a bottle of budeprion xl 300mg

Q. I have taken Wellbutrin XL for two years and it has taken care of my depression beautifully. In January my insurance company switched me to the generic called Budeprion XL. I didn’t think twice about it. I just assumed it was as good as Wellbutrin XL.

After a few months thinking I was losing my mind and that Wellbutrin just wasn’t working anymore, it finally dawned on me that I was no longer taking WELLBUTRIN! (I honestly hadn’t even thought about the generic.)

I have been very depressed, crying and irritable with no energy or ambition. While I am not suicidal, it sure doesn’t sound like a bad plan most days. I will stop Budeprion XL immediately even though I will have to pay full price for Wellbutrin XL.

A. More than a dozen people have contacted us regarding experiences strikingly similar to yours. Some of them reported nausea or dizziness as side effects of Budeprion XL; all of them said their symptoms of depression had returned.

We have no scientific evidence that there is a difference between the brand name and the generic. Nevertheless, so many reports convince us that there should be an investigation.

We have arranged with the FDA to analyze any generic pills that readers of The People’s Pharmacy suspect are not equivalent to their branded counterparts. Please describe your experience and send your generic pills with as much information as possible: Name of medication, name of generic drug maker, lot number and date dispensed. (Data may be available from the pharmacy.) Send the parcel to Graedons’ People’s Pharmacy; PO Box 52027; Durham, NC 27717-2027.

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  1. Elaine

    I was put on Wellbutrin (bupropion) 150sr 2 times a day about 5 weeks ago. The 1st “batch” was ok for about 3 weeks, it was a round blue pill (I don’t remember the manufacturer). Then I started feeling like I was crawling out of my skin. Always anxious. I just wanted to run away as fast as I could. I thought maybe it was because I was going off the Lexapro at the same time. I refilled my prescription and got ( round white pill “Sun P 737” imprinted on it). I live in a very remote area and only1 pharmacy, so I came home, got on the computer to make sure it was Bupropion. It was. I started taking it and thought again I was going to crawl out of my skin. My legs wouldn’t stop moving, and once again, wanting to just run as fas as I could, to who knows where. I started searching the web and found that bupropion causes extreme anxiety! I already have anxiety, and take Xanax for it. I completely stopped taking the bupropion today, but still have the restless feelings in my legs. I guess I will just have to take my Xanax until I can see my dr. again, which is over 200 miles away. I feel like I am just stuck and don’t know what to do! Anyone else have these problems? HELP!!!

  2. alexia
    hondo tx

    My local Walmart pharmacy changed my welbutrin generic from a pale blue pill to a new smaller pink pill marked APO on one side and BUP 100 on the other. The pills seem to be markedly less effective and are very fragile. I am looking for an alternative generic option to this medication or see if my insurance will cover the name brand. Has anybody else had this experience?

    • Billy

      I just started taking the same generic. It’s from a company called Apotex. I was reading about how the FDA has warned Apotex a few times about manufacturing issues. I saw it in a WSJ blog. Since taking it, I don’t really feel any affects compared to when I took the name-brand Wellbutrin years ago. That’s why I started researching. I’ve heard that a lot of generic versions of Wellbutrin were not equivalent. I am going to see if I can get on the real stuff and get away from these type of companies that probably only sell “filler” and not even an equivalent to the intended drug. Even at the generic price, they must be laughing all the way to the bank.

      I have NO faith in the FDA. Seems like just another place for friends of friends to collect a government paycheck it seems.

  3. Lisa
    South Carolina

    I had the same experience. The generic form of Wellbutrin does NOT work for me at all. It had the opposite effect that it is supposed to. I thought I was losing my mind. I wish they would make a better quality Wellbutrin. I was able to take the name brand for a while, but now, since the generic doesn’t work, I am going to have to find another anti-depressant. Maybe that’s what Wellbutrin wants because the generic certainly doesn’t match the name brand ineffectiveness. It is terrible.

  4. mlabbie1
    United States

    I too am taking generic wellbutrin sr 150 mg once a day in the morning. I am astounded at all the alike side effects the everyone is having. I am experiencing a severe need to satisfy something so I am eating non stop because I can’t satisfy the hunger. I am also having ear ringing, anxiety, panic attacks, newly found social anxiety, fast weight gain, chain smoking because I can’t get the satisfying feeling of having a cigarette, insomnia, and a jittery feelings off and on, and slight shaking. I was hoping this would help with anxiety, smoking and an overall sense of well being. I have been Taking it for 2 weeks now and have tried to ride out the side effects. Today I asked my doctor for a prescription for the brand name only. Fingers crossed cause if this is how the generics are, I don’t want them.

