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Metformin

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Overview

Glucophage is a relatively recent diabetes medicine in the U.S., although it has been available in other countries for over a decade.

It is prescribed to people with NIDDM, or "adult onset" diabetes.

Although it lowers blood sugar both right after meals and between meals, it works differently from most other diabetes pills.

It improves the body's response to insulin and reduces the liver's output of sugar.

It also lowers blood fats somewhat, and it is hoped this will reduce the risk of heart disease.

Glucophage may be used alone or in combination with other diabetes pills.

Side Effects and Interactions

The most common side effects of Glucophage are digestive: loss of appetite, nausea or diarrhea. These may fade with time.

Rash, flatulence, and a metallic taste have also been reported.

One rare but serious adverse effect may occur when a person has kidney problems or becomes dehydrated.

Lactic acid may build up in the bloodstream and lead to dangerous consequences. Contact your doctor promptly if you feel ill, with muscle aches, trouble breathing, stomach pain and drowsiness. Blood tests will determine if lactic acidosis has developed. This is a medical emergency.

If Glucophage seems to be losing its effectiveness for controlling blood sugar, discuss the situation with your doctor.

Furosemide (Lasix) can increase blood levels of Glucophage, while levels of furosemide may be lower than expected.

Nifedipine (Adalat, Procardia) can also boost Glucophage levels modestly, while cimetidine (Tagamet) can raise Glucophage levels substantially.

Other drugs, including Lanoxin (digoxin), quinidine and Zantac (ranitidine), might theoretically increase Glucophage blood levels but no interactions have been reported yet.

Medications such as cortisone or estrogen that tend to raise blood sugar may interfere with the effectiveness of Glucophage.

Check with your physician and pharmacist regarding potential interactions of Glucophage with any other drugs or herbs you take.

Special Precautions

People with poor kidney function may need lower doses of Glucophage to avoid a dangerous build-up of the drug.

Older people may also need dosage adjustments so that they take the minimum possible dose that controls blood sugar.

Periodic monitoring of kidney function is essential.

Glucophage should be stopped temporarily before surgery or any x-ray procedure using iodinated contrast media ("dye"). Ask your doctor for specific instructions.

Taking the Medicine

Glucophage is usually taken with meals, twice a day.

It works best in patients following a sensible diet for diabetes.

Excessive alcohol intake can increase the potential for a serious reaction and should be avoided by people taking Glucophage.

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117 Comments

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Side effects from Metformin can be delayed quite some time after starting the medication. I began taking it about 5 years ago, with good results, for a considerable time. Then I began to have digestive problems with stomach pain and diahrrea after eating certain foods. First to go was hot peppers which I had eaten all my life. I developed GERD and later began having episodes of stomach cramping and diahrrea with no obvious food connection.

My doctor was doing a guessing game... stress?, irritable bowel?, gall bladder?, lactose intolerance? The cramping, diahrrea became more frequent until it occured about 2 times a week. A year ago I had a 3 week episode of diahrrea and my doctor finally said to stop Metformin.

Within a few days I was much better and have been re-introducing foods I previously avoided. I can now eat hot peppers and other foods I stopped. Metformin was the cause.

My doctor prescribed two medications Metformin and Simvastatins. I took the dose as prescribed, and felt as if I had been food poisoned. I had diarrhea, stomach pain and my stomach was constantly grumbling for almost the entire day. Every time I tried to eat, my stomach got upset.

I had other serious side effects like dizziness, fast, racing heartbeat, felt like I had low blood sugar, and I had even tried to take half a dose, but it does not work for me. Not to mention my stomach has not been the same ever since I took the medication.

Do you think that Sea Buckthorn oil could be a better choice?

I've been on Metformin for 10 years. Recently with Teva. A1Cs around 6 and fasting glucose on average 100. I switched pharmacies and now get Metform made by Watson labs. My blood sugars are all over the place. Fasting 161! I feel like I'm "getting" diabetes all over again. I will try to switch back. Is this normal?!?!

I've recently received a "new" generic of Glucophage from Sears Pharmacy (k-mart) and my blood sugars are also sky high (to what they normally are). I've got the pharmacy looking into the new manufacturer, but I'm scared to death. I always had an afternoon blood sugar number of around 110 and now it's near 190!! Anyone else having the same problems? I've even cut out more and more carbs, but it seems like it continues to worsen.

My son had been on Metformin for over 3 years.(500mg 2 x a day) He did well on this until mid January. When we picked up a new prescription. It was manufactured by tiva and looked slightly different than it usually does. He had many side effects; began gaining weight, heart palpitations, stomach problems, acid reflux..the list goes on..After speaking with his Dr we changed him to brand name glucophage and he is doing much better.

I was on Metformin 500mg (3x/day) for PCOS (poly-cystic ovarian syndrome) and not for diabetes. Metforman can help reduce the raised androgen (testosterone in women) that contributes to PCOS, thereby regulating hormone levels. I had taken regular Metformin for 2 1/2 years with no problems and then when I received a different generic version of Metformin from my mail-order pharmacy, it smelled awful! Like dead fish!

I tried it anyway, but felt progressively worse over a month's time, more fatigued and achy. So, having a left over prescription of Metformin from a retail pharmacy, I switched back to that and have felt great since. But, I'm considering going with the brand Glucophage instead of doing the generic Metformin.

I have been diabetic for a little over 4 years now and taking Metformin. After my mail in pharmacy changed their brand of generic metformin I noticed that my blood sugars are much higher. I do check them 4 times daily and still at the same times. I changed back to a local pharmacy and that very evening they were back to the lower levels that they had been on.

Once again the local pharmacy has changed to Teva and have been trying them again and having the same elevated levels and they also do smell very bad.... as someone said like "dead fish" but I actually think "like dead and rotten fish." I have asked my pharmacy to order the other generic brand for me and they said they will check to see if they can do that.

If not I will be changing pharmacies! I may also send some of these Teva pills to have them analyzed to see what is or what is not in them???

No, my doctor put me on Fortamet which is non generic and I'm back to normal. Sometimes I think bad batches get in the system.

Can Metformin cause depression?

PEOPLE'S PHARMACY RESPONSE: THIS REACTION HAS NOT BEEN REPORTED.

Did not see it as a side effect....but depression has been related to diabetes most recently.

Please, can anyone tell me what the "bad" generic metformin looks like. My husband has just started taking this medication and so has no baseline of effects to refer to. We would like to avoid negative experiences from the start and so are thinking about getting the name brand version.

I was on Metformin and then Metformin ER for about 11 years and just spent the past 10 months with increasing GERD and acid reflux and esophageal spasms. Tried everything... kept getting worse. Stopped Metformin ER and felt better same day.... no kidding.... better by the minute.

Been on glyburides and metformin for over 13 years. Have all the symptoms accompanying type-2 diabetes and aging (metabolic syndrome) --- fatigue, acid reflux (possibly due to hernia also), wt. gain and so on.
One of the known side effects of metformin is mal-absorption of B12; I have had to take intramuscular booster shots every month (1000mcg). Sub-lingual tablets had little effect. B-12 analysis should be part of bloodwork -- since it regulates numerous other functions.

My questions:
1.what do you substitute when you stop glucophage xr?
2. what is a good replacement for omeprazole for acidity and acid reflux (long-term; I do not plan on surgical remedy for my hernia).

Been taking Metformin for 3-4 years now for PCOS and not diabetes. In the past 2 years I have developed food intolerances and allergies. Symptoms started out as vomiting, diarrhea, stomach pains, grumbling of the stomach. Had my allergies checked and found that I was allergic to foods that I had grown up eating. I'm a vegetarian and being allergic to fruits and vegetables is very difficult. I want to know if there is a way to find out if metformin could have caused the development of food allergies and intolerances.

PEOPLE'S PHARMACY RESPONSE: WE ARE NOT AWARE OF METFORMIN TRIGGERING LATENT FOOD ALLERGIES.

