mailed to them.

It's a little less convenient but it's worth it to know they won't be able to trick my doctor's office into switching me to generic, then mail me three months worth, charge me for it, and refuse to accept a return. I did tell Medco to be sure to make a note in my file that I asked them not to attempt to switch me to generic, because I was making notes and that I am an attorney and would be happy to sue them if they do it again.

I have been taking the Barr brand of Prozac for many years but the last time I needed a refill the pharmacist informed me that this brand is no longer available and gave me the Teva brand. It's only been two days and I'm feeling irritable and depressed again. Is this all in my head or are others experiencing the same thing? How can I obtain the Barr brand or is it no longer even being made? PLEASE HELP!

I have the same experience with Wellbutrin XL, the medical aid will not pay for it. My doc is busy sending a motivation for it be chronic medication.

My pharmacy recently switched manufacturers for generic fluoxetine. My 11 year old son and I have both been doing well on the Sandoz brand. His last 6 weeks meds have come from Teva. He and I have noticed a definite difference in His mood. Calling all over trying to find the Sandoz brand with no luck.

The insurance company says I can pay $500 a mo. for the name brand, and that's just for his prescription. I'll be completely broke if I have to switch mine too. This is so frustrating! The pharmacy treats you like your literally crazy if you suggest the new generic is not working. If they only knew how much time, money, Dr's and tears it took to get my son on track. There is a definite ignorance or denial about generics. Glad I found this website!

My insurance company, MEDCO, will charge me about $385 for 30 days worth of Wellbutrin 300 XL. I can't afford it. They charge me 15 or 20 for Buproprion XL. I have been taking this for about 8 months. Since the beginning, I have felt like my throat is tight, I have a cough constantly, I have developed itchy skin, and my chest is very uncomfortable, pressure & achy, much of the time during the late day as more of the drug gets in my system.

The longer I'm on it, the worse I feel. I'm going to tell my psychiatrist I need to get off this stuff.

Caremark pharmacy changed my prescription also. My doctor wrote brand name required for Prozac. I just received fluexetine instead. The customer service person said they had called and received verbal authorization to substitute the generic. I was furious.

I wasn't notified, have tried 3 times to take a generic form, and went back into a depression. That's why my doctor wrote brand name medically necessary on the mail order form. This is the mail order pharmacy practicing medicine in the interest of money.

My sister's insurance ended so she settled for generic effexor. 2 weeks later she shot herself in the head. She was very aware of the 2 week time period for many med change effects to hit. She felt it happening, spoke to a close friend about her concern and stayed home from work (unheard of) 2 days later she was found in her locked apartment with a suicide note. Dead.

I was nearing functional life after 8 years on wellbutrin xl. For about 2 years I've practically lived in bed. Looking back, I'm fairly certain that's when my pharmacy started dispensing the generic that was called budeprion. Now I get the one called bupropion, which is possibly the least effective for me. Time to insist on brand name.

I have been taking brand name WELLBUTRIN SR 150MG FOR 8 YEARS. I can not take the generic brand. It does not have the same effect that the brand name does. I am taking it for depression and anxiety. While employed my insurance co-pay was 50.00. When I retired this year and went on Social Security, my coverage for the name brand Wellbutrin is not covered. For your infor it is under AARP (United Healthcare). United Healthcare was the name of the insurance co. at my place of employment. They filled it one time only. at $86.00.

I received a letter from AARP (United Health care claiming that the FDA did not say it was for depression or anxiety. It is to help people quit smoking. Well, I do not smoke and it is the only medication that has kept me sane. Also said that they would pay for the generic. It just doesn't make a lot of sense.

The Company that makes the Name Brand Wellburtin should get together with the FDA and explain what other uses this great medication can be used for. Also, My Doctor that prescribes my medication called my insurance Co. and also wrote a letter and they just ignored everything and said what they could do. Now I have found a pharmacy that I can get it for $112.00 for a 30 day supply.