  5. MissKyle

    I finally found you! I swore one of my problems with ‘Wellbutrin’ before was weight gain, despite the doctor insisting that is not a side effect. I was put back on (Bupropion HCL SR 150) a little while ago. (as someone else mentioned, plumb colored pill). And the same, but 100 (small blue) to take at lunch time.
    I am gaining weight and retaining more water than ever.
    This is not in my head, and as everyone is a little different, just because it causes weight loss generally, that is not the case for me. I am going off of it, because the weight gain and discomfort with water retention, is causing more misery than the subject in my life I am dealing with. I will not fit in my clothes this summer, and as it is, am narrowed down to very little in my closet. I have increased my exercise and watch my food. The only difference is the Bupropion. Buh-bye. Not acceptable. Guess I will talk to the doc, because it’s no longer an option. I’ll have to go off, and make sure to keep exercise a priority to release endorphins… because what’s happened to me in the past 3 months doesn’t make sense. Other than that. So frustrated! Thanks people, at least I feel validated, and not like I’m losing my mind.

    • MissKyle

      Oh, AND the ringing in my ears. I wondered what that was, because it’s all the time.

  6. Alice
    denver, co

    I’ve been on Bupropion XL 300 mg MFG – Zydus. Round white pill with number 354 for three plus years. My issue is terrible weight gain, bloating this past year. Is there any information that someone can share if this particular generic pill causes weight gain Please. . I am More depressed over this than anything. ..
    I’m so glad I found this page. Thank you.

    • Paul

      I am also taking Bupropion XL 300 by Zydus for a while now. I cannot lose weight in any shape or form even though I train really hard, and I mean really train. It is the most bizarre thing.
      Do we have any information on this version of the drug, Bupropion XL 300 by Zydus?

      I am also taking it with Venlafaxnie ER 37.5 by Teva. I was told that is a very common combination.

    • Linzi

      These were the exact side effects I had with the Zydus brand of bupropion “wellbutrin.”

    • Sarah

      Gezz Ive gained like 5 pounds in 20 days, I am also taking 300 generic zyban “aka fat pill” I was on buprophin 150 and didnt have weight gain, I saw all these things about people loosing weight and I didnt feel the 150 doing much so I asked to be upped tp 300 and things have gotten worse. I still feel no different, only good thing is no more daily crying. The bad thing is I thought if I upped the dosage I would loose a few pounds but Ive actually GAINED, and ive done nothing different. Ive actually eaten less and am drinking more water. This is crazy, Im gonna try to switch to brand and see what happens.

      • Sarah

        FREE 0 COPAY! So I went on the Wellbutrin website and got the link to Direct Success Pharmacy. They are shipping my FREE Wellbutrin today! My insurance company told me it would be $1400 for the same amount. Im not kidding, I called , spoke to a real person; they quoted my Blue Cross policy, then switched my script, and its in the mail today! I can’t wait. All these phone calls to pharmacies and research on generics. I’m excited to see how the brand name works!

  7. Tommy S.
    Mount Vernon, VA

    I have been taking the brand name Wellbutrin 300mg XL. This past refill, I was switched to Bupropion 300mg XL generic version. It’s an oblong pill. Much like everyone else, I figured it wouldn’t be a problem. I couldn’t have been more wrong! Within a week, I started feeling horrible if not even more depressed than before I started taking it. I consistently had an upset stomach, and have experienced anxiety like I never have before. I was even having palpitations which caused me to think I was having a cardiac event. I also noticed I have become very anxious and distrustful (almost to the point of hypersensitivity). These are issues I have never had. I thought I was going crazy. I couldn’t understand how, when switching to Wellbutrin XL from Zoloft, I had never felt better. I was also kind of excited that there would be no sexual side effects (negative anyways) and had some weight loss benefit (I gained about 50lbs taking Zoloft and it literally tanked my sex drive and I’m in my early 30’s with 5 kids, you can do the math!). Like I said, as soon as I switched to the generic, it was like my train derailed off the train tracks. I know that there has been tests for bioequivilency with the Budpropion, but has this been done yet with the Buproprion? What’s worse is, I went to Rite Aid to get the brand name and the pharmacist said the brand name is no longer available. This can be right! How in the world could the manufacture stop making the brand name when there has been so many problems with the generic version? What can I do?

  8. Janelle
    United States

    I have taken the name brand, Wellbutrin XL 150mg twice a day for over 3 years. My insurance made me switch, because I cannot even begin to afford the name brand, to the generic. The first generic I received was: Bupropion Hcl Xl Tabs 150mg Manufacturer: Global/Impax Marking 681 Oval Yellow Tab Er 2411. This stuff SMELLS horrible, and after taking for a couple of weeks CLEARLY DIDN’T WORK. I was very depressed, with lack of desire for activity and lots of crying!