Glucophage was prescribed to me and I instantly got severely sick in my stomach. I instantly developed severe reflux, to the point of being in the hospital several times. The doctors want to put me back on it for PCOS but I know that it contributed to the development of GERD which I am now taking Nexium for. I also have awoken many nights with an inflamed esophagus and feel like I can't breathe from the GERD.

Can Metformin cause depression?

I have been taking met. for just over a month now and recently I have thought that I was suffering from depression. I am lucky to have got early retirement but I do not want to do anything!!! I am quite happy to just sit and watch videos or DVDs all day long.

Today I had to get a repeat prescription so I asked the pharmacist who told me that my body is adapting to the met and that I am suffering from lethargy! That was probably the kick up the backside that I needed as I have been out walking most of this afternoon.

And now I have a nice warm glow on my face from the sunshine. Hopefully this is going to resolve my problems.

I have been on metformin for 10 years for PCOS. It has been wonderful until recently. When I started out I was on 500 mg per day, then 1000 mg, and finally 1500 mg. It helped regulate my cycle, helped with acne, helped me loose weight, and I felt great. I was able to conceive on the first try and with only one miscarriage, had a beautiful, healthy baby.

I did have some minor intestinal issues, but nothing major. The last few times I've had my Rx refilled, the pills from TEVA smell horrid....DEAD FISH--enough to make a person gag. I started getting very ill, nausea, severe diarrhea, itchy rashes, flu like symptoms, and very smelly body odor. It felt like the dead fish smell was oozing out of me!

I took the pills to my doctor after I figured out that it must be these horrid smelling pills causing the problems and she said to stop taking them immediately. I've been taking this drug for 10 years without problems until the last few months. I've had other generic versions without problems. She told me the actual medicine has to be the same, but they can use different fillers with the generic versions.

She wants me to stay off metformin for a couple weeks to let my body settle down and then she's going to prescribe glucophage. It's been almost a week and I feel like a new person! I believe there is something harmful in the TEVA fillers. They are produced outside of the US also, which gives me less confidence in their purity.

I will never take the TEVA metformin again and I'm wondering about their other generic drugs also. I do not have any faith in their products. I would like a lab to test the pills to see what's really in them?

I just started taking metformin HCL ER 500 mg tab (Sun Pharmaceuticals) and started at 1 pill a day with food then last week at 2 pills a day with food because the diarrhea symptoms stopped. Now I have constant burning in my throat and chest, which does not go away with nexium (which I was on before I started it) or Gaviscon or Rolaids. It feels like I swallowed a whole box of pepper.

I have severe Acid Reflux to the point of leukoplakia on my vocal cords which was going away until this constant burning started (which is nothing like the GERD symptoms I had). I do not see this burning as a side effect anywhere. Am I reading your posts correctly in that there are different types of this drug? Which one works the best? Should I ask to be put on Glucophage or is there really a difference? Thanks for your help.

I have been on metformin and glyburide for probably six years. The last few months, I have given up coffee and drink green tea throughout the day, five bags brewed in a pot of water in the morning. I have lost ten pounds over the past few months with about forty to go to achieve the ideal weight.

I recently developed diarrhea, nausea, weakness. I am considering the potential causes and wonder whether it could be the metformin?

PEOPLE'S PHARMACY RESPONSE: DIGESTIVE DISTRESS IS COMMON WHEN STARTING METFORMIN, BUT IF IT OCCURS AFTER MANY YEARS AS IN YOUR CASE IT COULD SIGNAL A SERIOUS COMPLICATION, LACTIC ACIDOSIS. PLEASE CHECK IN WITH YOUR DOCTOR PROMPTLY.

My mother has been taking metformin for years, and just last year we noticed a change in the way she behaves. She is in her early fifties, and has a really hard time speaking, putting sentences together, finding her words, and driving among others -- on a daily basis. She was perfectly healthy before this, and we thought that maybe she had a silent stroke due to the doctors not being able to find any reasons why she had this behavior. Recently, I have heard that metformin can cause this in an individual, and I was wondering if anyone has any more information on this? Your help is much appreciated!

PEOPLE'S PHARMACY RESPONSE: YOUR MOTHER'S DOCTOR SHOULD CHECK HER LEVEL OF VITAMIN B12. METFORMIN CAN LEAD TO GRADUAL DEPLETION OF THIS VITAMIN, WHICH IS ESSENTIAL FOR NORMAL BRAIN AND NERVOUS SYSTEM FUNCTION.

Sorry, I forgot to include this information, but my mother has been receiving a B12 shot every month due to this fact, but it's still not working in making her any better, in fact she seems to almost be getting worse. Is there anything else that could possibly help this?

Does metformin cause hair to fallout in hand fulls?

I started using Metformin and had diarrhea so severe that I could not leave the house. I used to not drink or eat on any road trips. There was running to the bathroom sometimes even during a meal. I was so ashamed of myself having accidents. One time on the way to my car with my grandkids. But they did not know, I covered up the smell and sat on a sweat shirt in the car. Then after a 11/2 years of this a new shape metformin had stopped almost all of these episodes.

Then, one day I decided to use up the few old ones and bang, the old symptoms back. Hurry, get to the bathroom and oops I've had a accident getting their. Now, after reading all the info out their, I plan on getting info from my pharmacy. What Hell this has been. Test, after test. Then I came across the Habba syndrome on t.v. and thought this is me.

With my gallbladder out, now at least I can bring up the name of the medication Welchol to help this dangerous disease from keeping me down. Thanks everyone for your info, it is greatly appreciated.

Just started with Metformin and I used to be lactose intolerance and now I can have milk with no problem. Is that unusual? No problems. Feel great. Thanks

Hi! I have to comment on your post... I have become extremely ill with the same symptoms... terrible burning in my throat and chest, extreme, nothing like any typical acid reflux that I have had in the past... I always take in my med list to the many doctors I have consulted, but until a visit with my endocrinologist, no one said that metformin could be the problem.

I told her I was having extreme distress, just constant pain and burning and she told me I may want to try to stop taking the metformin (I was taking it for insulin resistance). I pray that stopping this helps. I just looked for more info and found this site. I also checked the bottle of metformin and noticed that mine was also manufactured by TEVA USA.

I have been so ill, not just the burning but vomiting and stomach pain also. I have been on metformin for probably about two years, but stopped taking it yesterday. anyway, I hope you find relief, and I pray that this helps me because the burning is about the worst thing, and I have been through some really bad health stuff.

After reading other commentaries on this topic, I have to say that I am shocked to find people that have been on meds for close to a DECADE are experiencing serious metabolic symptoms - yet still believe the prescription will save them. Does anyone suspect that Rx manufacturers may have a problem with control? Does anyone suspect that the Docs prescribing these meds really DON'T KNOW much about them - other than what the manufacturer has claimed? Does anyone suspect that BIG PHARMACEUTICALS don't really care about your health, and that BIG PROFIT is the name of the game? No? Do your research.

I was just Dx with Type II 1.5 years ago. I was diagnosed with lactose intolerance a couple of months ago. I began a Statins one year ago, and Metformin 8 months ago. I was never lactose intolerant until 8 months ago - the same month I began Metformin. I have been a lacto-ovo vegetarian my entire life - I am a 50 yo female. Hmmm.

After eliminating dairy in my diet, I have lost 35 lbs in 3 months and feel better than I have in months. My blood sugars started registering in the 90s - I believe because of the elimination of lactose. Regardless of whether or not Metformin pushed me over the edge to lactose intolerance, I am experiencing better health because of it. I took myself off the statins and the metformin and am beginning to feel like myself again. I don't eat all the foods that I used to eat, but I eat all the foods that are needed by my body.


Please please please begin or continue to be your own advocate. Do your research. Ask questions. Listen to your body. Find a doc who is not a pharmaceutical parrot. Develop a relationship with a Nutritionist. Most metabolic disorders can be treated or managed through food - your fuel - and without dangerous medications.

I have been taking metformin hcl for type 2 diabetes prescribed by the family doctor for several months. I was seen by the doctor for glucose check and it was at 246 still high. Then my doctor told me to increase the dose to 2 tabs a day 500mg each. I never felt so sick all over my body like flu symptoms, nausea, frontal headaches, upset stomach.