I had to cut out most of my medications so I could remain on the name brand wellbutrin. It is not fair to have to pay out of pocket that much on a fixed income. Please, please get with the FDA and bring your medication up-to-date.

I had the same thing happen in Feb 2010. I was originally on Wellbutrin SR 150. But what I thought was a generic form, was actually a brand pill, sold under generic label. It had been a big white pill with black lettering. Smooth coated. It worked very well. Then suddenly I receive a purple pill. It was horrible. Crying jags, sever thoughts, symptoms I never had except when in my initial trauma.

I researched and discovered that GLAXO SMITH KLINE had ORIGINALLY sold their own brand name to the Watson. Watson was not at the time manufacturing their own pill. I HAD receive a brand name drug for $60 a month! I was lucky. Then When GSK stopped selling their product to Watson, Watson manufactured their generics. SO THE PURPLE WATSON made me very sick.

I quit meds altogether until I got worse. Then again, my doctor put me on Brand only, and I bought it in Canada for $90 a month. It is $240 a month in US. (I don't have insurance). After many months of this, I got a bottle that made me feel sick. I swore it felt wrong, they swore it was brand. So I switched to the American bottle. Same thing. A few months ok, now this bottle feels weird. Clutching feeling in throat, like a nicotine withdrawal. In conclusion I think even the BRAND GSK has quality control issues with the coating.

If the generic companies can make a product like Wellbutrin XL and sell it at a reasonable price; why can't the company that makes the brand name product reduce their price? If the true Wellbutrin XL was less expensive they would sell much more and probably come out ahead in the end.

They have the Sandoz brand at my Target. It is the only one I can take. If they are out of it they will find it for you (I'm in Houston).

I have been on Welbutrin XL for a couple years now with excellent results. The pharmacy filled my prescription with the generic drug and within a couple of weeks my symptoms had returned and the medication was of no benefit in treating my depression.
I recently changed insurance coverages and the insurance company now has refused to pay for the name brand due to the availability of the generic formulation of the medication. I and my doctor have provided documentation supporting my claim against the generic, but to no avail. To me, it is of no benefit for the patient if the medication is available to treat an illness but the price is so expensive that it makes treatment cost prohibitive.

I have to say named brand like PROZAC is way better for me then generic types I have tried. I have to be on Prozac it works great for me and others check it out.

Well, did the FDA ever complete the human trials on Wellbutrin vs generics? Can't find anything that reports an outcome. What the heck is going on? Does anyone know anything?

I called Medco recently to check on my meds now that we have another insurance company. The mfg of the meds I have been taking since July '08 for depression has been Actavis--Bupropion xl 150 mg. Medco only had records available since Feb '10 which had Actavis listed on bottle as the mfg.(I have never been on the name brand-Wellbrutin xl so I can't give any comments). My concern now is this---new insurance company has NEW mail in pharmacy and their mfg for my meds is Global.

I'm wondering if anyone has experienced changing 'THESE' mfg for THIS generic prescription? Also, I'm now experiencing more restlessness, unfocused-lack of concentration, unmotivated, irritability & mood swings for about the past 4-5 months. I feel I have ADD bc I've always struggled with remembering things/forgetful! Could this be it? Or do I need to finally up my meds dosage & IF SO, would that help?

Was on Wellbutrin for 2 weeks for bi-polar and anxiety. I felt so much better-had energy, less angry, less depressed, better emotionally overall. Doc put me on Actavis generic bupropion and after 5 days feel have felt lethargic and drugged from day 2, depression is returning and have headaches,am irritable and basically feel worse than when I started. Thank you all who have written-has helped me tremendously. Will call doc. on Monday to see if I can go back on Wellbutrin. Will keep my fingers crossed.

The Teva brand of Welbutrin sent me to the hospital thinking I was having a heart attack the anxiety was so severe. Long story short, the doctors didn't even realize what the cause was. I realized after having to fill my prescription while out of town, at Walgreen's, they gave me the Teva brand instead of the Watson brand. I had never even heard of Teva before this incident.