    After telling the doctor, she switched me to another generic: Bupropion Hcl Sr Tabs 150mg – Manufacturer Epic/Sandoz Marking E415 Round Plum Tablet Er. This one seemed to help with the despair and loss of hope, but now I have a high pitched ringing or a constant sounding buzz.

    Since switching from the name brand, to the generics, I have gained 40 pounds and have gone through roller coaster ride after ride with my emotions! I even started going to counseling once a week, because of the severity of my depression! I feel like I am a blue collar guinea pig, without recourse, and my life and the lives of those that love me are pointless to those who have plenty of money!

    • The People's Pharmacy


      Your story sounds reminiscent of hundreds of stories we received from people who were switched from Wellbutrin XL 300 to Budeprion XL 300 or another generic bupropion slow-release product.

      We spoke with the chemist who was most knowledgeable about Wellbutrin. He told us flat out that a bad smell was indicative of manufacturing problems and chemical breakdown.

      We have repeatedly badgered the FDA about the bioequivalence of generic bupropion XL 150 products. We have looked at the curves and we are as concerned about this product as we were about generic Budeprion XL 300.

      As you may know, our efforts finally led the FDA to test Budeprion XL 300 and determine that it was NOT bioequivalent to Wellbutrin XL 300. The generic drug was eventually pulled from the market.

      That is not the case with bupropion XL 150 generic products. We will keep advocating for people like you who deserve generic medicine that is absolutely identical to the brand name. At this time we cannot guarantee that is the case. It is incredibly frustrating.

      • Merry
        starkville ms

        I have been taking bupropn HCL 150 mg off and on for quite some time now, and I have contacted a skin rash that itch and burns like fire, I have yet to speak to my doctor about it but I will eventually will. so as of now I have stop taking it so to speak can someone please tell me I am not alone in this and is there something else out there more natural and much less side effects than what I am dealing with now.

      • Crystal
        Little Rock, AR

        I have been taking the generic brand of Wellbutrin 150mg for some time.
        Lately I have been so depressed that I can’t get out of bed. My disposition toward everyone is all negative and I feel so bad I can hardly put 1 foot in front of the othr
        I decided to look at my bottle for generic description and compared to last one only to find out they are different. So it does have a negative impact. I’m not sure I’df I wouldn’t feel better if I don’t take at all. This is so bad!!!!
        The new generic prescription is a plain white pill and called– actavis and the other MFG for Bupropion 150mg is Anchen generic for Wellbutrin 150mg.

      • G

        Wow, I thought it was me and/or my situation. I have tried Effexor and lexapro with horrible results- instant weight gain and those horrible leg zaps when switching over. Wellbutrin was my salvation. Now that I am on the generic I do notice a change. When I first received a generic, I could not take it. I went from xl to sr and visa versa, and finally found one I could use. I take it with Buspar for anxiety. Lately I have felt overwhelmed.

        The generic is not working, I am depressed, anxious, and just feel frazzled. I am bloated and nauseous, as well as feeling light headed or off balance at times. I asked my Dr. if the weight gain could be from the meds and of course was told not with Wellbutrin. I am so glad I found this blog. I have gained over 25 lbs, my cholesterol keeps creeping up and my dr. wants me to go on a statin. I’m being told about lifestyle changes and eating right- which I do! If hot, I sweat profusely. Soaking wet, dripping. Yes it is hot in Florida, but this is not normal for me! I never thought it could be the meds, but it makes sense. I don’t know what to do. I am petrified to stop taking it. I tried once and had palpitations and actual chest pains not to mention the depression. I have some older leftover pills and I am going to try them. If there is a change I guess I have to try and convince my dr.

    • Betsy
      United States

      I was given the generic 150 sr instead of 150 xl I just thought the xl had changed colors but soon the ears ringing and headaches resulting. I felt dizzy and I fainted and then my knee gave out my question are joints effected by generic sl? It’s sad because I’d been doing so well and feel like a guinea pig, too. Or one they just don’t care about

