Overview

Estrogen-like drugs are being used ever more widely to treat a number of
conditions associated with menopause and later life in women.

In
addition to menopausal symptoms such as hot flashes or vaginal dryness, Estrace
may also be prescribed to prevent osteoporosis and reduce the risk of heart
disease.

Estrogen can also be helpful in various conditions where a
woman does not produce enough natural estrogen.

Certain cancers in men
and women may benefit from estrogen therapy.

Estradiol is also the active
ingredient in Climara, Estraderm, and Vivelle skin patches, which are prescribed
primarily to menopausal women.

Estrace vaginal cream is used primarily
to counteract vaginal symptoms following menopause; estradiol is absorbed from
the vagina into the bloodstream.

Side Effects and Interactions

Estrace has several potential side effects,
including breakthrough menstrual bleeding, breast tenderness, bloating, nausea,
vomiting, stomach pain, headache, gallbladder problems, liver tumors,
depression, jaundice and high blood pressure.

Some women experience an
increase in blood sugar and may go on to develop diabetes.

The skin may
become more sensitive to sun, so it is wise to use sunscreen and wear protective
clothing (including a hat and sunglasses) if you will be outside.

Other
adverse reactions include changes in weight, fluid retention, alteration in sex
drive, and change in the curvature of the cornea. This may make contact lenses
inappropriate. Report any symptoms or suspected side effects to the physician
promptly.

Your doctor should be notified immediately of any of the
following symptoms: pain in the calf or groin, sudden shortness of breath or
sharp chest pain, sudden severe headache, blurred vision or speech, weakness or
numbness in an arm or leg, yellow skin or eyes or severe abdominal pain.

Let your doctor know if you suspect you may have become pregnant, if you
feel seriously depressed, if you notice lumps in your breast, or if vaginal
bleeding is abnormal.

Estrace may interfere with tests of prothrombin
time and certain thyroid tests.

Estradiol may interact with prescription
drugs such as theophylline and beta blocker blood pressure pills.

The
activity of the anticoagulant Coumadin and that of certain antidepressants may
be altered.

Alcohol can raise circulating levels of estradiol
significantly. The equivalent of half a glass of wine doubled estradiol blood
levels, while three glasses’ worth more than tripled the effective dose of
Estrace. Skin patches are also affected, though less dramatically. Blood levels
of estradiol rose 40 percent after alcohol consumption.

Estradiol levels
also get a boost from grapefruit. Regular consumption of grapefruit or juice has
a cumulative effect that increases estradiol exposure.

Until the
estrogenic activity of hops is further studied, taking this herb in combination
with medicines such as oral contraceptives or hormone replacement therapy is an
experiment best avoided.

In general, the herb chaste tree berry should
not be combined with menopausal hormone replacement therapies.

Saw
palmetto berries, which have both estrogenic and antiestrogenic activity, are
not recommended.

Check with your doctor and pharmacist before taking any
other medicine or herbs while taking Estrace.

Special Precautions

Pregnant women should not take Estrace, as it could have a negative effect on the fetus.

Women with a history of breast cancer or other malignant disease responsive to estrogen are generally advised to avoid this hormone.

Blood clotting disorders such as thrombophlebitis are also a reason to be wary of Estrace.

Prolonged use of postmenopausal estrogen has been controversial because of questions about cancer. Endometrial carcinoma or cancer of the uterine lining is more of a risk for women exposed to estrogen. This adverse reaction may be counteracted by simultaneous administration of progestins.

Vaginal bleeding could be an early warning sign of cancer and requires immediate medical attention.

Long-term use of postmenopausal estrogen protects against heart disease, but it increases the risk of breast cancer by approximately 40 percent, according to data from the Nurses’ Health Study.

Women with a strong family history of breast cancer will want to discuss this issue with their doctor and may want to delay use of Estrace until later in life when heart disease becomes a more urgent threat.

Taking the Medicine

The best dose and timing of Estrace tablets differ depending on the purpose for which they are
prescribed.

Postmenopausal women experiencing hot flashes or other symptoms generally take
one pill daily for three weeks, and no Estrace for the following week.

Doctors often
prescribe a progestin compound in addition for women who have not had a hysterectomy.

Make sure you understand the schedule of when to take Estrace and when to take the progestin.
Transdermal patches are applied to clean, dry, intact skin on the trunk of the body, but not to the breast.

The usual treatment regimen calls for a patch to be applied at the beginning of the week and left in place until another is applied to a different site halfway through the week.

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  1. Terry T.
    Reply

    Since there are more CONS than PROS with this Estradiol, I would like to know if there is something else I can use in place of this cream. Included in the side-effects is also dementia, NOT GOOD. I wonder if I really need this cream or can I substitute it for a natural/organic cream?
    Thanks. T.T.

  2. RKH
    Reply

    I use the Estrace vaginal cream to treat recurring bladder infections. I am 74 and have been off estrogen for several years (I don’t have a uterus and started taking Premerin when I was about 45 or 50 and quit taking it about about six years ago.) I started getting bladder infections soon after I quit the premerin.
    At first I got them every three months but recently, they started coming monthly. My doctor prescribed the Estrace cream, three times/week, to thicken the wall of the bladder and to help improve muscle control in that area and it seems to be working since I am going on two months without an infection.
    My question is this: I read that grapefruit should not be ingested when taking estrace and that it may also affect cozaar which I take for blood pressure. In one article I read from your site, grapefruit bioflavonoids may be the ingredient in grapefruit causing the problem. I don’t eat grapefruit anymore, or drink grapefruit juice, but I do take TWINLAB C-Plus Citrus Bioflavonoid Caps with Rutin, 2/day, to help prevent bruising and for general vascular health.
    I read on the bottle that these caps do contain concentrated grapefruit bioflavonoids as well as those from fresh lemons, oranges, limes and tangerines. Should I stop taking these caps? Will the bioflavonoids affect my meds the same way eating grapefruit will? I would appreciate any information I can get on this. Thank you.

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