This medicine is horrible period. I have been feeling these symptoms everyday since increasing the dosage. It sounds like metformin is a great drug to treat for type 2 diabetes but I totally disagree. I will inform my doctor that I do not wish to continue to take this awful drug.

PEOPLE'S PHARMACY RESPONSE: METFORMIN CAN BE HARD TO ADJUST TO, BUT ONCE YOU HAVE IT IS HELPFUL. IF YOU START TO GET STOMACH SYMPTOMS AFTER YOU HAVE ADJUSTED, THOUGH, SEE YOUR DOCTOR RIGHT AWAY AS IT COULD SIGNAL A SERIOUS REACTION.

Hi! I took metformin for a year due to PCOS. But due to side effects like vomiting, I stopped for like 6 months. Now I'm back to metformin again. It's my 4th day now and I'm still experiencing this side effects. Last night I vomited 3 times and was craving for foods. I also felt terrible depression and cried for hours while my husband tried to cheer me up. Is that normal? I'm not pregnant. I'm taking 1000 mg a day, should I decrease the dosage? thanks!

PEOPLE'S PHARMACY RESPONSE: PLEASE CHECK WITH YOUR PHYSICIAN ABOUT DOSING AND SIDE EFFECTS!

GERD (acid reflux) can be cured by drinking apple and potato juice on an empty stomach every morning. Please try.

I too had these same symptoms. They tested me for heart and stroke problems. As a last resort they sent me to a neurologist who put me on Lamictal because he believed I was having mini-seizures in my sleep. Within two hours of the first dose, my head cleared and I was back to myself. That was over two years ago and the symptoms have not reappeared.

I was SHOCKED to hear of people reporting "bad" products from Teva! A couple of years ago, my pharmacy started carrying Clonazepam (by Teva Pharmaceuticals). I took the stuff, as directed, and then began experiencing severe benzo withdrawals (Clonazepam is a benzodiazepine). I wound up hospitalized. To make a long story short, I got "bogus" Clonazepam!

I switched pharmacies, and all was well (for a year). Then my new pharmacy switched to the "bogus" stuff, by Teva. Wound up in the hospital again. Found out that almost every pharmacy in town was carrying the crap by Teva! Switched to a NEW drug altogether. The hospital confiscated the "bogus" Clonazepam and sent it to the FDA (a year ago).

I'm shocked to hear that nothing has changed. My doctors, and a bunch of pharmacists thought I was NUTS (because I made the claim that this drug wasn't the real thing!) Makes me wonder how many more of their products are fake?

Well I'm about to join the crowd here!... just started glucophage 3 months ago...now my life is almost 100% terrible stomach pains, throwing up or feeling like I'm going to (or would LOVE to) sometimes for 5 or 6 hours ever morning... tried to figure out if all of a sudden I'm lactose intolerant sure enough I cut out all lactose for 3 days and feel better (but not perfect) and YES losing weight (I'm not hungry and even smells of food make me a bit gaggy)...BUT here's the problem also..I'm TIRED ALL the time... worn out completely and yet I'm not doing any more (and now for sure LESS) and I feel like I'm exhausted from doing hard labor!!!

I don't care WHAT anyone says... it's FAR TOO MUCH of a coincidence for both to have happened at the same time!

I was put on Metformin SunPharm 500mg x2 daily took it for a month a bit of stomach probs but no real side effects. Doctor decided to increase dosage to 850mg x2 daily and I just took them twice they were made by TEVA got abdominal cramps and diarrhea.

Can it be the TEVA brand? I will try to switch to different generic brand. Yes the TEVA ones smell like dead fish.

PEOPLE'S PHARMACY RESPONSE: IT MIGHT BE THE BRAND, OR IT COULD BE THE INCREASE IN DOSE. DIGESTIVE PROBLEMS ARE COMMON AT THE OUTSET OF METFORMIN USE, BUT GENERALLY DECREASE WITH TIME.

I switched to Target for my Metformin and then the trouble began. My regular deodorant failed me. Deodorant hadn't changed. Switched a few times, but still had problems. My mouth tasted funny and I would wake up having to brush and use mouthwash at 2-3AM. My urine was darker all day even though I drink 10-12 glasss of water daily. My urine had a rotten fish type smell. Loose stools and cramping every morning. I was getting scared wondering if I was getting really sick. Teva was culpit! Changed to old pills (not by Teva) and all my strange symptoms went away within 5 days. Why do pharmacies deal with this problem producing company?

PEOPLE'S PHARMACY RESPONSE:

Of course we have no way of knowing whether the Teva product is to blame. It could be pure coincidence. Nevertheless, we do appreciate you reporting this problem. Please report it to the FDA via their MedWatch program at:

https://www.accessdata.fda.gov/scripts/medwatch/medwatch-online.htm

Hello everyone. Let me first begin by saying that you are all in my prayers for health and healing. I have a diagnosis of both PCOS and Depression. I have been taking Zoloft for about 3 years, Prometrium (which I like because it is a more natural form of progesterone that brings on my period) for the past year and Metformin now for only one month.

I am having some serious issues with the Metformin that maybe you ladies could help me out with. Of course, I still discuss everything with my doctor. There are two major concerns I am having about the Metformin since I started a month ago. The first one pertains to immunity. I feel as though my immune system has been very weak since I started Metformin and now I am having a lot of candida/yeast problems and have already done creams and 3 diflucan in this first month.

Is something wrong here? Has anyone else experienced this with Metformin before? Now I must say that I have had a vulnerability to infection in my medical history, but I am being totally honest when I say this has been 100 times worse with the metformin. The last thing I wish to ask for anyone with the dual diagnosis of mental health issues like depression and bi-polar, along with PCOS. If this is you and in addition to PCOS treatments you take a medication like Zoloft, have you been having serious brain fog and irritability since you started Metformin? Any advice or comments that you might have would be greatly appreciated. Thanks.

Megan

My doctor, who is new to me, took me off metformin. I went to him because he perscribes armour, natural thyroid medicine. He said my hormone levels where good, blood pressure 120/80, cholesterol 210, which he said was high.. I am worried though he is having me take half my dose of blood pressure medicine and took me off my metformin said my insulin was 120.

I just wondering if everything was good because of the medicine. I go back in a month how will I feel if my body really needs metformin to function correctly?

PEOPLE'S PHARMACY RESPONSE: IN A MONTH YOU WILL HAVE A BETTER IDEA OF HOW YOU ARE FEELING. IT WILL TAKE A FEW WEEKS TO FIGURE IT OUT.

Only your doctor can tell you how much Metformin and how many times a day you need to take. Do not take more or less of it than what your doctor has prescribed. Metformin controls diabetes but does not cure it. Continue to take metformin even if you feel well. Do not stop taking metformin without talking to your doctor.

Not everyone who takes metformin is a Type 2 diabetic. Metformin may be prescribed for other uses; ask your doctor for more information regarding this.

It depressed me. I cried all the time yelled at everyone and wanted to die. And that was on top of the cramps, the awful cramps. I couldn't leave my bathroom. And they even tried slow release it was worse. I am on it for pcos.

I have been on metformin 2 times, the reg one and the slow release and both times about 4 days in I get horribly depressed and I cry uncontrollably. I think of death, I don't want to get out of bed, on top of all I that I am SUPER MOODY!!! I say really bad things to people who I love I am hateful, and my tummy hurts so bad that I cant move. Also I have to LIVE in my bathroom taking Imodium with a pepto chaser!

Is it ok for me to continue taking Metformin since I had my gall bladder removed?

PEOPLE'S PHARMACY RESPONSE: THIS IS A QUESTION FOR YOUR DOCTOR, WHO WILL PROBABLY SAY THE GALL BLADDER DOESN'T AFFECT YOUR NEED FOR METFORMIN.

Seems that since I was switched from actos to metformin my depression has suddenly become worse. Also gastrointestinal problems have become worse. I'm not waiting will stop tonight and go back to actos and see how I feel. Also issues I have with pain have become like an all over my body now and its my suspicion that it is the metformin. I've learned to be my own advocate since most doctors don't hear what you are saying and don't think any big pharma product could be bad.