  9. bree

    I can’t even believe these stories are so similar to mine except that mine is also having trust issues right now (and horribly worsening). So I got on wellbutrin back in 2008 for quitting smoking and had taken it for about a month. It worked but I also liked to drink and it says would cause seizures so didn’t drink for that month until my b-day was just a few days away and decided to get off it even though it helped with my irritability i wanted a drink. had a blast and never started the script back up until recently now 2014. I’ve been taking bupropion sr150 for about 7 months but let me back up a step, I also found the love of my life 5 years ago and sober together since day one got married a year ago and this January 2nd we will have not smoked for three yrs. Things are great except I started getting a little irritable and thought maybe I try this again. Thats where bupropion comes in. I’ve gotten to the point where I wanna leave my husband and move back to my moms who lives in another state becauseIi think he is cheating and I know in my heart he isn’t I’ve known him for 22 yrs. We were old drinking buddies best friends. He has gotten to the point that he is afraid to call throughout the day to say hi for fear that I’m gonna rip his head off on jealousness (where you at why you calling when you getting off work etc…) it saddens me and not to mention that I’m peeing constantly along with panic attacks like I’m tweaking, headaches, spacing out, the list goes on. We’ve been trying to figure out what is causing this cause we never argue ever and today I blew up and just wanted to leave him i thought i was gonna just go off the freakin wall. he once again took off down to the shop and for some reason started crying and got on the computer. I’m not sure why i decided to look up this site but boy am i sure glad I did. I’m not taking this medication again. I told my husband I’m done I don’t know if I will have side affects from winging myself off but I told him it’s gotta be better than feeling like this!

    • Rhonda
      pleasant grove al

      I’m taking 150 Sr twice a day it makes me sick nausea all day . I have to get my doctor to appeal telling my insurance why I can’t take generic . so my insurance would pay for brand name now I’m depressed.does anyone know about Mylan

  10. Cynthia

    I do not know for sure but, I developed a full body rash, possibly after insurance switched me to generic. It has been months now. I am working on this horrific disfiguring affliction as I speak; trying to get to bottom of it at a very HIGH cost to myself, physically, emotionally and financially. Anyone have answers?

    • Cynthia

      Ok, here is how I see it, there are so many versions both real and generic of this drug among others that the possibility for allergic reactions are huge. What I have learned is the stuff they use to bind and deliver the medication is usually the problem. It could be gluten, lactose, acacia, talc, you just have no idea WHAT extra goodies you are ingesting and for a gluten/lactose intolerant gal it is a constant struggle! What to do?

  11. Ann

    I have taken Wellbutrin (buproprion) SR 150 mg twice a day for several years (about 7+ years). I take it to stay alert/pay attention and in the past I believe it did help with depression also.

    What is the difference between Wellbutrin and buproprion? What are other alternatives for the same medication or a medication that is very close to this one?

    I lost 2 lb over the summer despite very consistent workouts 4 times a week plus gardening. This med does promote constipation, some dizziness (today for example) and a bit of nausea (today for example). In the past the side effects were minimal/tolerable, and even combatable. Pineapple helps digestion, romaine lettuce eases constipation as well as other veggies. Normally, when I am eating consistently I don’t get dizzy. This morning a banana and a spinach smoothie w/ hemp and chia seeds/almond milk was not enough: I got dizzy after getting up too fast from the leg press.

    I have great reservations about taking a new medicine, but I still need to know what my options are for other medication to stay alert.

  12. nancy

    I took wellbrutrin for the past 7 years. Originally I lost weight and then stabilized at a healthy weight. I work out and run 6 days a week and eat a very healthy diet. recently my company changed insurance companies and the new company refuses to pay for brand name even with dr’s specific prescription. I was forced to change to generic.

    In 2 months I have gained 20lbs on a previous 115lb frame. I have horrible headaches daily. I cannot get to sleep and cannot stay asleep for more than an hr or two at a time. I went from a solid 8hrs a night sleep to 3-4 hrs of tossing and turning. I drink a ton of water and am always bloated even when I eat little to nothing.

    Gaining all this weight while cutting more and more out of my diet and exercising more each day has been awful. I didn’t put the lack of sleep, headaches, bloating and weight gain all together until stumbling upon these posts while unable to sleep again tonight. I feel that on wellbrutin I actually slept better, had more energy, could focus and felt healthy. Since changing to generic I have been a mess and haven’t understood the cause. I am stopping immediately to see if some of these symptoms improve—- frankly I would rather be depressed and get a good night’s sleep than live like this one more day. I pray dropping this generic drug helps. It is ridiculous that greedy insurance companies can override doctors and that wellbutrin brand name is cost prohibitive.

    I feel at least a little better that perhaps I am not crazy and others have had the same experience. I literally feel sick every day from the bloating and weight gain from this drug.

