Q. I have taken both lithium and Wellbutrin for 15 years to control bipolar disease. Recently I have become very thirsty. It is most noticeable when I'm speaking to large groups. (This is part of my job that hasn't changed for more than 25 years.)
My doctor says thirst has always been a possible side effect of both medications. Is there anything I can take to relieve the thirst, even if only for the periodic speaking engagements?
A. The antidepressant Wellbutrin (bupropion) can cause dry mouth. Real thirst, though, is a common side effect of lithium. The fact that you are bothered with thirst now although it has not been a problem for years might suggest you are more susceptible to the drug. Perhaps your kidneys are not coping with it as well. We recommend you see your doctor for a thorough check-up and blood test to make sure the dose of your lithium medication is still right for you.
