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Can ACE Inhibitors Cause Constant Coughing?

Q. I have had a violent cough for several months and have been treated with four different medications, a chest x-ray and blood test, all to no avail. I started taking lisinopril about the time this all began and noted that a cough was one of the side effects. When I asked my doctor, though, I was told that the drug was not the cause.

I have not been able to get restful sleep because of the constant coughing. Have you ever heard of such a reaction to this medication?

A. ACE inhibitors (benazepril, captopril, enalapril, fosinopril, lisinopril, quinapril and ramipril) are prescribed to lower blood pressure. They’re very effective and usually well tolerated.

A persistent cough that doesn’t respond to cough medicine is a common complication, however. One study from South Korea found that a daily iron supplement, ferrous sulfate, may help ease this symptom (Hypertension, Aug. 2001). If not, your doctor might consider a different blood pressure drug.

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About the Author
Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. His best-selling book, The People’s Pharmacy, was published in 1976 and led to a syndicated newspaper column, syndicated public radio show and web site. In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”.
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