  13. Andra
    United States

    I am on 300 mg of the generic Wellbutrin XL. In two out of my last 5 refills of the drug (I’ve been on it nearly a year, Advantis has been the manufacturer throughout), the drug has been ineffective. I’m in a “bad” batch right now; the last time this happened (about 3 months ago) I got progressively depressed, but had all of my energy back within a couple of days of starting the next fill. The pharmacist at Target said everything is the same across these fills – all the numbers, everything, so there’s no way to know if there’s a difference. I’ve contacted my dr asking for a prescription for 2x150mg to see if it will help. I don’t know what else to do except go on the name-brand exclusively, an expensive proposition!

    I can’t find anyone else with this problem, though last time I saw my dr, a few weeks after the first “bad batch” she said another patient had had the same problem. Is there a way to report this? (The pharmacist said not really.) How can I make sure I get the “good” pills not the “bad” ones, if they’re same mfr and everything? Help!

  14. DCG

    Ditto Ditto! I have only been taking generics for a couple month or so but noticed right away that the oblong ones did not work. Now I find out it may be much worse than that. Took an “Activis” generic oblong this morning, felt sick and anxious (almost full blown anxiety attack) within the hour (both unusual for me). Was it breakfast or the med? Now I’m thinking the med. Now it feels like I haven’t taken anything. This Activis brand was NOT recalled by the FDA (!?).
    I’ve also tried a larger round white generic. That one wasn’t useless. Definitely had that kick. I think that was the Watson brand (?).
    I have experience recent pronounced weight gain. Until now I attributed that to work stress….. but in past episodes of overwork I’ve typically lost weight (skipped meals). Now I have another suspect.

  15. DM

    I’ve been taking Wellbutrin for 11 years. I started on it after struggling for a year with severe depression. According to my doctor depression may stay dormant in someone unless it is triggered. In my case a death in the family. He said that most people’s serotonin level will drop when they experience a tragedy, but then it bounces back and you get back to normal. In some people though it never bounces back and you stay in a depressed state, which is what happened to me. Anyway I started on the twice a day brand name and it was great, after a couple of weeks and a few initial days with a major head buzz, I felt like me again. Then, a few years after I started the meds the generic became available and my insurance company switched me over. After about 4 months on the generic I realized I hadn’t been feeling that great. Not as bad as when I was first diagnosed, but still more apathetic and unmotivated than felt right. I was switched back to the brand name and was fine. Last year the co-pay on the brand name twice a day skyrocketed (even with the brand necessary wording), but on the brand name once a day the co-pay was reasonable at $35 so my doctor switched me. I loved it, once a day seemed to regulate far better than twice a day (probably because I wasn’t forgetting the afternoon pill a couple of times a month). Well, my prescription is running out so my doctor called me in a one off refill until I see her next month only when she called it in she forgot to specify brand name so they filled it with the generic. I picked it up and figured I’d just deal thinking, how bad could it be for one month. Well it was bad. After 5 days on this stuff I thought I was going to jump out of my skin. The first day that I took it I noticed an hour or so later than my heart was a little fast and I felt a little amped, but assumed it was just an adjustment to the meds and forgot about being on the generic completely. The next few days I did feel out of it, a bit off, unfocused and unmotivated to do anything other than watch TV which is not me, but I just ignored it. It also took me about two hours to fall asleep on nights 3 and 4 when it usually takes about 20 min. Again, I just thought “well my brain must really be into this TV show”. Day 4 I found myself checking the pollen count because my sinuses were rocking, I had a mild sore throat and felt like a small chest cold was brewing. By day 5 my head felt like it was swimming in a bubble in outer space, I couldn’t focus on anything, I was anxious, my lips were tingling to the point where I wondered if I wasn’t having an allergic reaction to something, my palms were sweating, my ears were buzzing, my head hurt, basically it felt akin to what it feels like right before you have a panic attack except with sinus issues added in. It was horrible. Then all of a sudden I remembered “I’m on the generic Wellbutrin!” I immediately jumped online and found this site along with a bunch of scary articles confirming that yes, all this horrible feeling was a side effect of the Wellbutrin. I stopped taking it and still have some pills from my regular refill that I had saved when I got the generic “just in case” (thank goodness) so I’m off the generic and back on those. I feel mentally more clear, my sinuses are fine and my ears stopped buzzing a couple of hours ago. The generic that I have was manufactured by Anchen which doesn’t seem to be the one most people have issues with, so who knows, but I know that it was def. the meds.
    For those of you who are having issues with getting your insurance to pay if you have your doctor write “brand medically necessary” or whatever wording is required in your state on the prescription the insurance company should honor that. The co-pay will be higher than the generic, but hopefully not astronomically so, mine is a difference of $25.
    Also if you go on the WellbutrinXL website it looks like there are some options to help you get the medication at a more affordable price if the above doesn’t work or is still too costly. I haven’t tried it so I don’t know how insurance cos actually respond, but it would be worth trying at least.
    For the poster who lost 10lbs on the generic. Weight loss is a typical side effect with Wellbutrin, even the brand name that is why it is not recommended for people with eating disorders. It’s great if you’ve been depressed and gained weight as a result, but I guess not good if you’re already skinny. I think the loss of appetite wore off after maybe a year.
    On the subject of urination, both brand name and I guess generic can have this side effect although it is a less common one. When I first started on it I would get the feeling like I had to pee even if I had just, just gone. TMI, but usually if I just went again the sensation would go away. It wore off after a while, I still get it every now and again but not often. On the side effects list it does include more frequent urination, but I’m pretty sure years ago it actually said increased urge to urinate. Which is weird, but whatever, if it means I can get out of bed in the morning.
    I am glad that people are keeping this thread active. It is not only informative, but reassuring especially when you’re in the throes of a generic brand induced anxiety attack (ha-ha) and hopefully this will further the push to get these dangerous generic brands off of the market. Do these pharmaceutical companies give money to the FDA? I can’t understand why they’re so reluctant to pull them off of the shelf.

