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Nadolol

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Overview

Corgard is known as a beta blocker. That means the drug works in part by blunting the action of adrenaline, the body's natural fight-or-flight chemical.

People normally respond to stressful situations with a rapid pulse, a pounding heart and an increase in blood pressure. Corgard helps block such reactions.

This medicine is normally prescribed for hypertension or chest pain caused by angina.

Although the FDA has not specifically approved its use for other purposes, doctors have prescribed Corgard to treat glaucoma, irregular heart rhythms, tremor, bleeding from the esophagus and performance anxiety such as stage fright.

It has also been used to help prevent migraine headaches. The dose will vary depending upon the condition being treated.

Side Effects and Interactions

Corgard can cause a number of side effects including slow heart rate, cold hands and feet, insomnia, nightmares, blurred vision and sexual difficulties.

Symptoms of nerve tingling, dizziness, nausea, stomach ache, gas, diarrhea, indigestion, rash, arthritis and muscle pain trouble some people.

This medicine may also have a negative effect on cholesterol and other blood fats, so a lipid test before treatment and periodically thereafter would be prudent.

Although Corgard is a little less likely to affect the nervous stystem than certain other drugs in this class, be alert for the beta blocker blahs.

Symptoms of psychological depression, fatigue, decreased concentration, memory loss and mood swings may come on slowly and insidiously.

Notify your physician promptly of any adverse reactions, especially breathing difficulties, fluid retention in the legs or a night cough.

Corgard can interact with a number of other compounds, including several that are used to treat asthma, colds, allergies, diabetes, migraines and heart problems.

Corgard and the blood pressure medicine Catapres may not mix well, but neither one should be stopped suddenly.

An allergic reaction to penicillin or ampicilin may be more severe in an individual taking Corgard.

Arthritis medicine and aspirin may reduce its effectiveness.

A barbiturate such as Fiorinal or a tuberculosis medicine like Rifadin could also interfere with Corgard's effectiveness.

Check with your doctor and pharmacist to make sure Corgard is safe in combination with any other drugs you may take.

Special Precautions

Some people should rarely, if ever, take beta blockers like Corgard. Asthmatics and patients with other respiratory problems are especially vulnerable, as these drugs can make breathing worse.

People with heart failure must also be extremely cautious if prescribed beta lockers as the medicine could lead to cardiac complications.

Never stop taking any beta blocker medcation abruptly unless you are under very close medical supervision. Angina or a heart attack could occur.

These drugs may also make treatment of diabetes and thyroid disorders more complicated. Your doctor can tell you what additional tests and precautions you will need in managing these conditions.

Taking the Medicine

Corgard can be taken at meal time or on an empty stomach. If you find this medicine causes digestive tract upset it may be better tolerated when taken with food.

Because of its long duration of action in the body, Corgard offers the convenience of once daily dosing.

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6 Comments

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I have been on Corgard 20 mg for 7 years now. Started as a result of first-time taccycardia. In the past few years I've developed very bad back/muscle pain in upper and lower back along with some mild GI problems. I've been xrayed, mri'd and cat scanned and they can't find any physical reason for the muscle aches/spasms/pain. I have been wondering for quite a long time if it is related to the Corgard as I was never on any medication prior to the taccycardia event.

Should I ask my doc to taper me off this med? I've luckily only had 2 episodes of taccycardia in the past 7 years and they've resolved on their own by the time I got to the ER. My doctor dismisses the idea that the Corgard could be causing all my muscle aches and pains, especially in the back, but there's nothing else I can think of. Sometimes even my legs ache or hamstrings get tight. I've been told I either have some arthritis or that I'm developing fibromyalgia.

It just seems odd that I've gone from perfectly healthy physically and actively to having these pains after being on this med so long. Again, my doctor just brushes my suggestions aside. I've already had one cardiologist tell me I could try stopping it as I'm only 47 and she doesn't want to see me stay on it if I truly don't need to and thinks being put on it immediately after just one episode of taccycardia without any further heart testing was a rather quick decision vs. having some tests first and then deciding. When I mentioned this to my primary care he said he'd rather I continue to take the med. Also I've always had normal BP. I'm just afraid of all the warnings not to just stop it because it could cause a heart attack. That terrifies me.

Why is my cardiolgist saying try to wean off of it and see how you do, and my primary saying nonsense, it's a low dose keep taking it? Meanwhile I've developed all these weird aches and muscle spasms, I feel tired, and I have noticed my concentration isn't what it used to be. Could be the difference between being then 40 and now 47, but I don't think so!

I am a 50-year old woman, healthy, active and weight-appropriate for height. I have been on Nadolol (40 mg/day)for 15 years, initially prescribed to treat arrhythmia and migraines. After several years of increasingly severe beta-blocker side effects, the doctor finally listened to me and switched me to propranolol (which did not work for me,) then to metoprolol (which is working ok but not great.)

In the 2 months since getting off nadolol, I have been dealing with not only the side effects common to beta-blocker use, but also constant tremors. The tremors get worse as my activity level increases, my immediate environment gets more distracting and/or I try to use my hands. The doctors are at a loss, and are sending me to a neurologist for tests.

This appears to be tardive dyskinesia due to long-term use of a dopamine-receptor blocker (which is what a beta-blocker is!) If anyone else has any comments or similar experience, PLEASE respond!

I too have just gone off Corgard and I too am experiencing shakes . . . I'm hoping this will go away after a while as I've only been off Corgard for a couple of weeks. How are you doing now?

I went off the Metoprolol after two months, and the tremors became severe and constant. It has been six months now, and I am learning to live with this disability. The doctors are calling it "essential tremor", and suspect the long-term use of beta-blockers either caused or contributed to the tremor. It is permanent, there is no cure, and the only way to reduce the tremor is to go back on the beta blocker or take other drugs that mask the tremor.

I am currently off medications altogether, and coping with the heart condition the beta-blocker was originally prescribed to treat. I have found some relief (tremor & arrhythmia) by taking specific vitamins, minerals and enzymes as prescribed by my neurologist. This does seem to reduce the severity of the tremor and arrhythmia, but will not make either go away. I will look up the list and dosages, and email them tomorrow.

A word of caution - be very careful about taking any other medications. They all have side effects, and you already know what the beta-blockers have done to you...

Rose- I had muscle pain while taking beta-blockers also. Once I got off them, the pain went away. I still have arthritis, but I am no longer in constant pain anymore. Muscle and joint/bone pain are some of the side effects they don't tell you about...

I also felt like I had problems concentrating, couldn't remember things, etc. I was tired all the time, just exhausted. This, too, resolved after stopping the med.

I have been on nadolol for maybe 9 months or so for migraines. 6 months ago, at the same time as I had a flu jab (maybe a coincidence), I started to get this cold feeling across the upper part of my back and this awful aching like I have flu. I've seen the doctors lots of time about it and next week I'm going for a couple of distasteful procedures at the hospital which might turn up some reasons (there are other symptoms which led them to go down this route).

I'm beginning to think though that just maybe the cold feeling and aching might be down to the nadolol. Does anybody think I might be on the right track?

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