90 year old mother prescribed metformin - not in excellent health - glucose reading 117 - so many side effects unsure if safe for her - your opinion? thanks

I have taken 500gm Metformin 3 times a day for the past couple of years with no problem at all. 4 weeks ago my Doc upped my dose to 850gm 3 times a day, and I've had a problem ever since (severe pain, indigestion, tiredness, watery stools). The new metformin was from Teva, so I'm assuming I have a problem with this make. I'm going to switch back to the 500gm until I can a prescription filled with another make.

I'd see my Doc, but its quicker to get a new prescription filled!

My husband has been taking metformin for about five years. He's has a loss of appetite, and problems with sleeping. A couple of weeks ago I refilled his prescription and I think he got a bad batch. He's experiencing intestinal cramping, loose stools, and for the past ten days or so his glucose readings have been going higher and higher, though he hasn't changed his eating or drinking habits.

Usually, on the weekends his glucose readings go down into the low 100's, but now they seem to be rising every day (he takes it first thing in the morning). After reading this discussion board I'm going to call our pharmacy - we use Costco and ask if they recently changed vendors. Several years ago I had a bad reaction from a generic drug that landed me in emergency! So I can see where there can be bad batches out there. This is a great website. So glad I found it. And of course, we will talk to our doctor about these problems.

Lately for the past year of so, he can't stand eating eggs over easy or poached - he says the texture etc. turns him off - he use to always eat his eggs that way for years and year. Has anyone had the same experience?

I've just switched from TEVA metformin back to my usual brand, and the horrible cramps and diarrhea have gone. Not sure if this was a bad batch, but I won't be taking this brand again!

I started Metformin last year and after a week I started to feel depressed. My doctor said he never heard of that side effect. I know what depression feels like. Been there, done that and once I started feeling it after giving it two weeks on these meds I immediately quit. And just to make sure it was the drug and not a true bought of depression I gave it another test 6 months later (not on any supplements or other medications either time) and sure enough after 5-7 days I felt blue. No met for me. :)

I just started metformin 1500mg daily last week. I know exactly what you are speaking of. I do not believe it's depression, more like a mopey I do not want to get out of bed type of attitude.

I had been on metformin three years ago and I went through the exact same thing for about 3-4 weeks. It went away for me and I am already starting to feel a little better this time around. Best of luck to you!

I have been on metformin for a year and a half. I was fine up until about a month ago then I started having trouble with the worst burning sensation in my stomach and throat. Yesterday it made me so sick that I could barely function so I quit the metformin it has been a little over 24 hrs since I took it and I feel better already. I still have a little bit of the acid feeling in my throat and stomach but nothing like the other day so I am crossing my fingers hoping that I will not have anymore problems.

Hi there, I suffer from biPolar disorder and have been effectively medicated for about 7 years now. I started Metformin about 4 weeks ago and at the drop of a hat I get irritable and cranky. I also lack motivation and yes, have a brain fog too. I have decided to drop back down in dosage to see if this combats it, though I have also been informed that it is temporary until my body regulates... so who knows what to believe really.

I feel horrible. Stomach Gas Pains, Cramps, Diarrhea without warning, Constipation, heartburn.... I have no appetite, and the only thing that makes me feel better is chicken broth and crackers, and cereal. I take 500 mg twice a day...BLAH is all I can say.

My husband has been on Metformin for about a month and a half and I'm not liking what I see. He is very depressed has "given up" and doesn't seem to be living except to go to work everyday. I'm scared and not liking this one bit. I think I will be calling his doctor to find out what to do about this. He also experienced the stomach problems. And I don't think it is really helping his sugar counts that much. They are still in the 200's. They did seem better at first, but not anymore.

My son is 23 and taking metformin as part of a weight loss program. For the last 3 days he has had stomach pain and dark green to almost black green diarrhea. I haven't given him any medication since Sunday night. Have a doctor's appointment next week and have spoken to a pharmacist. Pharmacist doesn't seem to think there's anything to worry about. Need to know if anyone else has experienced not just diarrhea but dark as well every time there is a bowl movement.

Feb. 14, 2012
First off, thank you for your comments. It's inspired me to write this to help others as I found help on this site.

I was diagnosed with pre-diabetes for years. Recently, my sugar levels rose dramatically and I was put on Metformin. My doctor said try the free pills at publix. I did. The heartburn was severe. I looked on the net, and it appeared the long acting had less issues with this. However, my blood sugar levels were all over the place.

I saw an endocrinologist who gave me a month's supply of Glumetza 1000ER. When I got home, I looked the drug up and was perplexed as it's still metformin. So I asked the Publix pharmacist, who explained the following:

  • Generics must be 10% within the original formula. That means 10% more or less of whatever else is in it.
  • The 10% difference can be fillers, or something totally different.
  • He said some people do fine on the generics; others do not - they are NOT the exact same formula.
  • Within 9 days on the Glumetza, my blood sugars stabilized. In addition, it was suggested I call the local hospital and get in a new diabetics class - which I got a prescription for. I had already seen a dietician, but the diet she put me on actually was too high in carbs, according to the endocrinologist.

    A lot of "new" things are out there for information. Unfortunately, it takes time, and patience, which most of us are low on when our sugar levels soar and drop w/ no rhyme or reason. I will take the classes.

    If you do not stabilize w/i two weeks of any drug or see some continued improvement I would go back to your doctor and get a NON Generic formula to try. What a huge difference!

    I have pcos and I've been but on 850mg of metformin to help see if it helps me to have a bleed. I've notice every time I drink milk neat or have it in tea or coffee I feel sick, and my lips go numb and tingly. I've stated drinking lactofree I don't have them symptoms. Now I'm scared to have anything with milk in in case I feel ill again.

    I have been on metformin for 4 years. I have taken it with no problem until about 10 days ago when I started having terrible dizzy spells and a funny woozy feeling in my head. After reading these comments, I looked at my prescription bottles and see my drug is made by watson labs. I started a new bottle close to when these symptoms started. I am going to try a different bottle and see what happens.

    I've been taking metformin for about 10 years now. Not for diabetes but for PCOS. For many years metformin seemed like a miracle and in many ways still does. I had about as many symptoms of PCOS as you can have including no menstrual periods, facial hair growth, crops of skin tags, aggravated carpal tunnel and acanthosis nigracans (a skin condition related to insulin resistance) which all resolved within 6 months after starting the metformin.I did have some gastrointestinal side effects for the first few weeks that involved spells of intense nausea but these went away after a few weeks on the medicine.

    The last year or so however I have been having increasing levels of gastrointestinal issues that my doctor has classified as irritable bowel syndrome and have been having trouble with food intolerances. My diet and activity has not changed so I didn't know why I was having these issues. I've recently added more lactase supplement for my known lactose intolerance as well as an acidophilus supplement and this seems to be helping tremendously with the gastrointestinal problems. I've also read that long term use of metformin causes vitamin B12 deficiency so I'm going to start supplementing that and see if it also helps.

    I had acid reflux like yours... used to wake up feeling it surge up into my throat... remember running or more like staggering around the house trying to get breath.

    I took drugs for it and they helped. Then I lost my health insurance. On a forum about that I learned about Aloe Vera Juice for acid reflux. Walmart and about $8 a gallon. Hand trimmed is mild and easy to drink... machine trimmed is horrid.
    Trader Joes, the other inexpensive source, switched to machine trimmed.
    Walmart has the good stuff.

    Anyway my gosh it worked. I drank it before bed, about 6 ounces and it all went away after awhile. I was in an area where it was not available for a price I could afford and I stopped for the time I was there... about 7 months... it did not return so I am an occasional user now.

    A recent test showed that the hernia is just tiny now, after being big enough that it needed surgery.

    I had to stop taking it due to physical depression, crying and wanting to blow my head off, I am normally a happy up person, but I seem to have all of the side effects: vomiting, watery, black diarrhea, head ache, cramping, insomnia and well, all of them, I just looked up to see if depression was a symptom, I guess it is, I am stopping this stupid medication and will call my dr first thing on Monday... it is great that it works for most, but it sure is no fun when a person gets side effects so severe they can't leave the house.