  16. Lab Lover

    Finally! Someone else having discomfort urinating! I’ve had nothing but problems with the Buproprion. Not only discomfort with urination, but completely unable to urinate! I’ve also had SEVERE constipation, resulting in a blockage in my intestines that was brutal. I never want to go thru that again! So I am weaning off of the stuff!
    I also have experienced lightheadedness when standing,uneven balance/ feeling like I might fall and have ringing in my ears, which I didn’t experience before.
    Initially, the Bupropion seemed to help with my depression, and suicidal thoughts, but I’ve been so sick on it, I’ve lost 10 lbs. that I didn’t need to lose. My Pysch. said to give it more time at my last visit 1 mos. ago. I’ve been on it 4 mos. to 5 mos. I also take Cymbalta, and Neurontin for Chronic Regional Pain Syndrome. The physical pain is still so intense, and the loss of MY life (driving, gardening, traveling, basically everything I care about), which maybe many of you are most likely experiencing as well, has caused suicidal thoughts and one attempt, hence, the Rx for the Wellbutrion XL/Buproprion.
    Has anyone else had issues with constipation/urination. I know it’s an embarrassing topic,but I’d like to take the info.(I won’t copy it/compromise anyone’s identity) I just want to tell him I’m not alone in this.
    Thanks, and so glad I found this site!

  17. AL

    All of those having issues with the switch! Most insurance companies will accept a reason from the doctor to allow you to get out of having to pay for the name brand! Just tell your doctors that you are having these ill effects.

  18. cab

    I am bipolar. I have been taking welbutrin for just over a year. My pharmacist suggested the generic (bupropion xl mylan) as it was cheaper. I agreed happy to save a buck. I was doing so well and then a week into the generic bottle I started getting dizzy. I would be sitting at my desk and all of a sudden get that feeling when you get up to fast. I was irritable, had blurred vision, angry outbursts throwing things, shaking, racing thoughts, suicidal thoughts, I even went back to the pharmacy and asked about what I was going through. They told me it was exactly the same.
    I mentioned to my gp and he said it can be different. I thought nothing of it at the time.
    I would get confused and found it hard to concentrate and then the depression and anxiety kicked in 10 fold. I stayed in the house for almost 2 weeks straight missing work. My social anxiety was back. The worst part was I couldn’t understand why. I had been doing so well. It wasn’t until today when I found this page I finally understood! I’m Not Crazy!!!! I am so relieved.