Now, I am taking prozac, and realized when picking up my 20 mg instead of 10 mg, that my pill was in a capsule form. I talked to the pharmacist and she told me it was Teva brand. I will be taking my first pill tomorrow. Wish me luck.

I am unable to take the generic form of Wellbutrin XL 150mg and am struggling to pay the $200 a month for brand name that I know works for me. In desperation, I ordered a 3 month "name brand" supply from a Canadian Pharmacy. The pharmacist I spoke to assured me they were name brand, and the fact that the stamp on the little white pill was different and now said GS5FV was due to it being manufactured in Turkey. I have been taking it for 3 weeks and am not doing well. I am irritable, dizzy, restless, unable to focus, lethargic, experiencing daily headaches, heart racing, and problems with my sinuses. I am ready to go off completely, but know this is not the answer. I am at my wits end, preparing to battle with insurance and already feeling like I'm losing. What else is there to do?

I've been on generic Wellbutrin for several years, and having read all of the other comments, believe that I was getting the name drug marketed as the generic. This month my pharmacy (Target) switched to Actavis. I've had chest pains that made me think I was going to have a heart attack, then my hands started to get shaky. Not good, as I'm a jeweler, and now the chest pains are more or less gone, but I'm so dizzy and jittery I can barely function.

I didn't put two and two together until I forgot to take it yesterday, and felt fine all day. Woke up with the usual withdrawal if I forget a dose, took a pill and am shakier than ever. I'm calling the pharmacy tomorrow to see if I can switch back. I'm sure my insurance won't cover the name drug. Not that I wish bad things on anyone, I'm glad to see that I'm not alone, and that it's not all in my head. Well, technically it is.

Yes, Actavis drugs are much superior. Any drug I have taken by Teva has never worked. On WB XL Actavis, I am much more alert, feel like myself, productive.
I also switched to Actavis Klonopin, because Teva, once again, only gave me a headache. I took the Actavis brand and I felt warm, dreamy and not a care in the world.

The bad news, as of April 2012, Watson purchased Actavis, sale to be final by end of year. I don't know if they will keep Actavis superior formulations, or consolidate, and the quality of Actavis will be a thing of the past.

Actavis was a private company, they should have held out and did their own IPO.
They are releasing their own BRAND NAME pain reliever in June, this is unheard of for generic companies. This is the level of quality and research that goes into their generics. I pray Watson does not kill Actavis innovation.

The FDA and Teva have come up with a plan to compare blood levels achieved with the generic antidepressant to those with the brand-name drug. Teva intends that this study will reassure people that anecdotes like yours are unrelated to its generic product.

Teva FAIL - FDA withdraws Teva's generic Wellbutrin XL300. The formulation dumps too much drug into the system too quickly, defeating the benefit of sustained release. This is really a critical finding - it's not just a matter of synthesizing a molecule and wrapping it in a generic time release formulation. Timing matters and now the 'anecdotes' are supported by experimental evidence. Sadly, this took years of work and FDA money to conclude what patients had experienced in the first months of release. I'd like to think this will bring more legitimacy to patient experience with generic:brand, but in the end, it's about insurance providers paying less for what SHOULD be an equivalent drug. Maybe - just maybe - the FDA will revise the guidelines for generics. Guess we'll see what the future holds for biosimilars!

when I first started on Welbutron 300 it was great, then came generic, wow a, lot cheaper. Until I found this site, suddenly realize these periods of feeling like being on a roller-coaster may not be just me, so have bit the bullet and bought name brand, maybe it will answer some questions.

A neuropsychologist has diagnosed me with "ADHD and Depression" about a year and half ago. I am nursing school and have recently tried a couple of stimulant medications. Adderall worked well, most days in the beginning. It did make me incredibly sleepy, until I took about a third of my prescribed dose. Time went on and it, frankly, made me depressed as Hell (on top of Nursing school stress and the monster teachers that seem to be associated with it all - but that's a different website!) So, after two more unsuccessful tries on different stimulants, I'm back on Prozac. I have decided to go with brand name (with a printed coupon from the web, I was able to get it at 218, instead of 284 - I do not have insurance).