    I have taken Metformin in varying doses for 7 years. The only side effect I have had is diarrhea - about once a week. I have struggled to figure out what triggers it off, and have self diagnosed myself with irritable bowel and lactose intolerance. I strongly doubt it is either of these, but rather specific food at specific times. I now believe it is either coffee or milk (my favorite Trim/skinny Flat White!) taken in the morning that seems to trigger the diarrhea.

    Does anyone else have similar experiences?

    I started Metformin a couple of years ago and immediately experienced serious symptoms of depression, including thoughts of death and sudden anger - however these disappeared after a couple of weeks. I still get occasional stomach upsets and milk seems to make it worse. However, my blood sugar levels are user control and I think the side effects are worth it long term.

    The depression was scary, especially since I am by nature a calm, very positive and optimistic person and had never experienced anything of the sort. However, once you pin it down to the side effect of a medication, it is easier to rationalize your feelings.

    Best of luck!

    I've only been on Metformin ER 500 one time a day for a month and had depression symptoms for the first two weeks, then they went away but are back again. I don't want to get out of bed in the morning or go to my exercise classes than I love. I'm in a bad mood and sad, which is NOT my normal personality. I read nothing about depression as a side effect in all my readings, but this medication HAS to be the cause of how I feel.

    I started on Metformin 500 MG Extended Release last week and have felt terrible since starting this. They found it is interacting with the Topamax I take and changed this to the standard Metformin 500 MG, however, I too have noticed since starting this medication that I am exhausted, have muscle/joint pain and feel very sad, depressed and negative... NONE of which I felt prior to taking this. I am a high energy, positive person in my usual state.

    I am stopping this immediately since I am not diabetic and only started this to reduce belly fat caused by surgical menopause. I know that I am sensitive to medications and also bipolar and all of this contributes to this but wanted to share this information as well. I would prefer a natural alternative and plan to see my accupuncturist today for some cleansing from this toxin. If you do not need medication it's best to not take anything so much of what we can heal ourselves with is through diet, exercise and overall balance.

    Thank you for sharing your information here it has been so helpful to read. Peace, health and blessings to each one of you! Wellness is the greatest gift, without it you can do nothing.

    I was switched to 750 metformin er. I first, I experienced smelly urine, then nausea and dehydration. After seeing these comments, I checked the mfr: Interpharm. These are generic from Target. any sugestiosns? When I tied metformin before, I was ok on 500 but became dehydrated at 1000. My doctor moved me to Janiuvia... which I have come off of because of health concerns. My baseline diagmnosyic reading was 127....just one point over the diabetic threshold. I'm now running about 105 . I don't want to be on meds, especially given these reactions. Is the thirst, cramping and nausea normal?

    PEOPLE'S PHARMACY RESPONSE: Nausea is very common (25% or so of patients in the clinical trials). Cramping is also fairly common; dehydration isn't.
    Keep in mind that although metformin may be the best of the drugs available for type 2 diabetes, it does have a rare but very dangerous side effect called lactic acidosis.

    I recently found out that I have Type 2 Diabetes. My Doctor prescribed Metforman, 500 MG Tablets to take twice a day. I also have Congestive Heart Failure and Chronic Obstructive Pulmonary Disease. I take the following medications as well; Sucralfate, Potassium, Prilosec, Carvedilol, Losartan Potassium, Folic Acid, Lorazepam, Zoloft, and Mirapex (for sleep apnea). The side effects I am experiencing are dry mouth, stomach upset, nausea, diarrhea, and bloating. I have been on Metformin. for two weeks

    I have been a diabetic since 1993 when I had breast cancer. I was on actos which is no good for your kidneys. My dr took me off of actos & put me on metformin. I am very dizzy. I was also on starlix from percristion solutions pharmacy it was a pink pill & never had any side effect. Then I changed insurance companies & now have express scripts & there starlix is different color and has a after taste.

    I am going back to my dr on aug 31, can't wait. I hate taking all these pills. I wonder what do they do to our bodies? I felt great with the other pharmacy, but not don't feel so good. My blood pressure was 190/90 but now much better, just lost 19lbs on weight watchers & plain to lose more. Any one have any answers for me thanks so much

    My Dr prescribed me metformin for PCOS and insulin resistance. I started taking them a few months ago, but stopped after a couple of weeks due to very bad diarrhea and stomach issues. As soon as I stopped the symptoms went away, but because the reason is was prescribed to me was to help conceive a baby, I started them again.

    This time I tried to slowly introduce my body to it, but its still not working, I need to be by a bathroom at all times and (sorry if TMI) but when I have diarrhea, it BURNS!! After reading all these comments, how do I know if my brand is the TEVA brand as well? because when I open my pill bottle, it does stink like dead rotting fish!!! I wonder if I take my prescription to a new pharmacy if perhaps that will help???

    My Metformin /glucophage experience, summarized.

    2002: Diagnosed PCOS, started Metformin /glucophage

    2004: Began having occasional but acute and severe gastrointestinal symptoms.

    2005: Realized gastro symptoms occurred after consuming certain foods. Had IGg blood test, discovered 25+ food sensitivities. Eliminated four worst foods from regular diet, began long-term loss of 60 lbs.

    2005--2012: Continued on metformin, saw endocrinologist 2--4 times per year for regular checkups. Continued losing weight due to food-intolerance restrictions and reactions, continued having severe /acute gastro reactions. Saw two different gastroenterologists, eventually diagnosed fructose-intolerant with slow gastric emptying in 2011, after three months of near-constant illness. Consulted dietician, began restrictive diet modifications.

    April, 2012: Reminded endocrinologist, at regular checkup, of gastro issues. He suggested short metformin holiday to see if gastro problems related to metformin. Within two weeks, I had gone from frequent diarrhea to occasional constipation and was eating foods that had been eliminated from diet in 2005. Have gained 15 lbs. since but am working to avoid gaining more.

    Aug., 2012: Saw endocrinologist for one-year checkup at my request, mainly to report result of discontinuing metformin. Endocrinologist aware of gastric issues when starting metformin but not aware of issues related to long-term use.

    Hope this anecdotal evidence will help someone else. Regular reader of "The People's Pharmacy" in San Antonio EXPRESS-NEWS.

    Hi All,

    I recently was switched from Solco brand metformin to the Teva USA brand of metformin (about three weeks ago). Since then, I have had my upper lip swell up to more than twice its size on three separate occasions since then. When it happened the first time (Sept 26), I went to an urgent care and they felt it was a reaction to something, such as a medication (which they thought may have been ramapril, which I have been taking for the past several years). They gave me a six day dose of a med to bring the swelling down. However, this swelling has happened twice since then. I will call my diabetic doctor Monday, but is it possible that it could be due to a switch from Solco metformin to Teva metformin ? I am not new to metformin in general though, have been taking for 9 years now.

    Also, as I read the posts above, I have also been having some of the self-destructive anxiety, to a degree, that other people have been describing.

    I have been on Metformin for three years. I had all the side effects of upset digestive system, they lasted a couple of weeks and would only return when dosage changed.

    It has taken me three years to lose weight and get my Blood Sugar (BS) down under 7.00 AIC. I got it there by diet the first three months but I am having trouble keeping it there. I started noticing that my Metformin was not lasting as long with the change at the pharmacy. I am not sure who produced the early meds.
    But I have been told I test to much (and Maybe so) but testing lets me know how I am doing as I change diet or activity. I know when something has changed and BS is going up.

    My BS was increasing at about the 6-8 hour of regular Metformin. This drug is to last 12 hours. I was wakening with a BS 200 -250. In the evening it would start climbing to 200, then I would take another dose and it would drop before bedtime to about a 100. I was also on Glipizide but it was causing the dog to wake me with low BS at 45-50. I stopped taking the Glipizide at night.

    Got a new script for Glipizide and it stopped working. Different Manufacturer.
    The Dr thought that I should try Januvia. Well my average BS started going up. I had a runny nose, started swelling in my feet and legs, and gained weight (16lbs in two months). I went off the Januvia.