  19. Erin

    Just wanted to share my experience with generic wellbutrin (bupropion). It’s made by Mylan. I would get a bit of seasonal depression in the fall and winter, and sometimes I was just in a really crappy and negative mood that I couldn’t shake. I have Hypothyroidism and in spite of taking medication for that, I never really got my energy and motivation back fully. But I have a lot of stress in my life and I have taken almost all of the SSRI anti depressants in the past and they all make me sleepy. Wellbutrin was the only one that didn’t have that effect on me.
    A bonus was that it helped suppress my appetite so I wasn’t always craving junk food and I lost 2 or 3 pants sizes. I was able to get out of bed with ease in the morning, exercise, and I was in a great mood… Very happy and fun to be around. I could deal with things better because I was in a better frame of mind. The negativity and crying was gone. It also really increased my sex drive. Wellbutrin was almost a miracle pill, or so I thought. But, with almost any medication, there are side effects. Some you can tolerate and some you cannot. Well, I was one of the people who got the rare side effect of acne…. And I’m not talking about just a few pimples. It was all over my face and my skin was greasy too. The acne was cystic… They were deep pimples that would leave scars and to this day I still have dark spots on my face.
    I felt better until the acne just got out of control and then it began making me depressed. Any benefit I was getting from the medicine was being negated by how upsetting the side effects were for me. I began taking birth control pills (ortho tri cyclen) to try and clear my skin, but it didn’t work. I had topical stuff too. Finally I knew I had to give up the wellbutrin and my acne continued in spite of continuing birth control pills. I switched to ortho tri cyclen lo and that made no improvement. So after 2 rounds of antibiotics this year and finally switching to Microgestin fe 1.5/30 I began to see clearer skin. But I still continued to feel unwell mentally/emotionally.
    I decided to do an experiment. I decided to see of the Microgestin would be enough to keep my skin clear if I took wellbutrin again. The same thing as always happened. I felt better, but within a few days, I was getting acne on my face and in some other strange places that I normally would not break out. My skin also looked and felt greasy. I have also made the connection that wellbutrin makes my scalp itch terribly, especially at night. I thought I had dandruff or a scalp condition, but last week I made the connection when my scalp began to itch after I started the wellbutrin. I am very frustrated because it’s the only medicine that helps me “feel” better, but I cannot accept the side effects of constant acne and an itching scalp.
    I don’t know where to go from here because there are no other medications in the same class as wellbutrin. It’s in a league of its own. I guess I will just have to get by without it or try something completely different. I just wanted people to know that it can definitely cause acne. There is no question about it. Think about it.. Anything that can increase sex drive is surely going to affect your hormones in some way. I think that is what happened to me. The best way to stop it is to get off the stuff ASAP if you notice any skin problems or any other occurrence that is out of the ordinary or bothersome to you.

  20. Mary R.

    Hi there. I took the BuPROPion HCL 300 mg XL for 1 week and it was a horrible experience–instantly I had intense headaches, blurred vision, angry outbursts, and could only sleep 4 hrs. per night…I want the Wellbutrin XL name brand but can’t afford them….hmm may have to consider another AD I hope your experience is better than mine was!

  21. JR

    I used the brand Wellbutrin about 10 years ago and it worked wonders for me and popped my out of the bad funk I had been struggling in. Recently, through a series of personal tragedies I found myself slipping back into that same awful funk, so I went to the Dr. and got another prescription for Wellbutrin. The pharmacy gave me the generic brand and at the time I didn’t think anything of it… well after a week of taking the crap I had so many side affects – dizziness, shakes, cold sweats, blurry vision, super spacey where I couldn’t even finish a sentence, memory loss… it’s been horrible and thought maybe I should have the doctor switch meds for me.
    Thanks for the posts of others users I am now certain that it’s the generic and called the pharmacy to get the real deal, unfortunately they said I would have to have wait 3 three weeks for my insurance to pay for it or pay $330 – grrrr. I wish the FDA would pull this drug. If you’re new to Wellbutrin DO NOT TAKE THE GENERIC.

  22. Assy

    I’ve taken Welbutrin xl 300 for 13 years and in generic form. All of the pills up til now were white and round. I’ve been taking another generic for a week now that is OVAL shaped and white and made by Actavis. I’m so dizzy and sad. Just feel like a turtle wanting to stay in my shell. My vision is almost vignetted.
    Anyone else have this problem with this particular manufacturer?

  23. Matt C.

    Vastly different reactions to anti-depressants are common. Contact your doctor as soon as you can about trying a different medication. I had to go through 5 different ones before we found the right one for me.
    About thought of suicide: Please call someone you trust right now. Talk to them about what you are feeling. They won’t care what time it is or if you are interrupting their favorite TV show. Feelings of hurting yourself can quickly escalate. I found that out the hard way. You can even call the suicide prevention hotline. 1-800-273-8255. They are there to help and understand what you are going through. There is no shame in calling. Please, talk to someone tonight. You have nothing to lose and I’m willing to bet you will benefit from it.