I did this because years ago I was on it before there was generic and it helped me tremendously (other than some sexual side effects). I have been on the generic and I don't know if it wasn't as good as the brand name because the drug "pooped out" or because generic is just junk. We will see..... anyone have any suggestions of what generic name works, rather than what generic name doesn't? It's insane students have to take out extra student loans to pay for medication.

I have been on generic Prozac for several yrs. the Manufacturer is
Sandoz. The pharmacy switched to the Teva generic once. I found
It ineffective and asked them to order the Sandoz generic instead.
Good luck to you. Hope this helps.

I have not heard of Sandoz, thank you for your help! There is another company I have read about that seems to get thumbs up - I can't remember the name, but it was along the lines of North- something. I once read someone's blog- comment about taking generics with warm water and how it can promote proper 'absorption". For what it's worth, I could possibly see something to do that, given the variation of ingredients/fillers used.

Oh my.. how this country has changed in just 10 years. The left hand doesn't know what the right's doing, S.S. is not 'ours' and our pre-school teachers are being equipped with .357's -- I find "People's Pharmacy" website comforting.

I started taking Bupropion XL 150 mg tablet in September for 2 weeks and felt worse so my Dr. increased dosage to 300 mg tablet and I felt much better. I have been taking the 300mg tablet for 4 months now and my depression is worse then it has ever been. The first manufacturer of the 150mg looks to be Global from Costco.

My 300mg XL was from Actavis and now Costco has changed to Watson and I am getting ready to start my new script. I don't know if I should stay with this medication from a new manufacturer and hope I improve ?? Does anyone have any experience with this to share? Thanks

I was severely depressed and actually on the verge of suicide 3 years ago and my therapist of 1 year suggested Wellbuterin. I could not afford the name brand so I got Actavis buproptoan SR 150mg and I can tell you this: IT SAVED MY LIFE> I noticed a clear difference the very first day. My memory became sharper, it was easier to chat with new people, I felt motivated-creative-happy. After 6 months on 150mg a day I noticed significant hair loss. My life was much better by then and so I stopped my dosage and did just fine. About a year later my depression returned a little and as a proactive measure I went back on buproprion only the pharmacy gave me Santos (purple pill). That stuff didn't work and made me itch like crazy all over my body. So I quit it. I am back on Actavis and plan on being on it for about 2 months so I don't see hair loss just long enough to get through the down cycle I experience once a year. I have read a lot and I think what people need to consider is that everyone reacts differently to each generic brand of any drug. So if something isn't working for you try the other generic brand by switching pharmacies- call around- do your research- and get what you need. I think you should be able to tell IMMEDIATELY if it is working or not.

I have been on brand Wellbutrin 300mg XL and then the Watson generic for past 12 years. Last month when the pharmacy filled it they said nothing, I noticed it looked different but thought nothing of it. The first day I took the new brand I was dizzy, jittery, agitated. Basically all the things I experienced when I first took this. I have been on the new brand, Actavis, for a month and nothing has changed, in fact I've had to up my Klonopin to counteract it. I am distressed to see that Watson and Actavis merged and they pulled the Watson version, because this is awful, and apparently the effects are very noticeable.

Having been on generic Wellbutrin for years, I've found Sandoz and Watson to be the least horrible. I won't say best. But now it appears those brands are no more...My pharmacy is good about ordering the brand I request, something Medico would not do.

Hospitalized last week, I was given a bupropion that did not cause nausea like my usual pill. With a little detective work it turns out to be Actavis.!!

My doctor also changed my rx to the XL version. He said the coating is thicker and that may make it less likely to cause nausea. The nausea (and vomiting) are so bad, that on days I won't have IMMEDIATE access to some crackers, I don't take the pill.

Good luck everyone. We have to keep fighting the insurance companies and big pharma to protect our health. They sure aren't doing a decent job.

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