    Then I started taking the Metformin 1000 Three times a day and I enjoyed control. I also had no side effects from the increase in dosage. I was holding down to a little under a 100. Great! Then the free clinic Dr. left and I got another one. She had a fit and made me go off the three times a day. I am back to going high at 6-8 hours a day.

    New development is I have torn tendons and tachycardia. I cannot walk from one end of the house to the other without my heart racing. I have a torn tendon in my shoulder which I believe is cause by one of my drugs but I do not know which. The New Dr. wants me to start beta blockers for the tachycardia, I am reluctant. She has referred me to a heart specialist, but I do not know when I will be called. Everything I see tonight makes me think it is the Metformin. I don't want to just keep taking drugs that treat symptoms. I want to know what is causing this. Is it the diabetes or the drugs?

    I think I will ask for a new script for none generic Metformin. And see what happens. Are any of these drugs made in America? or Canada? or somewhere safe?

    Got a new job and I will have full coverage under Health Insurance in January. I can go back to my old Dr. who is great.

    I have been taking GLYB/MET 5/500MG twice a day...with blood sugar readings normally in at 100. The Pharmacy switched to Teva Pharmaceuticals and now my Blood Sugar is in 300s.

    I believe I now received counterfeit drugs and I am going to 5MG GLYB and 500MG MET individually...no longer the combo drug and I also switched Pharamcies and will know something in about 7 days...I am shocked to see others having problems with this drug and with Teva Pharmaceuticals...now my fears may be realized...James

    Diagnosed with type 2 about 5 years ago. Doc put me on metformin right away. About 3 to 3&1/2 years ago I started getting stomach cramps. Saw several doctors and gastro docs. Some said it was GERD, some said it was ulcers, blah blah. None checked me for intolerances. Pain came and went (mostly present) over the next 3 years. It wasn't until I found several web pages about connecting long term metformin use to lactose intolerance. Apparently, I'm not alone in this gastric pain. I don't know if any study has been done, but I am now lactose intolerant.

    Stopped metformin for 2 weeks and started a lactase enzyme supplement which has abated the pain in around 20 minutes. My BS is now all over the place. Insulin injections are helping to control those. I suspect that when I start metformin up again, my BS will settle down and the lactose problem will also be under control too.

    I take Zoloft and Trileptal, and when starting Met 750 ER it seems to reduce their effectiveness. Depression is back, but when I don't take it for a few days, it gets better. Anyone else?

    I was prescribed Metformin for PCOS this past February. The Metformin I received was manufactured by Sun Pharmaceuticals. The medicine smelled strongly of urine. Was advised by pharmacist at CVS to not take it. Had script refilled at CVS, got med from another manufacturer with no smell. Any other people have similar experience?

    Same exact issues with the addition of muscle weakness. I stopped taking the met and realized that the food allergies would not go away. Now I can't eat some of my favorite foods! "They" may not be aware of it, but it's probably never been studied.

    I had a similar problem. I was on the metformin made by TEVA and then I got my prescription refilled and they gave me another brand. I began having all sorts of weird stomach pains and the pills were not dissolving in my digestive track like they were supposed to. I switched back to the metformin made by TEVA and the symptoms went away. I found out that each manufacturer of a generic drug can put a variety of fillers into their pills. These fillers are what most people react to when they get delayed symptoms.

    Can't believe there isn't something better than metformin. What a joke. Tried it on and since last spring with an A1C of 8.7. Couldn't manage to stick with it everyday - too stomach upsetting. A1C at 8.3 with BS at 168 after 7 months. Dr. wanted me to go from 500 mg to 1000 mg. Both way too much stomach upset/diarrhea/nausea/can't eat diet foods like salads or veggies - only Glucerna. What a joke.

    Last night was severe stomach dehydration and burning. This is ridiculous. Regular family Dr. gave up on me and my allergies and side effects and referred me to an endocrinologist of whom there are none in our area for 30 miles, so seeing one means more days off work. I am not a lab specimen and I refuse to live like one. No one can tell me the perfect food(s) that balance all this out, nor the meds that work,have no side effects and don't increase weight. At already 290 lbs gaining weight to control BS is not an option.

    Exercise is of minimal help due to knee replacements and exhaustion caused by the metformin. I really think a lot of the food issues are the gmo'd foods today -- you can't fool mother nature.

    I have been on Metformin for about a week. Today I am feeling very depressed and do not want to live. My stomach pains have been the worst ever and I am having gastrointestinal problems. also having severe heartburn. big burps and SO much gas..... its disgusting.

    It says I need to take the Metformin around food time - except all I had was a cheese sandwich and threw it up. Forced myself to have lunch now. If you have no food in your stomach you should not take the Metformin - catch 22!
    So tired all the time and yet cannot sleep.

    I've taken Metformin, so far, with as many different manufactures as the years I've been on it. Started in 2008. I have a serious problem with diarrhea. I've been prescribed different dosages, and the only amount that brought the A1c down was 2000 per day.

    Now I have been just diagnosed with an ulcer of some type and with hiatal hernia. I've been searching for a connection between Metformin and these two conditions and I think I found it today on this page. Thank you. Going to call the doc tomorrow and see if I can get a prescription for the Glucaphage original. Non-Generic. My Safeway pharmacy keeps changing brands on all my meds, not just Metformin. I've noticed a marked decrease in the quality of the way a drug works. Safeway tells me they can't do anything about it! They don't have control over it.

    Since the beginning I've also experienced extreme diarrhea, incapacitated for days on end. Cannot plan my day. Cannot take my meds until after I do my errands. Cannot go out to dinner with anyone for fear of having digestive episode. I have a lot of smelly gas and bloating and painful stomach aches. Socializing with friends is out of my life these days. I've always been told by the doctors, when I complain about it, that most people don't have those side effects. Now I know that isn't true.

    I have been experiencing lots of abdominal pain around the mid section and back pain. I am very tired! It seems as though it sometimes takes a lot of effort to move my legs -- like they were stuck or something. Bad tasting mouth and gum infection. After reading all your posts I see that is the metformin which I have been on for about a year now. I won't be taking this anymore! That's what put me into emergency with appendicitis symptoms. Turned out to be diverticulitis. I will go back to 3 drops of atomidine in the morning and to drinking my bay leaf tea at 4:00 in the afternoon. I had plenty of energy when I did that, no pain, and decent blood sugar levels. My high blood sugar seems to occur in the mornings.

    Just prescribed 2000metformin twice a day head aches running to rest room over heated passed out then came back around. sick to stomach and cramping. ─░ think too much of an increase too soon. calling doc today

    From now on I will check the generic pill and if it's made by the TEVA, I will never use the drug. I've been on Metformin approximately 4 years and it was always under control prior to switching to TEVA pill.

    These pills (Preliminary without actual lab test) has nothing to do with Mertformin and everyone should be very careful taking it. It has a fishy odor and initially I was on the 500mg and my A1C went through the roof at my first check around 3 months of usage, later my doctor bumped my dosage to 1000mg and my daily blood glucose check showed there was no improvement after 2 months of 1000mg.

    I've started using "Major" brand and currently it's doing fine. So Please be careful 500mg has a label 93 and 48 in the back, 1000mg has 93 and 72-14 in the back.

    Hi Megan. I was getting really scared maybe I had something terribly wrong with me, but after reading some of the comments on Metformin 500mg. HER I realize it very well could be the medication. I have been on Metfomin for several months now and I am having all kinds of trouble. I have had a bad case of diarrhea for 3 full weeks. I have lost a lot of weight because everything I eat goes straight thru me. Also, I am having some female problems. My vagina is very dry, itches, burns and even hurts. I go back to my doctor Tuesday and now I have some good information to talk with him about. You are not is the boat alone. I will keep you in my prayers. Good luck.

    Today was terrible with the stomach problems, gas and belching and burping. I was just taken off Meformin a week ago and wonder how long it will take for the stomach problems to go away. I do have small periods of time that I feel well with no symptoms. I have weak spells when I can hardly walk and do my chores. Could this be a lack of B-12 which has its own problems? I have read all these emails and they have been very helpful, like misery loves company!! Today I was convinced I had stomach cancer, an ulcer, etc, but found others have the same problem and it is the metformin.