  24. Kayla

    I have the same issue. Nausea and dizziness. I can’t take it! I’ve been taking this for about a month (maybe a week more) and it hasn’t helped one bit. My anxiety and depression are completely out of wack! I’ve never been for suicide. I did think about it slightly when I was on Adderall in sixth grade. I’ve been very against it, but I feel I have been thinking about it more and more. Like what!? I’m nineteen in March I’ll be 20 and I shouldn’t be feeling like this. I really cant stand it. I should be happy and feeling great. The problem is, I’m not.. Help!
    *I haven’t been thinking clearly since I’ve been on it and I’ve noticed. It’s actually scary. A few weeks ago while I was washing my hair in the shower, I was thinking about getting a trim. Yes that’s normal, but that’s not the freaky part. Then I started to think about shaving my head. My hair is down the the top of my pants. I would never shave my head!
    * Another time, I thought about cutting my finger.
    * The first day I took it, that night, I woke up in the middle of the night. At first I thought it was a dream. I felt like something was choking me. I couldn’t breathe. I was trying so hard I get up but I couldn’t. I finally did, and went to my kitchen. Looking frantically everywhere for what, I have no clue. Then I randomly woke up and realized I was in the kitchen and I was looking for my inhaler. Turns out I had a panic attack. Weird because I’ve never had one in my sleep ever before. I have slept walked before, but panicking like that was weird.
    * I haven’t had headaches from this. Thank god! But I have been more irritable than usual. I mean I’m grumpy, but I’ve been way worse.
    Any notes, suggestions, anything please reply to my comment. Thanks.

  25. Kayla

    I have the same issue with Budeprion. Nausea and dizziness. I can’t take it! I’ve been taking this for about a month (maybe a week more) and it hasn’t helped one bit. My anxiety and depression are completely out of wack! I’ve never been for suicide. I did think about it slightly when I was on Adderall in sixth grade. I’ve been very against it, but I feel I have been thinking about it more and more. Like what!? I’m nineteen in March I’ll be 20 and I shouldn’t be feeling like this. I really cant stand it. I should be happy and feeling great. The problem is, I’m not.. Help!

  26. Sympathetic in Portland

    I read your post with sadness but would like to offer encouragement. I also have Hashimoto’s and am taking generic Welbutrin and am going through a divorce with money concerns and Blue Cross Blue Shield (you see why I had to respond! :^) )
    However I would like to say that until this year I also was on Armour thyroid, thinking it was okay, but then my doc insisted I switch (back, after decades) to Levothyroxine. My TSH started at 25 and has gone down to under 5 over the year as she has adjusted the dosage slowly. Things are so much better now — the grey has largely faded from my life and I am much better able to cope with the challenges, with much better energy. You might like to consider asking your doc about other thyroid replacement choices.
    I am taking 300mg a day of the Sandoz generic. I won’t try going off of it until after the divorce. But I can’t help thinking that the main issue for me was the thyroid, not the buproprion. Also I have been going to an exercise class almost daily and I am positive that has also had a huge effect.
    Somewhere in the brain fog and distress is the real you waiting to live a much improved life. Believe me, it is worth hanging in there for, even if sometimes it may not feel like it. Keep working with the docs to find the combination that works. You will be so glad you did and amazed to look back and feel the difference.

  27. ARenee

    I have been suffering with this for years. I have been taking Wellbutrin so many years that I cannot remember when I started. Definitely 10 years plus. I have paid thousands of dollars to take the namebrand. I am on day 2 of generic again because I cannot afford the 407.00 for 30 days namebrand with Blue Cross Blue Shield insurance.
    It’s better for me to go insane. Which is very painful mentally, physically to me and difficult for everyone around me. I was sick with flu like symptoms after one half day of Watson generic. I cant stop crying. I feel like I have a 20 pound brink on my head. The brain zaps are next.
    Unfortunately I am going thru a divorce and have many issues to battle in the next month. I resent ever being prescribed this drug as much as I resent my insurance company robbing me of thousands of dollars. I have to get thru this. I was diagnosed with hashimotos in January 2013. I have been taking 2 grains of armour thyroid for about 6 months. I am trying to eliminate gluten also. I am trying to survive this year.
    I am now wondering if I have been poisoned by this drug resulting in the nodule on my thyroid and my hypothyroid issues as well as the Hashimotos. I believe insurance companies and drug companies are poisoning us. I knew I wasn’t making this up. I cant say that I am happy to see others with an identical issue, but maybe I feel a very small fraction more sane.

  28. Deeboop

    I have been on Wellbutrin SR 150 2x day for 10 years (Its amazing what you all have to say about weight gain, sleep, etc!! I thought for a long time if I took second dose earlier in after noon I would sleep better- XL didn’t work for me) I keep the Brand RX on file (and depending on what color the pharmacy gives me- yellow, white don’t work). Generic changes all the time no matter where I go to fill, but usually Tevo or Watson…… Tevo definitely does not work for me!!
    This time (Fred Meyer) my generics are purple and the manufacturer is EON Labs. Imprint E415
    What the heck? The reason for my search on Wellbutrin today was because I’m wondering what/if binders/gluten are in this antidepressant. I know have leaky gut and need to go off gluten. It dawned on me…. I wonder whats in it? If I’m going that drastic on diet… I don’t want to sabotage my healing by taking a drug that could be the problem. Anyone Gluten sensitive, also?

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