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Blocking Stomach Acid Increases Risk of Hip Fracture

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People who take acid-suppressing drugs appear more susceptible to hip fractures. Scientists at Kaiser Permanente compared data from nearly 40,000 patients taking drugs like Prevacid or Zantac to 130,000 records of patients not taking heartburn medicine. After just two years on the medications, people were at greater risk of breaking a hip. Previous studies had implicated long-term use of proton-pump inhibitors like Nexium, Prevacid or Prilosec. This is the first study to show a danger from short-term use or older acid-blocking drugs like Pepcid, Tagamet or Zantac. Those on the highest doses had the greatest risk, with people in their 50s showing the greatest increase in fractures.

[Digestive Diseases Week annual meeting, Chicago, 2009]

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5 Comments

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I have had asthma since I was 3 yo. I have also taken corticosteroids & other asthma drugs my entire life. I have been on ranitidine (zantac) since 2002 because of reflux from the asthma meds.

I have recently had a very severe shattered distal radius & possible druj displacement. I'm going to have my 3rd surgery in 5 months on 06/23/09.

I also have a right hip & knee problem due to avn.

could rantidine (zantac) have caused or weakened the bones and made them fracture more easily?

I have been diagnosed with a hiatal hernia and GERD. My gastroenterologist put me on Nexium, and when I asked him about the connection between Nexium and fractures, he told me that previous studies were flawed.

So I filled the prescription for the generic form of Nexium. I also have osteopenia and am on the generic form of Fosamax. I've tried all the prevention measures such as elevating the head of the bed, not overeating and have ~ 20 pounds yet to lose. Is there anything else so I can stop taking the Nexium? As I understand it, I should not stop it abruptly. Thanks.

There is a natural way to ward off heart burn and acid reflux. I take aloe vera 80 gel twice a day. I have taken nexium and other acid blocking drugs all have caused hip pain within one week of use, until I started taking aloe vera 80 gel. try it

I understand your condition. You should practice Yoga. It will definitely help. I have been practicing for past 6 years and I do not take acid reducing medicines anymore.

Nexium has caused considerable damage to my life. I am a 40 year old male, 6", 165lbs and previously in great physical shape other than moderate acid reflux for which I was prescribed Nexium. I was kept on this drug for 10 years by two different doctors as it was effective in treating the reflux. At a routine executive physical, a third doctor decided I should have a bone density scan which revealed Osteopenia bordering on Osteoporosis in my back and hips.

These conditions do not run anywhere in my family, not even for my grandmothers and are the result of prolonged use of Nexium. There were no PPI fracture warnings back then and even once there were warnings, one doctor told me "You are young and male so you do not need to worry about this".

Now I use a half teaspoon of baking soda mixed with water when I experience reflux and it works. I learned all of this the hard way and will suffer for the rest of my life because I used Nexium.

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