    I was taken off Actos and started metformin several months ago, nothing happened at first , but I began to have strange symptoms like extremely high blood pressure a few hours after taking the 500 mg pill at supper. That stopped as soon as I was off the pill, but the stomach upset remains. I had been noticing that I felt very depressed at times and I am usually a very happy person, but I cry very easily now. I just pray that these symptoms will not last much longer. Wish I had been warned before I started taking it.

    I have been on Metformin for about three weeks. My Dr prescribed me metformin for PCOS and insulin resistance & I started with 500 mg & planning to end with 500g X 3 per day. I am also experiencing with stomach upset, nausea, sometimes diarrhea. Anyone have any idea about which is the best diet with metformin? Means I want to know if we are eating fruits, (apple, grapes, orange) that will give a negative effect for metformin?
    Thanks in advance!

    These side effects are temporary I've been taking Metformin for about 4 years now. Initially, it was horrible I had the same issues. The best option is to use the Extended tablets so that it releases small amount into your bloodstream. I take mine at night with the meal. Something solid in your stomach does help initially again it goes away after a while but make sure to keep an eye on your Lactic Acid in your blood. Good Luck and hang in there.

    Hello, I know it's been years since you posted this so I don't know if you're still having problems with acid reflux or not. My husband has a hiatal hernia and severe acid reflux. He was on omeprazole, prilosec, etc. for years and years. I have now learned that it is very bad for your body to stay permanently on that kind of medicine. You should only take it for two weeks. They rarely bother to inform you of that fact though. It just makes the problem worse when you overuse it.

    Finally, we did some research and decided to try papaya enzyme supplements. They work very well. Just as well as the omeprazole at least. Didn't stop the problem but they do help when he's have an episode of it. Also, another trick is to eat an apple, especially before bed. Any kind of apple. It does absolute wonders. Probably works better than anything else. Also, black licorice is helpful and peppermint hard candy is an old time standby for acid. Eating the apples and the papaya supplements have been the most helpful. They taste good too. Good luck to you. I hope you're doing better with it now.

    My husband has just started taking Metformin ER, he was taking Metformin for about 3 months but he had constant diarrhea so the doctor put him on the Metformin ER, that has helped with the diarrhea but now he is having muscle aches and pains. Does anyone know if the new medication is causing the muscle aches and pains or has anyone experienced this with this medication?

    I had taken Metformin 500 bid for several years. When I had my prescription refilled at Walgreens, I noticed that I felt kind of strange. I was light headed and my heart beat felt funny. I took my pulse and it was 40. I called the pharmacy and asked if they had changed anything about my prescription and they said they had changed the place they got the drugs from because of the cost.

    I have went off and back on with the same results. I am having a terrible time with my Dr. because he thinks I'm crazy and this would not cause this problem. I was on AAvapro for five years I was having PVC's so bad I was scared stiff. I kept telling my Dr. and he just disregarded my words. I finally told him you either take me off this stuff or I'm taking myself off. He put me on a event monitor to get my heart evulations and it was awful. He took me off and within 48 hours they were gone after having felt this way for all those years. I had a heart stent in January, and was on Metprolol 25mg and had terrible problems with that as well. I am so disheartened with my Drs. It really scares me.

    I just started the meds last week...so far I have had diarrhea twice. As far as muscle aches the info that comes with the meds states that that is a serious side effect and can cause death. I would contact your dr. Immediately .

    Following up my post of September 10, 2012.

    At one year off Metformin:

    --Weight gain stabilized at 30 lbs., still 30 lbs. under highest lifetime weight. That means I'm still better off than I was in 2004--2005, when my endocrinologist considered me pre-diabetic.
    "The beneficial health effects of weight loss: A 10- to 20-pound weight loss often improves blood pressure, blood cholesterol, and triglyceride levels. 24-27 Weight loss is also an effective therapy for reducing the risk of diabetes."
    http://www.cdc.gov/nutrition/downloads/r2p_life_change.pdf

    --I'm able to eat almost anything I like without gastric distress; carbonated drinks seem to be the exception.

    --My endocrinologist says his diagnosis is "rare digestive reaction to Metormin" and not (thank goodness) lactic acidosis. (Based on the anectdotal evidence above, I think it's more common than the medical pros realize.)

    --My lab numbers remain very good; just had checkup with endocrinologist.

    There's a medication-disposal event in my area tomorrow. I will VERY happily get up early to dispose of the leftover Metformin pills!

    Hope you are doing better now than you were in March. When I discontinued Metformin a year ago, after eight years of increasing indigestion, I was back to pre-2004 "normal" within a month. Hope your results were the same.

    I'm having the same problem. Certain foods became off limits and now that I'm not taking it anymore, I still can't have the foods! tops on the list is eggs, but I can also have trouble with salads (raw veggies) and even fried foods.

    Did they change your medication? I tried the Met ER and then the regular taking 1/2 250 mg and it keeps interacting with my Armour Thyroid. Went off of the Met and my body started to calm down. I m on Day 5 of being off. Called the diabetes doc and she said that was okay will see her soon. I am still taking Actos bs numbers are inching up. Trying to exercise more. Got scared blood pressure went up. Now I'm on the couch. Also had tried Januvia and Onglyza made me depressed after a month. I was hoping metformin would be the answer. Pharmacist at Cleveland Clinic recommended Prandin or Starlix. Anybody have luck with either of those? I am so discouraged. KBG

    That's what brought me here. Now it's confirmed. I'd rather have a short sane happy life than a longer one riddled with serious mood swings, leg cramps and diarrhea. Thank you for sharing, my experience with met has been like yours.

    I have been on Metformin for about 3 1/2 years now. I am having all kinds of stomach pains, food intolerances, and allergies that I did not before ask well. I have an appt. with a GI doc in a couple weeks, but now I'm thinking it could be the Metformin. I am on it for PCOS.

    See my posts of Sept. 2012 and May 2013.

    CORRECTION to my post of Sept. 10, 2012

    GASTROENTEROLOGIST was aware of gastric issues when starting metformin but not aware of issues related to long-term use. Asked endocrinologist to send info on long-term effects to gastroenterologist.

    It seems to me, this helpful website is a magnet for complaints. Not too many people saying metaformin works great. The only problem with this, is the demographics are way out of balanced.
    A peruser of these pages may come under the assumption that there are too many negative aspects to this drug, when in fact, they're visiting a website containing mostly peoples negative reports of side effects.

    These side effects really do exist, and this is the place to air out these experiences. Imagine what it would be like, if no site like this existed? YIKES! Yet this pool of negative side effects, may cause fear or doubt to those who happen to read about this drug, not realizing these pages of reports, make up a small number of millions who have positive experiences, and these far, outweigh most accounts found here! Kind of like a vortex of fear.

    At times this presents fodder for some sneaky ones, to recruit adherents to alternative non-medical therapies to spend their money on. Yes, this drug has side effects, as reported here. But the side effects of diabetes are many and serious. Every hour, worldwide, people by the thousands are suffering the grave results from this disease. Amputations, Blindness, Organ failure, etc. Not too many people are experiencing those side effects from Metformin.

    The gracious hosts of this site, do all they can to alleviate some of the "wilder" side effect questions expressed, while allowing the public freedom to use this site. Thus, please remember even though these reports on this webpage are true and need to be reported and compared, you are not reading about the invisible, vast majority of people with nothing to complain about, concerning this drug!

    -Just an observance and opinion that is relegated to the bottom of a huge pile of comments.

    People's Pharmacy response: Thank you for the observation that most people who are happy with their medications do not go online to praise them. In our opinion, metformin is one of the best prescription drugs for type 2 diabetes.

    To the extent that people are able to control their blood sugar with diet, supplements, and exercise, we cheer for them. But not everyone is able to achieve complete control in that manner. For them, a medication like metformin can be extremely useful.

    while it's all well and good that this medication works well for some. It is being prescribed for multiple conditions, and sometimes by well meaning docs who really don't know what the real effects of this medication are. They are unable to answer questions regarding side effects that have been reported, but not documented by big pharma.

    I've lived with the after effects of this medication for years after stopping it (have never been diabetic or even remotely insulin resistant). The allergies I've developed, the muscle fatigue and constant upset stomach coupled with ibs-like symptoms ARE very real and are important things for people to know before blindly taking the medication. If I had known this could happen I never would have taken the meds in the first place!

    I also have family members who have taken it for diabetes and they had very similar experiences, but once stopping the meds, their symptoms stopped, while mine have continued for years. if in 30 or 40 years I develop a problem with my blood sugars, it will be my motivation to eat right and exercise to control them because I OUTRIGHT REFUSE to ever take this drug again!

    I have been on metformin for about 4 years but suddenly i started developing joint pains especially at the phalanges. My doctor asked me to stop but without an alternative. My bg has not been under proper control since then.

    Question: Is this a known side effect of metformin?
    Is there an alternative that can effectively replace metformin?

    People's Pharmacy response: Not a common side effect of metformin.

    I have just started metformin again for the second time and both times I realized that I have developed a severe yeast infection. I do not know if this could be a side effect or allergy, if anyone knows, please let me know thanks.

    I was wondering the exact same thing. I have, rather incredibly, all of the factors you mentioned except I have never been diagnosed with PCOS--tho suddenly I definitely feel I should look into it. I have a massive predisposition towards candida: being prescribed an antibiotic usually results in a vast number of tears and having a lot of trust with a new doctor. I have been on and off with taking the metformin as the gastric discomfort and time spent in the rest room served to make me not only miserable but quite useless as well. I recently started back up and noticed a sudden onset of migraines (though they had gone down for a very long time now--happening more like once a month instead of 2-3 each week) as well as several major thrush symptoms I haven't seen the severity of in years! I realize this is 2 years later :/ maybe you have some answers to share with me?

    I stopped taking it. It took about 3 weeks for the yeast infection to go away completely, but I am not taking it anymore. I will find something else if I have to. I would suggest if you are still having problems, talk to your doctor and see if you can be put on something else..

    taking 1000mg 2x a day for a month. Urine is dark yellow all day long and smells terrible. BS is down and stable but other side effects are mild diarrhea and numb cold feeling in legs

    Ate pizza for lunch and BS spiked to almost 190 after eating

    Please do not blame metformin. I agree side effects are possible, however blame it on the disease i.e. diabetes.
    Without diabetes there would be no need for metformin. (Possible side effects as with every medication).

    Hi!
    I have been taking Metformin for more then 10 years for PCOS, can Metformin cause bloating? and water retention?

    My stomach is always big and feels hard, I cannot understand, I am eating more fiber,
    thank you

    I'm taking metformin for PCOS. I've been taking it for around 3 weeks, as well as provera. I take the provera for the 20-29th of each month (in other words, as of writing this I've been off it for a week so I know it's no longer having an effect on my body). Ever since I started the metformin I am suffering from huge mood swings and horrible depression and anxiety. I have a history of depression and anxiety, but never like this. I am on edge, I have a horrible short fuse, all I want to do is cry... The list goes on.

    I know it is the metformin causing this, however my question is will this go away? If I only have to feel like this for a short time, I think I can handle it, but if it might not go away I can't do it. It is helping my PCOS, and I want to keep taking it for that reason, but not when every day I'm thinking about different ways to die and flipping out on my family over absolutely nothing.

    As a side note, I also suffered from some stomach upset and vivid dreams/nightmares for about a week after starting the metformin, but they appear to have all gone away now. Just this horrible depression and anxiety are still bothering me.

    KH,
    *****Please call your doctor RIGHT NOW.*****
    Suicidal thoughts should be taken VERY seriously by you and your health-care providers. Also tell your family what's going on, so they can better help you. Don't fear psychological counseling; seeing a therapist was one of the best decisions of my life.

    Laura,
    I think your physician is the best resource regarding the water retention and bloating. Since getting off Metf., I've noticed that I easily react to high amounts of sodium (salt), BUT that can be a symptom of other issues.

    Read labels on food, beverages, and OTC medicines, so you'll be aware of sneaky hidden sodium. I react to the sodium in Coca-Cola and in docusate-sodium stool softeners.

    Blessings to both of you!

    Well, after reading this and doing physical therapy for weeks for knee and joint pain which is not getting better. Actually, now add shoulder pain and tired all the time. Schedule a new sleep study thinking that was the problem. Thinking all the stomach, digestive problems were gallstones issues.

    I done with metformin. Big Pharma wants you to believe these are isolated cases when in fact they are not. Also, my blood pressure was high end of normal now its cross the line and the doctor wants to add lisinopril. Enough, bs from big pharma, "there is a one to one correlation between Metformin causing high blood pressure, joint pain, depression, mood swings, anxiety, swollen feet and legs and heart racing. Just to name a few. The metformin and lisinopril are such wonderful drugs they are now handing them out to the public for free. No thanks! I am tired of being test subjects for Big Pharma.

    My 93 year old mother has been on Metformin 500mg bid for some time plus takes Glybizide. She recently started having lightheadedness and stomach pains. Should she maybe decrease the Metformin to one a day because she also has no appetite?

    I have been taking metformin 500mg 2 times a day every since late last year when I found out I was a diabetic. It as been a rocky road while being on this medicine. I have lost weight but I wish I didn't have to take this medicine. I have experienced drowsiness, heart palpitations, stomach pains and weakness. I know we are supposed to lose weight but I have to eat a certain amount of food so that the medicine won't make me sick. Today I ate breakfast and took my first dose, minutes later I started feeling woozy and lightheaded. I was having stomach pains on both at sides like someone had pliers squeezing and twisting them on my stomach. I thought I ate enough food so I'm I having this problem? I'm afraid to take my next dose of metformin. Please help asap?!!!!!

    I am a women of 68 years young. Been taking Met for 10 months.I was pre diabetic but Dr. put me on it anyway. I was swollen in the legs and ankles. Weight loss was 20 lbs. and then a stand still. No energy and and all I wanted to do was Sleep and be left alone. This is my problem and reason I quit the Metformin and will do this on my own.

    After going to the Dr. 2 weeks ago for blood work, (all results were good) I woke up one morning having a period. Called the pharmacist and he called it Renewed ovulation from Metformin. I feared cancer but was reassured that if it were, it would have shown up in my blood work. And if it were Cyst, I would have had pain. Anyone else that can tell me about this ? By the way I check my blood 3 to 4 times daily and I stay in the low 100's range.

    I am 66....been on Metformin ER for over 1 year.....having terrible cramping and loose watery stools for over 2 weeks now....my numbers are in good range...in fact....I was told I was pre-diabetic and numbers were only 6.8-7.0.......now I am a little below that and they say I am managing it fine now.

    However...since on Metformin ER....nothing but problems.....gastro, tiredness (which they tested my thyroid and I am on 150mcg dosage)...and now these terrible stomach pains and diarrhea....what to do...I want to quit the meds......what to do....anyone!?

    I would say everyone on med should stop their meds and adjust diet and exercise. I get the same results with or without med, but everyone is different.

    Absolutely DID NOT work for me. 500mg dose 1x per day, taken at lunch, completely wiped me out. So exhausted that I could not get through my day at all. I work two jobs, so this was a complete disaster. My arms and legs felt weak, shakey, like rubber; without any strength at all. My mind would not think of things, and tasks like making a grocery list took me much longer because the thoughts wouldn't work. I felt drugged and drunk. Blood sugars always tested okay. All I wanted to do is sleep.

    It DID bring my blood sugars right where they were supposed to be, but at what price?? I couldn't keep taking it. Why does a medicine that works so well on my sugars have to make me feel so awful? It isn't fair.

    Does anyone have urine leakage with metformin?

    On 2000 metformin a day at night after dinner.
    I have been on this dose for 3 weeks and the last 4 days have been sitting in rest room with servere gastro. Is this common? please help.

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